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Soybean oil affects hypothalamus, causes genetic changes in mice: study (2020)

universityofcalifornia.edu

61–70 of 464 posts

Re: Soybean oil affects hypothalamus, causes genetic changes in mice: study (2020)

#61

Taking account that this is unproven in humans -- it's enough for me to avoid soybean oil, as cooking oil choice is not very important for my palate. That said, which oils would you use for frying and baking? Most high smoke point oils are, like soybean, polyunsaturated, so I'd guess that they could have some of the same (proposed) negative effects. Bonus points if the alternative is widely available (I see potential…

Peanut oil is most often recommended for Asian cuisine.

Re: Soybean oil affects hypothalamus, causes genetic changes in mice: study (2020)

#62

My understanding is that most of the oils we use are unhealthy. They are highly processed and inflammatory. The good oils are avocado oil, extra virgin olive oil and coconut oil. Is this correct?

It's more nuanced than that but you could do a lot worse than that list. Fat profile matters, and smoke point matters, e.g. olive oil is great but if you're frying stuff with it you're turning a lot of it toxic; avocado oil is better for high heat.

Re: Soybean oil affects hypothalamus, causes genetic changes in mice: study (2020)

#63
post #9

In mice . Let's temper the usual nutritional conspiracy allegations and grand proclamations of effects on humans until someone trained and knowledgable provides an interpretation of this study. Most of these rodent studies end up not being applicable to humans anyway.

Do you have a source for the claim that most studies done in mice don’t hold up? As far as I know, mice are quite a good proxy, although there are some differences. It seems like it would be a complete waste of time to study mice if most results didn’t hold.

You can start with following footnotes from https://en.wikipedia.org/wiki/Laboratory_mouse#Limitations or https://en.wikipedia.org/wiki/Animal_testing#Scientific_crit... I guess; I doubt it's possible to show what % of mouse studies hold up or don't hold up.

Re: Soybean oil affects hypothalamus, causes genetic changes in mice: study (2020)

#64
post #49
post #39

Earlier quoted context omitted.

> Soybean oil I saw this video about seed oils a few months back.[1] Some of the information there tracked stuff I have been reading for a while. Decided to switch over completely to coconut oil and ghee (clarified butter). A comment on the video that matches my view on the subject: > If you want to be healthy just do the exact opposite of everything we were told about nutrition by mainstream experts for decades [1]…

>ghee Cholesterol oxides in Indian ghee: possible cause of unexplained high risk of atherosclerosis in Indian immigrant populations: https://pubmed.ncbi.nlm.nih.gov/2887943/ "Substantial amounts of cholesterol oxides were found in ghee (12.3% of sterols), but not in fresh butter"

> Indian ghee

We have been using ghee in India for thousands of years. If immigrant Indians are having problems, they should look into what changed in their diet and lifestyle after they immigrated.

Re: Soybean oil affects hypothalamus, causes genetic changes in mice: study (2020)

#65

What products contain soybean oil? I use canola or olive oil, but not sure I've ever bought soybean oil. Is there any reason to think canola would be better?

Canola is a branding name to distract you from the fact that the oil is technically from the nearly un-marketable "rapeseed".

Re: Soybean oil affects hypothalamus, causes genetic changes in mice: study (2020)

#66

> The same UC Riverside research team found in 2015 that soybean oil induces obesity, diabetes, insulin resistance, and fatty liver in mice. Then in a 2017 study, the same group learned that if soybean oil is engineered to be low in linoleic acid, it induces less obesity and insulin resistance. > “The hypothalamus regulates body weight via your metabolism, maintains body temperature, is critical for reproduction and…

Yup. One of the best books on this topic of toxic oils is Deep Nutrition:

https://www.amazon.com/Deep-Nutrition-Your-Genes-Traditional...

Re: Soybean oil affects hypothalamus, causes genetic changes in mice: study (2020)

#67
post #62

My understanding is that most of the oils we use are unhealthy. They are highly processed and inflammatory. The good oils are avocado oil, extra virgin olive oil and coconut oil. Is this correct?

It's more nuanced than that but you could do a lot worse than that list. Fat profile matters, and smoke point matters, e.g. olive oil is great but if you're frying stuff with it you're turning a lot of it toxic; avocado oil is better for high heat.

Any word on peanut oil?

Re: Soybean oil affects hypothalamus, causes genetic changes in mice: study (2020)

#68
post #7

Earlier quoted context omitted.

Could you elaborate on that? It doesn't surprise we that "genetic changes" is used sensationally, just would like to know what is actually happening and whether it's uncommon or something pretty normal?

In the simplest terms: Gene expression constantly changes. It's a field known as epigenetics. You have tons of genes, not all of which are constantly active. You have histones in your DNA that allow certain portions to be read while others are locked away. This changes how your genes activate.

Gene expression is not just epigenetics, bacteria also obviously express genes, but largely have no epigenome.

Gene expression changes due to environmental signals, and it happens all the time.

Re: Soybean oil affects hypothalamus, causes genetic changes in mice: study (2020)

#69

> The same UC Riverside research team found in 2015 that soybean oil induces obesity, diabetes, insulin resistance, and fatty liver in mice. Then in a 2017 study, the same group learned that if soybean oil is engineered to be low in linoleic acid, it induces less obesity and insulin resistance. > “The hypothalamus regulates body weight via your metabolism, maintains body temperature, is critical for reproduction and…

From the study:

> One additional note on this study — the research team has not yet isolated which chemicals in the oil are responsible for the changes they found in the hypothalamus. But they have ruled out two candidates. It is not linoleic acid, since the modified oil also produced genetic disruptions; nor is it stigmasterol, a cholesterol-like chemical found naturally in soybean oil.

1. We're not mammals that experience torpor. That doesn't even remotely apply to us.

2. The study explicitly states this isn't lineolic acid.

3. The site you linked is a snake oils salesman who has a vested interest in you buying their products and living the lifestyle they espouse.

Re: Soybean oil affects hypothalamus, causes genetic changes in mice: study (2020)

#70
post #36

I went all carnivore 15 months ago, and a side effect of that is the removal of all seed oils from the diet. The results include complete remission of my diabetes and associated fatigue and brain fog, the loss of more than 60 excess pounds, greater joy of life and emotional stability, and a new, regular desire to exercise and move my body. I don't know how much of that is about cutting out seed oils. I am getting lar…

Did you cut out carbs as well?
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