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Treatment for Tinnitus with Stimulation of Auditory and Non-Auditory Nerves

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Re: Treatment for Tinnitus with Stimulation of Auditory and Non-Auditory Nerves

#111

Post by nosianu »

wruza wrote: post #63
nosianu wrote: post #46

Earlier quoted context omitted.

Just to say that in advance, although I'm a CS guy, I also have quite a bit of background in life sciences, so what I'm saying is not from someone naive about bio-chem or physiology. I got rid of my tinnitus - which was not even the goal, it was not too bad compared to all the many other issues I increasingly had and which forced my hand - after removing the remaining amalgam fillings in my teeth and starting chelati…

Not a downvoter, but for me this comment was hard to read, grasp and squeeze the sense of.

Really? Okay, so TL;DR Heavy metals == bad and can be a factor for tinnitus. Which is why I wrote a comment, the overall subject is tinnitus after all? The rest of the comment is to provide the greater context and more info. I mention that I got rid of my tinnitus right at the start, showing how it's relevant for the current discussion.

Re: Treatment for Tinnitus with Stimulation of Auditory and Non-Auditory Nerves

#112

Post by nosianu »

dataangel wrote: post #81
nosianu wrote: post #46

Earlier quoted context omitted.

Just to say that in advance, although I'm a CS guy, I also have quite a bit of background in life sciences, so what I'm saying is not from someone naive about bio-chem or physiology. I got rid of my tinnitus - which was not even the goal, it was not too bad compared to all the many other issues I increasingly had and which forced my hand - after removing the remaining amalgam fillings in my teeth and starting chelati…

How did you determine you needed chelation to begin with? Did you get Mercury levels tested, and if so what made you think to do that in the first place?

I didn't, originally, the doctor determined it after the lab tests came back, which included heavy metal tests. He said I'm in a gray area and he could justify starting chelation, but he thought that explained only some of my issues and I should have something else. He never found anything else and chelation had FAR more success than anticipated by either him or me.

I did have a hint before that: after a health escalation I suffered - visibly even (mouth) - from Candida. I even was prescribed, as I wrote, a systemic drug, which no doctor would ever subscribe for the "psyche" because that is serious stuff impacting the liver (and as I wrote, I got quite yellow after those two, or was it three?, weeks - but a lot of bowel issues and the feeling in my mouth were just gone). The problem: Candida has a deeper cause. It's immune compromised people. But there was nothing for me, and the only thing I found was heavy metals. So I went to a university clinic and got tested. Fortunately it showed up in the blood and urine tests, which is not a given if you have low-level long-term exposure and have most of the burden intracellular and/or stored away instead of moving around.

Re: Treatment for Tinnitus with Stimulation of Auditory and Non-Auditory Nerves

#113

Post by philliphaydon »

The_rationalist wrote: post #89
philliphaydon wrote: post #84

Earlier quoted context omitted.

I've never heard of this.. https://en.wikipedia.org/wiki/Fludiazepam Is this the same? I'm in Taiwan so googling to figure out what i could ask the pharmacist for to try.

[dead]

Ok, I really really appreciate the response, I will do some research and see what I can find here.

Re: Treatment for Tinnitus with Stimulation of Auditory and Non-Auditory Nerves

#114

Post by The_rationalist »

FollowingTheDao wrote: post #108
The_rationalist wrote: post #92

Earlier quoted context omitted.

> Any increase in GABA will counteract the excitatory transmission of Glutamate. That is all that matters. No that is not all that matters. The main effect of tofizopam is unrelated to GABAergy, the fact it indirectly modulate GABA-A and potentiate benzos is a plus but its main effect come from atypical PDE inhibition. Look if klonopin is viable for you and solve your tinnitus that's great to hear. But for many peopl…

> The main effect of tofizopam is unrelated to GABAergy It's a antagonist of the AMPA receptor. I am not saying it has anything to do with GABA-A but it enhances the action of GABA. https://www.nature.com/articles/nn0600_551 >By taking a classical benzo like klonopin you increase your GABA-A level which inhibit the overload of excitation (GLUT). No, Klonopin does not increase GABA, it attaches to the GABA-A receptor…

I have not found information saying that tofisopam is an AMPA antagonist. But you are probably right, the answer must be on the paper you link I guess. Nevertheless the action on PDEs is what makes tofisopam unique.

