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Long-term benzodiazepine use causes synapse loss and cognitive deficits in mice

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341–350 of 400 posts

Re: Long-term benzodiazepine use causes synapse loss and cognitive deficits in mice

#341

I was prescribed benzos because of sleeping issues, but I was also taking phenibut at the same time. After about 3 weeks of using large doses of the benzos every night, I stopped taking them, but a year later I still feel pangs of withdrawal sometimes when I get stressed. It took me another 4 months to get off the phenibut and a month or so after that before my sleep returned to normal. There were months where I mayb…

I recommend trying clonidine . It was a life saver for me

Re: Long-term benzodiazepine use causes synapse loss and cognitive deficits in mice

#343

I was prescribed benzos because of sleeping issues, but I was also taking phenibut at the same time. After about 3 weeks of using large doses of the benzos every night, I stopped taking them, but a year later I still feel pangs of withdrawal sometimes when I get stressed. It took me another 4 months to get off the phenibut and a month or so after that before my sleep returned to normal. There were months where I mayb…

> 3 weeks of using large doses of the benzos every night

Is this literally what the doctor prescribed?

Re: Long-term benzodiazepine use causes synapse loss and cognitive deficits in mice

#344

The world of medecine is degenerate. Sustainable, non addictive and non neurotoxic anxiolytics exists: the #1 being opipramol the sigmaergic. emoxypine (which btw cure hangover) and guanfacine are worth mentioning. Maybe beta blockers to some extent. NMDA antagonists such as memantine have side effects but are not neurotoxic to my knowledge and there are milder ones such as mg-lthreonate. afobazole is interesting but…

Opipramol is a weird one. It's among the most prescribed anti-depressants in Germany (and other European countries), yet apparently non existent in the US.

Re: Long-term benzodiazepine use causes synapse loss and cognitive deficits in mice

#345

Earlier quoted context omitted.

is that a question? Benzos are not safe despite what many doctor believe. I'm in EU.

they're saying they wouldn't be so easily prescribed in the US

Actually the opposite. Pharma making people addicted: Opioid epidemic and all.

Re: Long-term benzodiazepine use causes synapse loss and cognitive deficits in mice

#346

I was prescribed benzos because of sleeping issues, but I was also taking phenibut at the same time. After about 3 weeks of using large doses of the benzos every night, I stopped taking them, but a year later I still feel pangs of withdrawal sometimes when I get stressed. It took me another 4 months to get off the phenibut and a month or so after that before my sleep returned to normal. There were months where I mayb…

Just use Marihuana and stop taking synthetic shit.

Re: Long-term benzodiazepine use causes synapse loss and cognitive deficits in mice

#347

Earlier quoted context omitted.

> if it ever became bad enough that I did feel like I was losing control (upping the dose, taking during the day, etc), then I would treat that as a sign that it was time to start thinking more seriously about exiting the situation that is the main root cause. I would argue that taking a drug to cover over something like anxiety is exactly the sort of circumstance that usually ends up with people being addicted/depen…

I wish people would give less medical advice over the Internet, even when it's well meaning. You're sort of right but the reality is that you can't just go find the root cause and "solve" it most of the time. How do you know a person you're advising over the Internet hasn't already tried? How do you know they weren't abused as a child, or a veteran suffering from PTSD, or a rape victim or any other number of things w…

In this case the parent said that they know what the root cause is, and hinted that they could solve it if it came to it. But they didn't think they needed to, because they thought that habitual cannabis use wouldn't cause them any issues. It seems reasonable to me to point out that such situations often cause problems, and that people don't usually realise until it's too late.

Re: Long-term benzodiazepine use causes synapse loss and cognitive deficits in mice

#348
post #152

Earlier quoted context omitted.

Because you have no self control a substance should be banned. Cool world that would be to live in.

These drugs chemically change the brain, so your brain might fall into a state where you lose control. Drugs often get pulled decades after being approved, usually because the safety studies were not expansive enough to give a complete picture of the danger. For example: Varenicline.

Just like all drugs, but the downsides of criminalization have been obvious for decades. I don't see a solution that isn't all drugs being cheap and legal.

Re: Long-term benzodiazepine use causes synapse loss and cognitive deficits in mice

#349
post #224

Earlier quoted context omitted.

Same here. Occasional clonazepam use for panic attacks which are secondary to post-traumatic stress disorder. Never even the tiniest sign of dependence. Sometimes I go months between uses. I am also a chronic pain patient and I worry that benzos are going to get the opioid treatment. There was a period in the mid to late 2010s where patients who depended on opioids for any sort of quality of life were taken off of th…

long term constant exposure to opioids will literally begin cause the pain they purport to solve. If you give a perfectly healthy person with no pain at all opioids for long enough they will be indistinguishable from a person who has an actual chronic pain issue. people should only ever take opioids VERY TEMPORARILY to get through surgeries or other such things. Opioids are not for long term pain management. Same thi…

[deleted]

Re: Long-term benzodiazepine use causes synapse loss and cognitive deficits in mice

#350
post #78

Earlier quoted context omitted.

Of the common legal drugs, benzos are by far the most dangerous to quit. And you get addicted in like a week. Be very careful.

There was a tea bar in my neighborhood that would put kratom in one of the teas. It didn't make me feel particularly euphoric, but I did find myself craving it the next day. Shit is fucking weird and scary.

It isn't a terribly difficult drug to quit but it is addictive. Some people use it to wean themselves off of opoids.
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