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Treatment for Tinnitus with Stimulation of Auditory and Non-Auditory Nerves

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Re: Treatment for Tinnitus with Stimulation of Auditory and Non-Auditory Nerves

#81

Post by dataangel »

nosianu wrote: post #46
jader201 wrote: post #16

Not sure why I click into comment threads on HN about tinnitus, hoping for positive news or anecdotes, but it’s almost always the opposite. So I’ll share my positive anecdote. I’ve dealt with it for over 10 years, and while I can’t imagine how happy I would be to find an effective treatment, I’ve learned to cope, and do what I can to protect hearing going forward. And once you realize you can cope with it, it makes f…

Just to say that in advance, although I'm a CS guy, I also have quite a bit of background in life sciences, so what I'm saying is not from someone naive about bio-chem or physiology. I got rid of my tinnitus - which was not even the goal, it was not too bad compared to all the many other issues I increasingly had and which forced my hand - after removing the remaining amalgam fillings in my teeth and starting chelati…

How did you determine you needed chelation to begin with? Did you get Mercury levels tested, and if so what made you think to do that in the first place?

Re: Treatment for Tinnitus with Stimulation of Auditory and Non-Auditory Nerves

#82

Post by it_does_follow »

jader201 wrote: post #16

Not sure why I click into comment threads on HN about tinnitus, hoping for positive news or anecdotes, but it’s almost always the opposite. So I’ll share my positive anecdote. I’ve dealt with it for over 10 years, and while I can’t imagine how happy I would be to find an effective treatment, I’ve learned to cope, and do what I can to protect hearing going forward. And once you realize you can cope with it, it makes f…

I've had tinnitus for about 20 years now and I don't notice it most of the time and when I do don't really mind it too much. The only thing I really miss is perfect silence.

One of the things I've noticed people struggle with regarding any chronic illness is constantly feeling like they are "supposed" to be feeling fine and have more distress worrying about some perceived gap between their actual life and how they imagine life should be then the ailment itself(this obviously carrier over to things other than chronic illness).

Letting go of this imagined alternative life is the biggest first step towards accepting and dealing with tinnitus. I have tinnitus the same way I have all my other features, positive and negative. That's just the life I have and there is no alternate life out there.

I do still get a kick out of the look of horror on people's faces when I tell them I've had constant, changing frequency, ringing in my ear for two decades.

Re: Treatment for Tinnitus with Stimulation of Auditory and Non-Auditory Nerves

#83

Post by clsec »

quantum_magpie wrote: post #53
syspec wrote: post #29

Earlier quoted context omitted.

That sounds really rough, I used to listen to my music very loudly when I was young and getting tinnitus is one of my fears as I get older. How did you get tinnitus? Is the loud music thing a myth? Is yours at least not getting progressively worse?

I concur with the experiences of GP. It is torture. I got mine because of being stupid around power tools more than 10 years ago, for the first 5 years it was merely an annoyance that would often drown out in the background. Lately it has progressed to insufferable nuisance. It contributes significantly to my insomnia, which is also a gateway to major depression.

I'm curious what you mean by lately?

I've had low level tinnitus for >25 years that I've been able to deal with. But the morning after my second Pfizer shot I woke up and it had been turned up to 11. It now sounds like I have a miniature jet engine inside my ear. It is extremely unbearable and has been causing all kinds of anxiety, stress & depression.

It's been 11 months since it got louder and I'm just now getting a hearing test (gotta love social healthcare).

I'm aware that this is just a correlation at this point but I have refused to get a booster of either mRNA vaccine, to which my doctor agreed. Though I did get the J&J/Jansen booster once the FDA allowed mixing vaccines.

Re: Treatment for Tinnitus with Stimulation of Auditory and Non-Auditory Nerves

#84

Post by philliphaydon »

The_rationalist wrote: post #77
FollowingTheDao wrote: post #72

Earlier quoted context omitted.

Yes, klonopin helps reduce my tinnitus. And Tofisopam drug is a different type of benzodiazepine (not for sale in the U.S. or Canada) which blocks the glutamate AMPA receptor. Glutamate excitotoxicity is at the core of tinnitus, and this is why diet also effects the strength and appearance of my tinnitus. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458046/ https://www.sciencedirect.com/science/article/abs/pii/S0378…

No, your answer makes sense but your are being fooled. Tofisopam is not a benzodiazepine. It is what we call a 2,3 benzodiazepine. This is an exception that makes it radically different than any other benzo. It does not directly bind at GABA-A like e.g klonopin and is a weaker anxyolitic. It's action mechanisms is very atypical, it acts as a PDE inhibitor, as a GABA PAM and as a dopamine presynaptic antagonist, makin…

I've never heard of this.. https://en.wikipedia.org/wiki/Fludiazepam

Is this the same? I'm in Taiwan so googling to figure out what i could ask the pharmacist for to try.

