11–20 of 52 posts
Type 2 diabetics on metformin live 15% longer than non-diabetics. This is remarkable considering how big a health disadvantage diabetes itself is.
Metformin seems to mimic fasting somehow, by interfering with mitochondrial function.
For more information I refer you to David Sinclair's numerous discussions on this topic. He takes 1 gram of metformin per day with his evening meal.
This is not medical advice.
Have children. That’s the easy natural way to prolong the life of your genes, the unit evolution and natural selection works with. Kids and grandkids also keep you on your toes and help you feel younger. Technology to extend the life of an individual so far only extends the more grim elderly part, which unfairly imposes costs on the young with no offsetting benefit. Wanting to live forever or get revived somehow in t…
Longevity research has never been about extending the sick part of life. It’s about avoiding the sick part of life for as long as possible.
Get rich. The average or even moderately wealthy probably won't have any chance at access to these technologies if they come to fruition. You'll also need a lot of extra wealth to keep yourself from an extra-long dotage in poverty. For myself, I plan to die before I hit 60. I'm not going to spend decades in pain and misery for no reason, life already sucks without my body falling apart. Kevorkian diet all the way!
Get rich. The average or even moderately wealthy probably won't have any chance at access to these technologies if they come to fruition. You'll also need a lot of extra wealth to keep yourself from an extra-long dotage in poverty. For myself, I plan to die before I hit 60. I'm not going to spend decades in pain and misery for no reason, life already sucks without my body falling apart. Kevorkian diet all the way!
People say “if it ever comes it will only be for the super rich” because they are afraid to let themselves experience the emotion of wanting something that might not be possible.
Human trials are expensive and obviously take multiple decades, so you’ll be dead before to see that data.
The compounds so far are:
rapamycin, acarbose, 17-alpha-estradiol, canagliflozin, asthaxanthin, meclizine
Get rich. The average or even moderately wealthy probably won't have any chance at access to these technologies if they come to fruition. You'll also need a lot of extra wealth to keep yourself from an extra-long dotage in poverty. For myself, I plan to die before I hit 60. I'm not going to spend decades in pain and misery for no reason, life already sucks without my body falling apart. Kevorkian diet all the way!
What happens if you are still alive at the age of 60?
Get rich. The average or even moderately wealthy probably won't have any chance at access to these technologies if they come to fruition. You'll also need a lot of extra wealth to keep yourself from an extra-long dotage in poverty. For myself, I plan to die before I hit 60. I'm not going to spend decades in pain and misery for no reason, life already sucks without my body falling apart. Kevorkian diet all the way!
Among the most promising anti-aging drugs is metformin. Type 2 diabetics on metformin live 15% longer than non-diabetics. This is remarkable considering how big a health disadvantage diabetes itself is. Metformin seems to mimic fasting somehow, by interfering with mitochondrial function. For more information I refer you to David Sinclair's numerous discussions on this topic. He takes 1 gram of metformin per day with…
Get rich. The average or even moderately wealthy probably won't have any chance at access to these technologies if they come to fruition. You'll also need a lot of extra wealth to keep yourself from an extra-long dotage in poverty. For myself, I plan to die before I hit 60. I'm not going to spend decades in pain and misery for no reason, life already sucks without my body falling apart. Kevorkian diet all the way!
What I mean by this is that current-you and 60-year-old you will be so different from each other that they could be different individuals entirely. You will likely still share some atoms by mere chance, but most of your 60yo body will be made of different atoms. 60yo’s mind will have many memories and experiences in common with you, but also a bunch of different ones. And their circumstances will also be different.
Think about 10-year-old you. Did they have plans for current-you? Have you fulfilled those plans?
Among the most promising anti-aging drugs is metformin. Type 2 diabetics on metformin live 15% longer than non-diabetics. This is remarkable considering how big a health disadvantage diabetes itself is. Metformin seems to mimic fasting somehow, by interfering with mitochondrial function. For more information I refer you to David Sinclair's numerous discussions on this topic. He takes 1 gram of metformin per day with…
IIRC metformin may also cause fertility problem in men, after prolonged use (which is required to get slow-aging effect).
You will lose your appetite and it will be hard to want to eat. You will tend to lose weight and eat just enough.
It can make you nauseous and you will probably find the bitter taste and fishy (amine) smell of the pills to be repulsive.
It is not an easy drug to take, and like you said, it may also affect male fertility.
But it is well-studied and safe, and offers various benefits.