I recommend tinnitustreatmentreport.com for news and updates for tinnitus.
Reversing hearing loss with regenerative therapy
101–110 of 215 posts
Re: Reversing hearing loss with regenerative therapy
#102We recently learned that my daughter is completely deaf in one ear. She is a very happy healthy girl otherwise, but it makes me sad to know that currently we have no therapy and she could live her whole life like this. But maybe there will be something for her in a few years.
Hey, I completely lost my hearing in one ear about five years ago. I'm sorry to hear about your daughter. But I'd encourage you not to be too worried about it. Personally, I only notice it in very loud situations in which someone is speaking to me on my deaf side; otherwise the sound bounces around and reaches my working ear anyway. I don't feel "disabled" in any way. In fact I rarely think about it. I've been given…
I'll keep this in mind. I've heard some scary things about falling behind in school and having difficulty in noisy social situations... but it sounds like there's a lot of variation in how well people cope, and she's coping extremely well so far.
Re: Reversing hearing loss with regenerative therapy
#103Earlier quoted context omitted.
> Although exciting, we also need to remember that translatability rates from animal models to humans is notoriously low, usually in the single digits for most therapeutic areas. This is true of humans as well -- there are plenty of programs that get interesting and clear results in Phase 2 (the dose ranging phase: essentially "what dosage is most efficacious") that die in Phase 3 (roughly: "OK, how does that dose re…
It's also hard to figure out just how the animal's hearing is improving (you can't simply ask) This seems relatively easy, right? Play a sound at a given frequency, associate it with a food reward. Like Pavlov's dog, but vary the frequency of the bell. Oversimplification obviously, and "easy" is extreme relative to all the other hard parts involved but that part seems very doable
Well, there's more to it than binary to text you. I agree with you, in that the signaling perception is probably easy. However, let's say that that frequency is coupled with several others, making for noise for poor discrimination.
For that kind of thing, we're going to need real people who can communicate in detail.
Re: Reversing hearing loss with regenerative therapy
#104There's a crazy amount of problems that are due to hearing loss. There's an increased risk of dementia. Even for balance from hearing audio cues when walking. My mother has poor hearing and she refuses to get a hearing aid mainly due to cost. They are ~$4K per ear she doesn't have the money but to her an elderly person she imagines it as $40K/ear. I also fear dementia has already begun for her. For me I have tinnitus…
Where do you live? There are many, MANY different kinds of hearings in many different price ranges. I have a top of the line OPN 1 and it was 3,000$. There are cheaper versions for 2k. Many manufacturers produce models under 2k. I'd advise to have her check again, perhaps with a different audiologist.
Heck, if she gets an earmold, I can give her my old Oticon Chili. I bet there are other avenues to procure a cheap one.
Re: Reversing hearing loss with regenerative therapy
#105Earlier quoted context omitted.
I have increasing;y bad tinnitus. Will this help with that? I hear a permanent and constant low-volume very high pitch "squeal" in my ears at all times, I was never a big loud music listener, and I have always brought ear-plugs to loud events - and have had no big ear-rupturing moments (such as a gun firing close to my head without protection etc...
My personal albeit anecdotal evidence is that certain foods, or possibly too much sodium, can cause tinnitus. When I have tinnitus I drink a lot of water and reduce my sodium intake - I think that acesulfame postassium (NutraSweet) can cause it for me as well. You might want to experiment with changing your diet, drinking more water, etc.
I'm pretty sure you are spot on with Sodium:
I do eat a lot of sodium, but here is an interesting anecdote:
A friend's husband had Lyme Disease - and had very bad veritgo from it which was exacerbated by a high sodium intake (I assume the ear works on the sodium potassium pump in some manner?)
but she used to have to make a very careful diet for him so as to remove sodium as much as possible, which would prevent his vertigo.
Re: Reversing hearing loss with regenerative therapy
#106The article says the treatment focuses on increased speech intelligibility. Speech, depending on how you define it, can occupy a fairly narrow range of the audio spectrum that humans can perceive. My hearing loss is mostly on the high end (10-12K and above) and impedes my ability to hear speech in noisy environments. More troubling has been the inability to enjoy music/sound in those upper ranges, resulting in the mu…
I tend to listen to instrumental music. In part that's because I play an instrument, and in part it's likely due to hearing loss making words not that easy to understand. I also find I prefer vocals in foreign languages since there's no point in trying to understand them.
There's still plenty of good music out there.
I also find that my hearing aids aren't great for music due to how much they change timbre from boosting the high end, so I use regular ear buds instead.
Re: Reversing hearing loss with regenerative therapy
#107Earlier quoted context omitted.
It's also hard to figure out just how the animal's hearing is improving (you can't simply ask) This seems relatively easy, right? Play a sound at a given frequency, associate it with a food reward. Like Pavlov's dog, but vary the frequency of the bell. Oversimplification obviously, and "easy" is extreme relative to all the other hard parts involved but that part seems very doable
Well, there's more to it than binary to text you. I agree with you, in that the signaling perception is probably easy. However, let's say that that frequency is coupled with several others, making for noise for poor discrimination. For that kind of thing, we're going to need real people who can communicate in detail.
Yeah, fitting and tuning a hearing aid is quite complicated, and there are intelligent people at both sides of the process.
Re: Reversing hearing loss with regenerative therapy
#108Earlier quoted context omitted.
> Although exciting, we also need to remember that translatability rates from animal models to humans is notoriously low, usually in the single digits for most therapeutic areas. This is true of humans as well -- there are plenty of programs that get interesting and clear results in Phase 2 (the dose ranging phase: essentially "what dosage is most efficacious") that die in Phase 3 (roughly: "OK, how does that dose re…
It's also hard to figure out just how the animal's hearing is improving (you can't simply ask) This seems relatively easy, right? Play a sound at a given frequency, associate it with a food reward. Like Pavlov's dog, but vary the frequency of the bell. Oversimplification obviously, and "easy" is extreme relative to all the other hard parts involved but that part seems very doable
One sobering lesson from my time working in the life sciences is that everything is insanely complex and once you've isolated everything in your problem space into a small, relatively isolated set, you still end up with an insanely complex space.
Essentially it's fractally complex.
Re: Reversing hearing loss with regenerative therapy
#109What the heck is going on with tinnitus? https://trends.google.com/trends/explore?date=all&geo=US&q=%... I’ve been afflicted with tinnitus after a mild covid case in January and now that I’m looking it seems like this is a growing problem. So many comments here about tinnitus.
Airpods maybe?
Re: Reversing hearing loss with regenerative therapy
#110Earlier quoted context omitted.
I've got pretty bad - although not constant - tinnitus in my left ear after a particularly loud NYE too late in life. What I find interesting though, is that I distinctly remember as a young kid living in the countryside that I found it impossible to hear absolute silence. I distinctly remember sitting on a bale of hay on a bright summer's day with not even a breeze and the quieter I perceived things, the louder a 'T…
I had the same experience when visiting an anechoic chamber. I think the explanation is that without external stimuli, your brain cranks up the input gain to the max, at which point you begin to hear the ambient "neural noise" from your auditory circuitry. People taking DMT or ayahuasca also often experience an extremely high-pitched sound as the drug kicks in, which also suggests a neurological basis for the phenome…
I must try an anechoic chamber one day - I must!
I never got the 'nee-naw nee-naws' from DMT or Ayahuasca when I did such things, but I absolutely did when going deep on Nitrous Oxide. DMT was always entirely (and oh my gosh so absolutely) visual for me.