Re: Treatment for Tinnitus with Stimulation of Auditory and Non-Auditory Nerves

#85

Post by atlantas »

jader201 wrote: post #16

Not sure why I click into comment threads on HN about tinnitus, hoping for positive news or anecdotes, but it’s almost always the opposite. So I’ll share my positive anecdote. I’ve dealt with it for over 10 years, and while I can’t imagine how happy I would be to find an effective treatment, I’ve learned to cope, and do what I can to protect hearing going forward. And once you realize you can cope with it, it makes f…

Have you found what causes the bad days? I suffer from this too and haven't been able to figure out why it's worse some days than others. It seems random, but I wonder if there's a causal factor I'm just not noticing.

Re: Treatment for Tinnitus with Stimulation of Auditory and Non-Auditory Nerves

#86

Post by sylware »

This may help:

Have ~10KHz very weak tinitus in left ear, and ~70Hz stronger but still "weak" tinitus in right ear. That combined with feet/legs/hands parasthesia (vibrations mostly, aka mostly no pain). It gets seriously worse during hot summers (reached tinglings and cramps). Ruled "idiopathic" by the docs (MRI scans show nothing "significant") but back and neck seem to be the culprit. Found only one med effective on it, and that only for the first months once the med concentration in the body is "enough": Amitriptyline (dangerous stuff, 2 times I tought it was about to kill me, because it seems my current biology is very sensitive to it). Did stop taking it because of the side effects and worn out effectiveness over time (and like 0 effective during hot summers). Impact, silence is the enemy: Falling asleep happens only when exausted, and intellectual focus is challenging. Usually, I am looking for locations with some some sort of "blank noise". When the parasthesia is too strong, I walk. Basically, only activities which are strong attention attractors are ok. Mindset: Accepted my disability for the rest of my life after years of looking for the causes, and still monitoring any news about it.

Re: Treatment for Tinnitus with Stimulation of Auditory and Non-Auditory Nerves

#88

Post by FollowingTheDao »

The_rationalist wrote: post #77
FollowingTheDao wrote: post #72

Earlier quoted context omitted.

Yes, klonopin helps reduce my tinnitus. And Tofisopam drug is a different type of benzodiazepine (not for sale in the U.S. or Canada) which blocks the glutamate AMPA receptor. Glutamate excitotoxicity is at the core of tinnitus, and this is why diet also effects the strength and appearance of my tinnitus. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458046/ https://www.sciencedirect.com/science/article/abs/pii/S0378…

No, your answer makes sense but your are being fooled. Tofisopam is not a benzodiazepine. It is what we call a 2,3 benzodiazepine. This is an exception that makes it radically different than any other benzo. It does not directly bind at GABA-A like e.g klonopin and is a weaker anxyolitic. It's action mechanisms is very atypical, it acts as a PDE inhibitor, as a GABA PAM and as a dopamine presynaptic antagonist, makin…

Tofisopam is a type of benzodiazepine, yes? Benzodiazepines are depressants that enhance the effect of the GABA, and the literature suggests that tofisopam does not act on the GABA-A receptor but it does enhance the binding of other benzodiazepines to their binding sites.

Any increase in GABA will counteract the excitatory transmission of Glutamate. That is all that matters.

But I know klonopin can eliminate my Tinnitus. So if you can explain how that works go right ahead.

Re: Treatment for Tinnitus with Stimulation of Auditory and Non-Auditory Nerves

#89

Post by The_rationalist »

philliphaydon wrote: post #84
The_rationalist wrote: post #77

Earlier quoted context omitted.

No, your answer makes sense but your are being fooled. Tofisopam is not a benzodiazepine. It is what we call a 2,3 benzodiazepine. This is an exception that makes it radically different than any other benzo. It does not directly bind at GABA-A like e.g klonopin and is a weaker anxyolitic. It's action mechanisms is very atypical, it acts as a PDE inhibitor, as a GABA PAM and as a dopamine presynaptic antagonist, makin…

I've never heard of this.. https://en.wikipedia.org/wiki/Fludiazepam Is this the same? I'm in Taiwan so googling to figure out what i could ask the pharmacist for to try.

[dead]

Re: Treatment for Tinnitus with Stimulation of Auditory and Non-Auditory Nerves

#90

Post by tptacek »

FollowingTheDao wrote: post #72
The_rationalist wrote: post #59

Earlier quoted context omitted.

https://www.jstage.jst.go.jp/article/jibirin1925/82/1/82_1_1...

Yes, klonopin helps reduce my tinnitus. And Tofisopam drug is a different type of benzodiazepine (not for sale in the U.S. or Canada) which blocks the glutamate AMPA receptor. Glutamate excitotoxicity is at the core of tinnitus, and this is why diet also effects the strength and appearance of my tinnitus. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6458046/ https://www.sciencedirect.com/science/article/abs/pii/S0378…

As I understand it, diet has not all that much to do with glutamate levels. Your body very rapidly metabolizes it (they do studies where they stuff people full of glutamate while repeatedly checking their blood, and it takes a nauseating amount to see a plasma glutamate spike), and the blood-brain barrier is impermeable to glutamate.
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