> No, Klonopin does not increase GABA Yeah that's right. GABA releasing agent, GABA reuptake inhibitor and GABA transaminase inhibitors do exists but benzos have not those properties. They are GABA-A positive allosteric modulators (they are not agonists although GABA agonists do exist too). So yeah they potentiate GABA functionally without increasing its quantity directly.

Re: Treatment for Tinnitus with Stimulation of Auditory and Non-Auditory Nerves

#116

Post by tptacek »

FollowingTheDao wrote: post #106
tptacek wrote: post #99

Earlier quoted context omitted.

I've been IF for several years now (for whatever good it's done me!), sometimes very strictly and sometimes casually, and I've noticed no correlation whatsoever to my tinnitus. I do buy that anything that really reduces inflammation or anything like that could help, because my tinnitus is definitely correlated to ear congestion and sinus inflammation (but it's always there at some level no matter what). Basically, my…

Not al tinnitus is caused by the same process, and some nerve damage might be permanent. My tinnitus was not caused by loud sounds and I have had it since I was a kid. My body is not "efficient" in dealing with glutamate, which is why I need klonopin and also why some people have seizures. https://pubmed.ncbi.nlm.nih.gov/7970002/ I wish people will finally understand that we are not all the same genetically and it is…

The first article is a rat study.

The second makes no mention of glutamates; rather, it's about ketogenic diets (a well-known strategy for managing epilepsy), which tend to be higher in glutamates (cheese, nuts, meats, &c). There's evidence that ketogenic diets alter brain metabolism of glutamate, but that's not the same thing as evidence that dietary intake of glutamates has an impact.

Re: Treatment for Tinnitus with Stimulation of Auditory and Non-Auditory Nerves

#117

Post by wruza »

nosianu wrote: post #111
wruza wrote: post #63

Earlier quoted context omitted.

Not a downvoter, but for me this comment was hard to read, grasp and squeeze the sense of.

Really? Okay, so TL;DR Heavy metals == bad and can be a factor for tinnitus. Which is why I wrote a comment, the overall subject is tinnitus after all? The rest of the comment is to provide the greater context and more info. I mention that I got rid of my tinnitus right at the start, showing how it's relevant for the current discussion.

For how long?

Asking that because I also got rid of my tinnitus right at the start for few months, then a year later for a couple of weeks, and now waiting for statistics on its dependency on medications that I try from time to time. Mine is psycho/bloodvessel related - when I stop taking one of these two sorts of pills, it changes its “volume” and “awareness threshold” levels.

Re: Treatment for Tinnitus with Stimulation of Auditory and Non-Auditory Nerves

#118

Post by quantum_magpie »

clsec wrote: post #83
quantum_magpie wrote: post #53

Earlier quoted context omitted.

I concur with the experiences of GP. It is torture. I got mine because of being stupid around power tools more than 10 years ago, for the first 5 years it was merely an annoyance that would often drown out in the background. Lately it has progressed to insufferable nuisance. It contributes significantly to my insomnia, which is also a gateway to major depression.

I'm curious what you mean by lately? I've had low level tinnitus for >25 years that I've been able to deal with. But the morning after my second Pfizer shot I woke up and it had been turned up to 11. It now sounds like I have a miniature jet engine inside my ear. It is extremely unbearable and has been causing all kinds of anxiety, stress & depression. It's been 11 months since it got louder and I'm just now getting…

Lately is like last 3-4 years.

Re: Treatment for Tinnitus with Stimulation of Auditory and Non-Auditory Nerves

#119

Post by chakintosh »

rhino369 wrote: post #79
chakintosh wrote: post #41

Earlier quoted context omitted.

One thing is sure is that Noise-cancellinng makes tinnitus more noticeable as it's not being drown out by the environment sounds. And It also allows you to listen to music on a much lower volume, which is actually better for your ears.

I didn't even realize I had tinnitus until I used noise-canceling headphones.

same. visited the doc and he said your ears are perfect. No reason you have tinnitus but i'd swear I have it.
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