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Long-term benzodiazepine use causes synapse loss and cognitive deficits in mice
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Re: Long-term benzodiazepine use causes synapse loss and cognitive deficits in mice
#112I was prescribed benzos because of sleeping issues, but I was also taking phenibut at the same time. After about 3 weeks of using large doses of the benzos every night, I stopped taking them, but a year later I still feel pangs of withdrawal sometimes when I get stressed. It took me another 4 months to get off the phenibut and a month or so after that before my sleep returned to normal. There were months where I mayb…
It's much the same with chronic alcohol usage, and a very similar pathway. Both alcohol and benzodiazepines bind to GABA receptors, and through several difference mechanisms (desensitization, downregulation through gene expression, degradation), these receptors become less sensitive. GABA receptors are critical to sleep. After prolonged usage of alcohol, or benzos, sleep often becomes impossible without an ever-large…
Someone close to me has long been addicted to both alcohol and Ambien (sleeping pills).
I'd never considered that alcohol could trigger the need for Ambien. I'd presumed it was a lifestyle thing for someone who was used to being out all night.
Re: Long-term benzodiazepine use causes synapse loss and cognitive deficits in mice
#113Jordan Peterson had a horrible time with these drugs and resorted to extreme measures to get off them (eight days in an induced coma!) Even today he might still be on them - he is pretty cagey about his present pharma situation when asked about it on podcasts. https://nationalpost.com/health/jordan-peterson-benzodiazepi... Horrible drug.
It's also pretty obvious that he is cognitively impaired.
Re: Long-term benzodiazepine use causes synapse loss and cognitive deficits in mice
#114be interesting to study someone, or a mouse I guess with said damages and doses of ambien for repair (https://jamanetwork.com/journals/jamaneurology/article-abstr...)
Re: Long-term benzodiazepine use causes synapse loss and cognitive deficits in mice
#115Earlier quoted context omitted.
Can police help? Alternatively, (non-violent) retaliation? Seems like there's no downside for this person to be harassing you. Creating a downside might make her think twice next time.
Assuming GP is male, he probably doesn't want to do something that might be seen as being aggressive, harassing or upsetting to her, even if not violent. Threatening to involve the police is a common way women abuse men. You can of course involve the police yourself but they often won't listen. I had an ex try to create a situation where I would be framed for rape by creating fake social media accounts purporting to…
I had similar experiences and police are pretty much useless in that case, flat out said since you're physically stronger than the stalker there's no threat to your life. Oh well... Its a constant torture.
Re: Long-term benzodiazepine use causes synapse loss and cognitive deficits in mice
#116I was prescribed benzos because of sleeping issues, but I was also taking phenibut at the same time. After about 3 weeks of using large doses of the benzos every night, I stopped taking them, but a year later I still feel pangs of withdrawal sometimes when I get stressed. It took me another 4 months to get off the phenibut and a month or so after that before my sleep returned to normal. There were months where I mayb…
Of the common legal drugs, benzos are by far the most dangerous to quit. And you get addicted in like a week. Be very careful.
There was a tea bar in my neighborhood that would put kratom in one of the teas.
It didn't make me feel particularly euphoric, but I did find myself craving it the next day. Shit is fucking weird and scary.
Re: Long-term benzodiazepine use causes synapse loss and cognitive deficits in mice
#117Jordan Peterson had a horrible time with these drugs and resorted to extreme measures to get off them (eight days in an induced coma!) Even today he might still be on them - he is pretty cagey about his present pharma situation when asked about it on podcasts. https://nationalpost.com/health/jordan-peterson-benzodiazepi... Horrible drug.
Peterson is a verified idiot with nonexistent self-control. Not the slightest modicum of it.
Basing anything off of his antics is asinine. So weird to see people who put him on a pedestal on HN.
& benzos aren’t “horrible drugs”
People who don’t know how to manage themselves and their usage of them are horrible people though, especially when they try to cut down others who have no issues using them responsibly, which sometimes literally saves their entire lives.
Re: Long-term benzodiazepine use causes synapse loss and cognitive deficits in mice
#118I take a half tablet (10mg) of Xanax every once in awhile. (Maybe once a month on average).
It makes me feel so relaxed.
I knew it was too good to be true.
Re: Long-term benzodiazepine use causes synapse loss and cognitive deficits in mice
#119Re: Long-term benzodiazepine use causes synapse loss and cognitive deficits in mice
#120I was prescribed benzos because of sleeping issues, but I was also taking phenibut at the same time. After about 3 weeks of using large doses of the benzos every night, I stopped taking them, but a year later I still feel pangs of withdrawal sometimes when I get stressed. It took me another 4 months to get off the phenibut and a month or so after that before my sleep returned to normal. There were months where I mayb…
> I tell everyone to never take benzos for any reasons
You can't generalise your experience. Everybody is different and that's the doctor's job to assess whether the benefits outweigh the cost, considering the patient and their problems.
Personally, I've been taking benzos very occasionally for 20 years (never more than a few days at a time) and they helped me overcome difficult times. Never had the slightest addiction or side effects.
> Treat the cause, not the symptoms.
Easier said than done