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Ask HN: Beating depression with or without anti-depressants?

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Re: Ask HN: Beating depression with or without anti-depressants?

#101

This is my story. I hope it helps. A few years ago now, I went through the most traumatic experience of my life. In a moment, all of my thoughts about how life was, is or was going to be were shattered. I didn't sleep a full night for about a year following. From that moment on, I was in the grips of the most terrible depression - mixed with anxiety - I've ever faced. I woke up every day feeling that my life was wort…

Thank you for your story, I'm glad you are in a better place now.

> without needing to saturate myself with intense stimuli (ie: competitive video games) just to keep the rumination at bay

I can relate to this so much. I have racked up countless hours (literal thousands...) on competitive games over the last decade or so, mostly as a coping mechanism. I have stopped a bunch of times because I realized even if I was good at these games I didn't actually enjoy them, I just played them because they masked the other things I was feeling.

Re: Ask HN: Beating depression with or without anti-depressants?

#102

> For these reasons I am completely shit-scared of them. I see them as my option of last resort but increasingly I feel my options running out. I was in the same boat. Don't listen to the haters. Anti-depressants are amazing. Most of the people who 'cured' their depression through some kind of cheap trick turn out to have been self-diagnosed. Anti-depressants, if dosed and chosen properly, have basically no side effe…

> Anti-depressants, if dosed and chosen properly, have basically no side effects WTF is that bullshit ? SSRIs destroy libido and possibly permanently (see r/pssd) MAOIs have many side effects NRIs are not effective NDRIs can cause tinnitus. Stims are cardiotoxic and usually not prescribed for depression. TCAs are not an action mechanism and therefore fall in the above categories. Atypical mechanisms are not better ei…

This is the reason why some people suggest not to listening to any comments. A lot of stuff here are factually incorrect:

  1) MAOIs are safe, and Parnate specifically is extremely effective. However, requires a special diet to adhere.
  2) Stimulants ARE prescribed very frequently to augment antidepressants in difficult cases, especially in people with serious illness.
  3) Moclobemide has every effect of an MAOI in effective dosages, including diet restriction. There are no effective drugs without side effects. Moclobemide is not thought to be particularly effective(mostly because on-label dosage is far too low), there is a reason why it's used infrequently.
  4) Etifoxine might be great for some, but it has significant risks of liver injury. There is a reason why Valium is still one of the most common anxiolytics prescribed worldwide.

Re: Ask HN: Beating depression with or without anti-depressants?

#103
One thing to highlight: there's no "beating" depression--setting that as the goal will be discouraging. But as you alluded to, there are ways to cope, and to manage it, and to live a good + fulfilling life in spite of the depression.

I've had great luck with antidepressants. They don't "solve" the problem, but they give me a bit more space to operate and work on my mental health. As others have said, symptoms of SSRIs can be managed.

Mindfulness meditation--clearing your thoughts and focusing on breathing--for 15min a day can feel transformative after a couple months. I've fallen off that, but I'd like to pick it back up.

There's lots of little things that can contribute to better mental health. Meditation, exercise, diet, sleep: all are factors. But it's not worth suffering through, and it's worth giving medication a shot (in my opinion).

Medication is not a commitment for life, it's an experiment to see if you can find something to help your symptoms.

I do _highly_ recommend sustaining a therapy relationship, and simultaneously working with a psychiatrist. I haven't found therapy very transformative, and it certainly hasn't solved my problems. But it does give me some support, and that's yet another helpful factor in getting by.

Re: Ask HN: Beating depression with or without anti-depressants?

#104

Earlier quoted context omitted.

Doctors aren't always effective at treating depression. Especially if they use a therapy modality or medication that doesn't work for you. That doesn't mean you shouldn't talk to them, but it's also helpful to read experiences from from other people. My opinion, doing both is good. Consult a professional and read about other people's experiences. At the very least maybe somebody mentions a form of therapy that you've…

50% of doctors are by definition below the average. In reality, roughly 3-10% are good, the rest just go by standard guidelines only and/or punt you off to someone else.

50% are below the median.

Re: Ask HN: Beating depression with or without anti-depressants?

#105
My data point: I've been on Paroxetine for 20 years for really bad OCD and associated depression. Yea, the side effects suck, but they're a cake walk compared to the OCD and the depression. Do what others in here have said though, talk to a professional.

Re: Ask HN: Beating depression with or without anti-depressants?

