Christianity without tears?
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Ketamine for the acute treatment of severe suicidal ideation
111–120 of 120 posts
Re: Ketamine for the acute treatment of severe suicidal ideation
#112Re: Ketamine for the acute treatment of severe suicidal ideation
#113Earlier quoted context omitted.
Any issues with your bladder? Have doctors mentioned anything about the potential damage to the urinary system? This seems to be the scariest side effect.
This is part of the reason MXE was developed. Love me some MXE.
It's a shame it doesn't exist anymore. It would be great for this exact purpose
Re: Ketamine for the acute treatment of severe suicidal ideation
#114FYI: Johnson & Johnson patented the S(+) enantiomer of ketamine and sells it as a nasal spray called Spavato. It's been FDA approved for depression since 2019. Although Spravato costs more on paper than regular ketamine, it's often less expensive for patients since it is covered by insurance (regular ketamine treatments are considered an off-label use and are usually not covered).
It's pretty awful though for a lot of people. Researchers outside of the US have published studies showing that s-ketamine has higher risk of dependency in animal experiments and lower long term efficacy for depression, like on par with placebo. If I'm remembering right there are a number of reasons for this and one of them is that r-ketamine seems to simulate neuroplasticity better, something related to BDNF in cert…
Yea, I agree. I wish there was some kind of organization that would seek FDA approval for racemic ketamine treatment of depression. It's cheap, and widely available. Unfortunately, without the incentive for a patentable product, it's unlikely to ever happen.
Re: Ketamine for the acute treatment of severe suicidal ideation
#115> Then, patients received a first 40 minute intravenous infusion of ketamine (0.5 mg/kg) or placebo 0.9% (saline solution) in addition to their current treatment. This really shouldn’t be labeled as double blind. 1.The nurse administering knew if it was placebo or active (for safety reasons). 2. It would immediately become obvious to the subject if they were injected with salt water or ketamine. 3. Within minutes it…
0.5mg/kg spread out over 40 minutes wouldn’t be as dramatic as you’re suggesting. > 3. Within minutes it would become obvious to everyone in the room if the patient was injected with salt water or ketamine. I think you’re mistaking IV infusion for injection. The dose is given slowly over 40 minutes, not as a rapid injection. The patient would barely have any of the drug in their system in the first few minutes. Given…
My personal experience suggests otherwise.
In the sessions I had with IV ketamine, it is very, very noticeable and fairly trippy. The eye mask and the music certainly help, but the ketamine is inducing some crazy sensations.
I don’t remember the exact dosages I received, but I remember it being in line with what I saw others reporting online from their experiences at a clinic.
Re: Ketamine for the acute treatment of severe suicidal ideation
#116Earlier quoted context omitted.
Absolutely, I have a partner who has had severe PTSD and went through a great month-long program, she's overcome many longstanding fears and triggers and has made huge strides in being able to feel that she is living her life once again.
I have a close acquaintance who uses ketamine to manage depression and Complex PTSD. My experience as a bystander is that the depressive symptoms reoccur periodically regardless of the use of ketamine. The depressive symptoms seem to be caused by the PTSD, and ketamine does not seem to alleviate the PTSD. I'm saying this as a huge fan of the positive impact of ketamine. There are some symptoms that seem like they nee…
C-PTSD is probably the simplest way to summarize what I’ve been dealing with (I’m not totally comfortable with the label).
I’ve done 20 ketamine sessions over the past 2 years (the last one about 5 months ago). I agree with you that a lot of the immediate relief from an infusion can fade after not that long. However, combined with some of the other work I was doing there was a slow accumulation of benefits and new perspectives on life.
Overall, the infusions definitely helped… it hasn’t been easy going though, and I have been continuing to work on myself.
A few months ago, I finally found a therapist who I felt was actually helping me. I had tried a few different therapists in years past and it wasn’t that helpful. My current therapist uses a lot of “somatic therapy” in her work, which I think is really important. With trauma, talk alone won’t get you very far.
I’ve made a lot of progress since November when I started seeing her. I think the Ketamine and the work I had been doing on my on own “prepped” me in a certain sense.
Your friend might benefit from finding a good somatic therapist.
Re: Ketamine for the acute treatment of severe suicidal ideation
#117Re: Ketamine for the acute treatment of severe suicidal ideation
#118Earlier quoted context omitted.
Are you getting it all at once or as an infusion? Considering this is given as an infusion over 40 minutes, this seems to be a pretty mild dose consistent with mild analgesia and well bellow the recreation and dissociative doses based on all the charts I just pulled up, but I'm not personally experienced with K ;)
I've had K infusions for neuropathic pain, in comparable dosage rates, for up to 7 days at a time. You certainly notice the effects of IV K. So do other people when you start to talk to a hairbrush. It's a bit draining after a few days though, and not terribly fun.
Would you still have noticed the effects if you were just supposed to lie still in a dark and quiet room while the infusion was happening?
Re: Ketamine for the acute treatment of severe suicidal ideation
#119Earlier quoted context omitted.
The nurse administering it is most certainly liable for what s/he administers. It is a very big no-no to blindly administer a medication of which you cannot reasonably verify what it is. To push a syringe or start a pump of something that "could be ketamine, or could be NS" is walking an uncomfortable line for your license to practice nursing. Right patient, right medication, right dose, right route, right time. If y…
>Right patient, right medication, right dose, right route, right time Can't you achieve all of those by having someone else create the bag and then label it for the patient. The "right medication" is the one they're receiving as part of the study. It's not like what they need to do is different if it's ketamine or saline.
The parent comment is absolutely correct. This is salt in the medical community by having a nurse that knows exactly what the patient is getting and a different clinician doing the assessment