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A drug that cures alcoholism may be the next anti-anxiety medication

tus.ac.jp

151–160 of 187 posts

Re: A drug that cures alcoholism may be the next anti-anxiety medication

#151

In my early twenties, I took Buspirone for anxiety and it got the job done. Its my understanding that they also prescribe this to Alcoholics. I'm curious what overlap that old drug has with this or if it is entirely novel. Ironically, in my late twenties i would have considered myself an alcoholic, long after i got off buspirone. I am three years sober now.

Busiprone is an atypical antianxiety medication. They can help some people with alcohol issues, it really depends on the person though. That's great it worked for you, it never did much more than make me sleepy

Re: A drug that cures alcoholism may be the next anti-anxiety medication

#152

I would prefer to see how we're progressing on the 'prevention of anxiety in the first place' front rather than another money-making band-aid for illusory effect. Not dismissing anxiety and a desire from those suffering to get out of it, but this wreaks of another case of solving difficult/complex problems with 'simple' solutions...

How do you remove anxiety from life? Maybe I'm misunderstanding, but to me life is inevitably gonna cause anxiety and if you removed all of it life would just be boring

Re: A drug that cures alcoholism may be the next anti-anxiety medication

#153

Earlier quoted context omitted.

"I urge people who have a problem with drinking and wish to quit, who for whatever reason do not feel that 12 step programs like Alcoholics Anonymous" I urge people to see an addiction specialist first. Do not see AA first. See a doctor asap. This disease is serious and has a high fatality rate. AA meetings are like a club after you have it under control (EG. don't attend drunk). Disulfiram: An old military drug. Thi…

"Rehab: Good short term, bad long term. Rehab failure rate is over %90." That's if you can even get the person into rehab at all! Just before last Christmas we buried a good longtime friend and colleague who'd died of liver cirrhosis. Nothing we did could get him into rehab. 'So what' you may say - he was just one more of many thousands. The trouble was that he was also an organic chemist by training yet even with th…

I have been in and out of AA (thankfully in a good place currently) and I think this idea that addicts are fundamentally different from everyone else is a complete myth that only makes people with addiction problems feel more hopeless and separate from society. Have you ever had a harmful habit you have had difficulty breaking, or been unable to do something that you know will improve your health? Then you can relate to an addict. Their habit is likely a lot more harmful than yours, and affects their brain chemistry, but it’s the same mechanism that prevents you both from stopping even though you know it would help you.

Judson Brewer is a psychiatrist and neuroscientist who researches addiction and advocates this view. I found his book The Craving Mind[1] to be incredibly illuminating and true to my experience as a person who has struggled with drug use.

[1] https://yalebooks.yale.edu/book/9780300234367/craving-mind/

Re: A drug that cures alcoholism may be the next anti-anxiety medication

#154

Earlier quoted context omitted.

"Rehab: Good short term, bad long term. Rehab failure rate is over %90." That's if you can even get the person into rehab at all! Just before last Christmas we buried a good longtime friend and colleague who'd died of liver cirrhosis. Nothing we did could get him into rehab. 'So what' you may say - he was just one more of many thousands. The trouble was that he was also an organic chemist by training yet even with th…

>”I find the effect of even a little alcohol both disturbing and mind-dulling and I deliberately avoid getting into that state. On the other hand, the alcoholic either experiences different physical effects from alcohol than I do and or his/her visceral perception of those physical effects of the alcohol are very different to mine.” As an alcoholic I think an often overlooked aspect is the opposite of this: how it fe…

Right, what you said makes sense. Essentially, it's the same thing, that is, we're feeling at our best in opposite states.

My perception of the world and state of mind seems better to me sans ethanol, yours is the opposite. But that doesn't mean it's a bed of roses for me, it's just that ethanol doesn't work for me to make things better. This is a very complex matter of which millions of words have already been written and clearly I'm not going to come up with any new insights.

What I've tried to say is that these differering worldviews make it difficult to make life easier for alcoholics.

It's strange really why different people have such different responses to alcohol. Despite what I said about the negative effects of alcohol on me I nevertheless love the taste of good wine and I reckon it's a damn cruel act of fate that alcoholic drinks are so nice and yet at the same time alcohol is far from being just another innocuous additive.