#106

PLEASE do not read any of these people's advice. Talk to a MEDICAL PROFESSIONAL, preferably a DOCTOR. DO NOT trust your mental health to strangers on the internet, be it reddit, or hacker news, or whatever. If you are based in the US and live nearby a university they usually have good counseling services and the infrastructure to refer people even if you're not attending the school. Search "{school} counseling servic…

Sorry, you are very very wrong about this. Have you ever talked to a _medical_ professional about depression or any mental health issue? They generally don't know what they're doing. Medical professionals only have one tool in their arsenal for depression: antidepressants. So a medical doctor will likely prescribe them, whether that's appropriate or not. Antidepressants are no joke. Sometimes they can help, but they can also cause really strange side effects, like increasing the possibility of suicide. And does the average doctor monitor all their patients regularly to make sure they're not having suicidal thoughts? Nope. And doctors generally won't know anything about the difficulty of getting _off_ the antidepressant if it didn't work.

Asking for advice on the internet is a very valid strategy, given the terrible state of mental health care in the US.

Re: Ask HN: Beating depression with or without anti-depressants?

#107
1. There are genetic markers that can inform the choice of medication for depression. We are starting to see better effectiveness than just the shotgun try each one until you find an option without too many side effects.

2. I took Prozac for a 3-4 years and felt like it helped a bit, and I had very limited side effects - even good side effects. A close friend is trying Zoloft/Stratera and is having annoying side effects like muscle spasms during the first month, but those are reducing.

3. Therapy even more important than medication. Try a different therapy methodology. If it doesn’t stick for you, try adding SSRI or similar. You can always stop taking the drug.

Re: Ask HN: Beating depression with or without anti-depressants?

#108

PLEASE do not read any of these people's advice. Talk to a MEDICAL PROFESSIONAL, preferably a DOCTOR. DO NOT trust your mental health to strangers on the internet, be it reddit, or hacker news, or whatever. If you are based in the US and live nearby a university they usually have good counseling services and the infrastructure to refer people even if you're not attending the school. Search "{school} counseling servic…

I found strangers online to be more effective than doctors, simply because they read to much on the matter, then they interact too much with you.

I basically got diagnosed online by 2 different people about 2 different issues, one is biological, and the other is mental. And they were right. This is nerds out there who read about topics constantly, way more than the average doctor, not even close. So a stranger can help.

Also depends on where you are located, doctors can be dogmatic, there is countries that give antibiotics before extracting teeth, and there is those who don't. Countries who believe ADHD can stay into adulthood and go undiagnosed, and others who believe it is impossible to have ADHD as an adult.

In the ADHD case, depends on who what countries are right, some group might be living a lie taking meds for an illness that doesn't exist, or the other group is suffering being undiagnosed with ADHD despite seeking help, the doctor just tell them its not possible to have ADHD.

I would rather research and try to solve my issues over hand my situation to the medical zeitgeist of my country. Also I am sure if I give myself days of research, thinking, talking to people, comparing situations over some doctor talking to me for 15 minutes then giving me the two meds given to everyone who enter that door (SSRIs and benzos), I might probably be up into something.

I will never stop researching my medical issues, I will never trust my doctors fully, I will always google, research, ask, ask second opinions. Some doctors care more than others, some doctors are capable more than others, you have no idea which ones the RNG gave you.

Re: Ask HN: Beating depression with or without anti-depressants?

#109
Not all drugs are created equal.

I've been on Welbutrin for about four years now; absolutely life-changing; not an SSRI, so really minimal side effects. 10/10, will take again.

Welbutrin is really special. It's not an SSRI, it's not a TCA. It's an NDRI https://en.wikipedia.org/wiki/Norepinephrine%E2%80%93dopamin... and there aren't a whole lot of others like it.

Re: Ask HN: Beating depression with or without anti-depressants?

#110
Here is a little meditation I wrote a while ago on my depression and my medication that still rings true for me.

https://dhubris.livejournal.com/14447.html

I don't know about your part of the world, but in Australia you may find a good GP (doctor who is a general practitioner) who can handle the medication process with you, or see a psychiatrist who usually has more expertise in this area.

Either way it can be a bit of a trial and error process until you find what works for you (which may be different than what works for me or others). Usually four to six weeks before medication reaches full effectiveness. If the medical professional writes you out a prescription without organising a follow up to see how well it is working, tear up the script and find another doc. Don't stop a medication cold turkey. Ramp down dosage under medical guidance.

Good luck!

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