Imagine if it turns out that 30 mls a month of blood loss for a few decades is the reason women live longer than man
I doubt it's so simple.
Transfusion of brain fluid from young mice improves memory in old mice
131–140 of 158 posts
Re: Transfusion of brain fluid from young mice improves memory in old mice
#132Next YC batch - Uber for youth fluids
Re: Transfusion of brain fluid from young mice improves memory in old mice
#133Earlier quoted context omitted.
But your blood is created by cells dividing and they cannot do so unlimited. Your DNA shortens and you run out of room for mistakes proteins make while translating it.
That doesn't seem right. Sperm and eggs are created by cell division too. In some sense you come from a line of cells that extends long before your birth. If cell division "wore out" after some number of divides you should be already worn out.
I've seen the claim that the correlation between increasing paternal age and the incidence of various congenital disorders has exactly this etiology.
I haven't been able to find a paper describing a mechanism, but my literature review tends to specialize in hymenopterological ethology, so I don't know that I would find such a paper even if it exists. The correlation is uncontroversial, though, and I suppose it might not be a surprise to see it demonstrated that the cause is in fact the accumulation of errors in the genome that's half-duplicated during spermatogenesis.
Re: Transfusion of brain fluid from young mice improves memory in old mice
#134Earlier quoted context omitted.
That doesn't seem right. Sperm and eggs are created by cell division too. In some sense you come from a line of cells that extends long before your birth. If cell division "wore out" after some number of divides you should be already worn out.
I've seen the claim that the correlation between increasing paternal age and the incidence of various congenital disorders has exactly this etiology. I haven't been able to find a paper describing a mechanism, but my literature review tends to specialize in hymenopterological ethology, so I don't know that I would find such a paper even if it exists. The correlation is uncontroversial, though, and I suppose it might…
Regardless - at some point "you" (or cells and genetic information that would become you) were an egg. At some point that egg was an egg, and that egg was an egg, and so on all the way up n generations to asexual and single celled organisms.
Re: Transfusion of brain fluid from young mice improves memory in old mice
#135These kinds of articles give me the creeps. As interesting as the science is, I imagine this also encourages a bunch of silicon valley millionaires and billionaires to essentially become vampires.
I don't know why it needs to start with Silicon Valley necessarily. Because we're a bunch of socially-awkward people? We just saw the Jeffrey Epstein thing unfold, and who-knows what well-connected old-money/old-power folks were serviced by him and Ghislaine Maxwell. If they could extend their life and get their pickings of young girls, you bet they'd do it.
This old-eating-the-young thing has been going on for time immemorial. It's encoded into our mythology, of Saturn eating his children so that they wouldn't usurp him. And it's not just our (i.e. Western) culture either.
Re: Transfusion of brain fluid from young mice improves memory in old mice
#136Earlier quoted context omitted.
I've seen the claim that the correlation between increasing paternal age and the incidence of various congenital disorders has exactly this etiology. I haven't been able to find a paper describing a mechanism, but my literature review tends to specialize in hymenopterological ethology, so I don't know that I would find such a paper even if it exists. The correlation is uncontroversial, though, and I suppose it might…
Regardless - at some point "you" (or cells and genetic information that would become you) were an egg. At some point that egg was an egg, and that egg was an egg, and so on all the way up n generations to asexual and single celled organisms.
Well yeah, but if complex self-replicating organisms aren't also very good at self-repairing, they don't self-replicate very long.
Individuals do get less good at it over time, though. The structures described earlier as "shortening" are called telomeres [1], and they do actually do that, as a result of DNA copying being a physically somewhat destructive process. They're purely structural rather than informatic, though, and everyone starts out with a fresh set.
Re: Transfusion of brain fluid from young mice improves memory in old mice
#137Earlier quoted context omitted.
This is one that I thought was compelling.[1] The trial ultimately failed but if you read the results the post-hoc analysis, it showed promise in mild and moderate subgroups of the ITT population. Most drugs today don't even target mild AD, but go after pre-symptomatic patients. There was also benefit across most measures, but just not of statistical significance. The trial had some major problems with appropriate co…
Thanks for checking. Alzheimer Management By Albumin Replacement (AMBAR) treatment has shown efficacy in slowing the progression of moderate & advanced stages disease [0, 1]. [0] https://doi.org/10.1080/14737175.2021.1960823 [1] https://doi.org/10.1002/alz.12137
Yeah, is totally absurd that given the health care and social cost of of Alzheimer's we're not taking Broad shotgun approach to investigating potential remedies.
There are a lot of treatments that's worth dumping several million dollars in even if they are low probability of having durable effects.
Re: Transfusion of brain fluid from young mice improves memory in old mice
#138Earlier quoted context omitted.
That doesn't seem right. Sperm and eggs are created by cell division too. In some sense you come from a line of cells that extends long before your birth. If cell division "wore out" after some number of divides you should be already worn out.
I've seen the claim that the correlation between increasing paternal age and the incidence of various congenital disorders has exactly this etiology. I haven't been able to find a paper describing a mechanism, but my literature review tends to specialize in hymenopterological ethology, so I don't know that I would find such a paper even if it exists. The correlation is uncontroversial, though, and I suppose it might…
Not just congenital disorders, but mental health disorders as well. It's been known for a while that paternal age is a risk factor for schizophrenia.
I had an internship at the New York State Psychiatric Institute (before I moved into software development). Paternal age was used as one factor in determining if people were at risk for psychotic breaks (schizophrenic prodromes) by one of the assessment tools they developed.
Re: Transfusion of brain fluid from young mice improves memory in old mice
#139Haven't similar things been observed with blood transfusions of young blood into the elderly, which was then found to actually be unnecessary - even just diluting the blood with something neutral and clean produced similar results. "The solution to pollution is dilution"
So drinking more water would be enough?
Well, that doesn't actually remove PFASs that linger forever in your blood, that the kidney can't filter.
But gently cutting your arm open and draining a pint into the sink will do the trick!
Re: Transfusion of brain fluid from young mice improves memory in old mice
#140Earlier quoted context omitted.
All the more reason to donate blood.
Donate blood and a man can bleed for a day. Donate marrow and a man can bleed for a lifetime.
A while ago I read about marrow donation. Turns out I had all kinds of misconceptions (thought it waa invasive and painful). I'll definitely try to donate when I get my health back in order.