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Rare genital defects seen in sons of men taking major diabetes drug

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231–234 of 234 posts

Re: Rare genital defects seen in sons of men taking major diabetes drug

#231
post #217

Earlier quoted context omitted.

For finasteride I agree, as it decreases DHT, which is not exactly a useless hormone. It shouldn't be prescribed to anyone, as you have said. I don't necessarily agree for the Viagra/Cialis. Generally cialis is safer than viagra, with less side effects. But their mechanism of action is quite simple and doesn't cascade to a lot of other body functions, inhibition of PDE5. Viagra also inhibits PDE6 more, thats why you…

> If you can get an erection in the morning, while you're sleeping, PDE5 inhibitors won't help. Did you mean to say can’t?

Nope. If you can get an erection in the morning, the vasodilatation mechanism works, so Cialis/Viagra won't help. If the mechanism works, but you still cannot get an erection when you're with your partner, the problem could be psychological, say you're not attracted anymore to your partner, anxiety, stress, all stopping you from getting aroused. And you need those neurons or endotheliums to fire. Another example is drugs that are vasoconstricting, stimulants like amphetamines or cocaine, which even though create a high arousal state, they are so vasocontricting that it's hard to achieve an erection (so Cialis/Viagra helps, but it's not indicated to combine drugs that combat eachother).

Re: Rare genital defects seen in sons of men taking major diabetes drug

#232
post #217

Earlier quoted context omitted.

> If you can get an erection in the morning, while you're sleeping, PDE5 inhibitors won't help. Did you mean to say can’t?

Nope. If you can get an erection in the morning, the vasodilatation mechanism works, so Cialis/Viagra won't help. If the mechanism works, but you still cannot get an erection when you're with your partner, the problem could be psychological, say you're not attracted anymore to your partner, anxiety, stress, all stopping you from getting aroused. And you need those neurons or endotheliums to fire. Another example is d…

Interesting, and thank you for the clarification.

I think it’s probably more of a spectrum and not a binary thing, and so you can have layers of physiological and psychological impediments, and one could also feed the other.

Re: Rare genital defects seen in sons of men taking major diabetes drug

#233

I'm 26 and have been on Metformin for almost a decade at this point and will probably be on it until I die. Thankfully though, children are not in my future.

Please get your serum zinc levels tested. I am saying this from experience and knowledge.

I'm obese and of south asian ancestry, so there's no real question as to why my insulin sensitivity is shot, but I'll add zinc to the list next time I do bloodwork.

Re: Rare genital defects seen in sons of men taking major diabetes drug

#234
post #102

Earlier quoted context omitted.

> it should (speaking of an idealised utopian world) be easy to get refills of medications that have been appropriately prescribed. I must be living in Utopia then, I thought it was Norway! :-) When I run out of my blood pressure pills I can spend a couple of minutes online to send a message to my doctor. He spends a few seconds online to renew my prescription and then I can go to any pharmacy to pick up three months…

I have a similar set up in the UK - I hit the "request repeat prescription" button in my GP's app, they nod it through and send it to my chosen pharmacy, then a nice person from the pharmacy delivers it the next day. No shady business models required! :D

The difference is that I don't have to specify which chemist, I can go to any one and just present my ID, they can then look up the prescriptions.
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