Trouble is that the level of alcohol in many alcoholic drinks has increased in recent years when it ought to have been decreasing. For example, a top Bordeaux traditionally has 12.5% alcohol-that is, the world's best wine needs only that amount of alcohol, yet on the shelves of liquor stores where I live almost all wines now have 14.5% or more alcohol. It used not be like this but winemakers found that if they increased the level of alcohol then the wines needed almost no ageing and could be turned over more quickly.

That's a sore point with me, wines may be sold more quickly by increasing their alcohol content but good wines must still be aged. Again the quick buck has gotten in the way of better health and governments have done stuff-all about it.

I hope that alcohol eventually becomes much less of a problem for you.

Re: A drug that cures alcoholism may be the next anti-anxiety medication

#155
post #74

Earlier quoted context omitted.

Thank you. This kind of easy to follow step-by-step breakdown of the method section should be included as an obligatory abstract of its own if one really is willing about improving the readability for people outside of the field. It actually takes a lot of time (most people don't have) in identifying all the technical terms and then to recognize what their actual experiments/basis were so that one can actually follow…

It’s not for lay people. It’s a technical paper. No different than saying anyone should be able to read the source code of Apache.

Oh it is much easier than that- just check sex and age and strain and ask yourself if these three variables in any rodent study are handled well in human-readable form.

Re: A drug that cures alcoholism may be the next anti-anxiety medication

#156

Earlier quoted context omitted.

"Antabuse can lead to death or dangerous health problems." So can a slew of other drugs. You should see the drug risks for stuff folks take for autoimmune disorders. It isn't just up to the doctor to mitigate the risks: Patients must do their part as well (blood tests and so on). And most importantly: So can alcoholism. Alcoholism kills slowly. Withdrawal can kill not-so-slowly. Somehow, do you think the doctor is no…

> So can a slew of other drugs Dr isn't legally liable for drugs you find on your own.

Dr. isn't legally liable if they act within the norms of the profession with with informed consent. Almost any drug can cause death or dangerous health problems.

Re: A drug that cures alcoholism may be the next anti-anxiety medication

#157
post #119

Earlier quoted context omitted.

"I urge people who have a problem with drinking and wish to quit, who for whatever reason do not feel that 12 step programs like Alcoholics Anonymous" I urge people to see an addiction specialist first. Do not see AA first. See a doctor asap. This disease is serious and has a high fatality rate. AA meetings are like a club after you have it under control (EG. don't attend drunk). Disulfiram: An old military drug. Thi…

> You will be rejected literally by tens of potential sponsors until one says yes (hang in there!) That's not true at all, but it's a club with millions of people. Other than that appreciate your breakdown.

I think s/he meant that finding a sponsor with whom you have a good rapport and willing to give you the time you need is the difficult part (hence, like "dating").

Re: A drug that cures alcoholism may be the next anti-anxiety medication

#158

Earlier quoted context omitted.

Did you ever get a chance to talk to your dad about the illness and the drugs effect on him personally? Did it take awhile to convince him to take it given his stoic nature?

No not really but he was aware of the beneficial effects of the drugs for his lungs, and for his rheumatoid arthritis. But near the end he was also on morphine to help his breathing which was great but it's a terrible drug for causing constipation! His mind was clear up until the last two months because he was in the hospital and then palliative care. So that was not unexpected to be said since he'd never be home aga…

Thanks for sharing. Wishing you well. I'm sure it took a lot just to type a response. Thanks again.

Re: A drug that cures alcoholism may be the next anti-anxiety medication

#159

Earlier quoted context omitted.

My recollection is that accumulation of aldehyde is also the danger of consuming methanol.

> My recollection is that accumulation of aldehyde is also the danger of consuming methanol. I assume you mean ethanol, because methanol is highly poisonous (even a fraction of a shot will make you go blind). But yes, alcohol is broken down into acetaldehyde.

No, my recollection was that methanol is metabolized into something which “pickles” you but I may well be wrong.

Re: A drug that cures alcoholism may be the next anti-anxiety medication

#160
post #57

Earlier quoted context omitted.

Interesting side note, shaggy mane mushroom has a similar effect to disulfuram.

I think you mean Coprinopsis atramentaria, common name Inkycap, not the similar Coprinus comatus (Shaggymane).

Ah, true.

A search brought up this interesting thing.

https://pubmed.ncbi.nlm.nih.gov/34347998/

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