I was prescribed benzos because of sleeping issues, but I was also taking phenibut at the same time. After about 3 weeks of using large doses of the benzos every night, I stopped taking them, but a year later I still feel pangs of withdrawal sometimes when I get stressed. It took me another 4 months to get off the phenibut and a month or so after that before my sleep returned to normal. There were months where I mayb…
Long-term benzodiazepine use causes synapse loss and cognitive deficits in mice
341–350 of 400 posts
Re: Long-term benzodiazepine use causes synapse loss and cognitive deficits in mice
#342Re: Long-term benzodiazepine use causes synapse loss and cognitive deficits in mice
#343I was prescribed benzos because of sleeping issues, but I was also taking phenibut at the same time. After about 3 weeks of using large doses of the benzos every night, I stopped taking them, but a year later I still feel pangs of withdrawal sometimes when I get stressed. It took me another 4 months to get off the phenibut and a month or so after that before my sleep returned to normal. There were months where I mayb…
Is this literally what the doctor prescribed?
Re: Long-term benzodiazepine use causes synapse loss and cognitive deficits in mice
#344The world of medecine is degenerate. Sustainable, non addictive and non neurotoxic anxiolytics exists: the #1 being opipramol the sigmaergic. emoxypine (which btw cure hangover) and guanfacine are worth mentioning. Maybe beta blockers to some extent. NMDA antagonists such as memantine have side effects but are not neurotoxic to my knowledge and there are milder ones such as mg-lthreonate. afobazole is interesting but…
Re: Long-term benzodiazepine use causes synapse loss and cognitive deficits in mice
#345Re: Long-term benzodiazepine use causes synapse loss and cognitive deficits in mice
#346I was prescribed benzos because of sleeping issues, but I was also taking phenibut at the same time. After about 3 weeks of using large doses of the benzos every night, I stopped taking them, but a year later I still feel pangs of withdrawal sometimes when I get stressed. It took me another 4 months to get off the phenibut and a month or so after that before my sleep returned to normal. There were months where I mayb…
Re: Long-term benzodiazepine use causes synapse loss and cognitive deficits in mice
#347Earlier quoted context omitted.
> if it ever became bad enough that I did feel like I was losing control (upping the dose, taking during the day, etc), then I would treat that as a sign that it was time to start thinking more seriously about exiting the situation that is the main root cause. I would argue that taking a drug to cover over something like anxiety is exactly the sort of circumstance that usually ends up with people being addicted/depen…
I wish people would give less medical advice over the Internet, even when it's well meaning. You're sort of right but the reality is that you can't just go find the root cause and "solve" it most of the time. How do you know a person you're advising over the Internet hasn't already tried? How do you know they weren't abused as a child, or a veteran suffering from PTSD, or a rape victim or any other number of things w…
Re: Long-term benzodiazepine use causes synapse loss and cognitive deficits in mice
#348Earlier quoted context omitted.
Because you have no self control a substance should be banned. Cool world that would be to live in.
These drugs chemically change the brain, so your brain might fall into a state where you lose control. Drugs often get pulled decades after being approved, usually because the safety studies were not expansive enough to give a complete picture of the danger. For example: Varenicline.
Re: Long-term benzodiazepine use causes synapse loss and cognitive deficits in mice
#349Earlier quoted context omitted.
Same here. Occasional clonazepam use for panic attacks which are secondary to post-traumatic stress disorder. Never even the tiniest sign of dependence. Sometimes I go months between uses. I am also a chronic pain patient and I worry that benzos are going to get the opioid treatment. There was a period in the mid to late 2010s where patients who depended on opioids for any sort of quality of life were taken off of th…
long term constant exposure to opioids will literally begin cause the pain they purport to solve. If you give a perfectly healthy person with no pain at all opioids for long enough they will be indistinguishable from a person who has an actual chronic pain issue. people should only ever take opioids VERY TEMPORARILY to get through surgeries or other such things. Opioids are not for long term pain management. Same thi…
Re: Long-term benzodiazepine use causes synapse loss and cognitive deficits in mice
#350Earlier quoted context omitted.
Of the common legal drugs, benzos are by far the most dangerous to quit. And you get addicted in like a week. Be very careful.
There was a tea bar in my neighborhood that would put kratom in one of the teas. It didn't make me feel particularly euphoric, but I did find myself craving it the next day. Shit is fucking weird and scary.