Hacker News Board Hacker News, browsed like a classic message board
Live data from Hacker News

Soybean oil affects hypothalamus, causes genetic changes in mice: study (2020)

universityofcalifornia.edu

Post reply on HN
Print view View original

41–50 of 464 posts

Re: Soybean oil affects hypothalamus, causes genetic changes in mice: study (2020)

#41

Post by The_rationalist »

cottager2 wrote: post #18
tpush wrote: post #9

In mice . Let's temper the usual nutritional conspiracy allegations and grand proclamations of effects on humans until someone trained and knowledgable provides an interpretation of this study. Most of these rodent studies end up not being applicable to humans anyway.

Do you have a source for the claim that most studies done in mice don’t hold up? As far as I know, mice are quite a good proxy, although there are some differences. It seems like it would be a complete waste of time to study mice if most results didn’t hold.

No post body was provided.

Re: Soybean oil affects hypothalamus, causes genetic changes in mice: study (2020)

#42

Post by dinero_rojo »

I kinda doubt there's a ton of overlap between "right wing" twitter and HN, but there's been a decent amount of hate on seed oils (especially soybean oil) over there lately. Here's one of the bigger accounts promoting it in case anyone here'd wanna glance at what those people might be saying: https://twitter.com/SeedOilDsrspctr

Re: Soybean oil affects hypothalamus, causes genetic changes in mice: study (2020)

#43

Post by KerryJones »

Another related source of information is The Big Fat Surprise by Nina Teicholz, Erin Bennett. It goes deep into pretty much every major nutritional study from 1950-2005 and shows a lot of how soybean and many other seed/vegetable oil was originally founded on poorly constructed studies and how there is likely much more harm from them.

Highly recommended. It lines up well with this article.

Re: Soybean oil affects hypothalamus, causes genetic changes in mice: study (2020)

#44

Post by telchior »

Taking account that this is unproven in humans -- it's enough for me to avoid soybean oil, as cooking oil choice is not very important for my palate.

That said, which oils would you use for frying and baking? Most high smoke point oils are, like soybean, polyunsaturated, so I'd guess that they could have some of the same (proposed) negative effects. Bonus points if the alternative is widely available (I see potential options like avocado oil and ghee, which may not be in my local stores).

Edit: To clarify, the following oils are ALSO very high in PUFAs and thus might have similar issues to soybean oil: grapeseed, safflower, sunflower, corn, walnut, cottonseed. Somewhat lower but still fairly high in PUFAs: sesame, canola, peanut. Finally, some oils are low in PUFAs but not suitable for the same uses as soybean oil. Olive oil is one of these.

Re: Soybean oil affects hypothalamus, causes genetic changes in mice: study (2020)

#45

Post by whalesalad »

adamgordonbell wrote: post #30

What products contain soybean oil? I use canola or olive oil, but not sure I've ever bought soybean oil. Is there any reason to think canola would be better?

No. Virtually all seed oils are terrible for you.

Re: Soybean oil affects hypothalamus, causes genetic changes in mice: study (2020)

#46

Post by politician »

adamgordonbell wrote: post #30

What products contain soybean oil? I use canola or olive oil, but not sure I've ever bought soybean oil. Is there any reason to think canola would be better?

Someone above said that it's usually marketed as "vegatable oil".

Re: Soybean oil affects hypothalamus, causes genetic changes in mice: study (2020)

#47

Post by zhte415 »

simonsarris wrote: post #4

> The same UC Riverside research team found in 2015 that soybean oil induces obesity, diabetes, insulin resistance, and fatty liver in mice. Then in a 2017 study, the same group learned that if soybean oil is engineered to be low in linoleic acid, it induces less obesity and insulin resistance. > “The hypothalamus regulates body weight via your metabolism, maintains body temperature, is critical for reproduction and…

The article specifically mentions, following that cited part, on Linoleic acid:

> the research team has not yet isolated which chemicals in the oil are responsible for the changes they found in the hypothalamus. But they have ruled out two candidates. It is not linoleic acid, since the modified oil also produced genetic disruptions; nor is it stigmasterol, a cholesterol-like chemical found naturally in soybean oil.

Re: Soybean oil affects hypothalamus, causes genetic changes in mice: study (2020)

#48

Post by zdragnar »

cottager2 wrote: post #18
tpush wrote: post #9

In mice . Let's temper the usual nutritional conspiracy allegations and grand proclamations of effects on humans until someone trained and knowledgable provides an interpretation of this study. Most of these rodent studies end up not being applicable to humans anyway.

Do you have a source for the claim that most studies done in mice don’t hold up? As far as I know, mice are quite a good proxy, although there are some differences. It seems like it would be a complete waste of time to study mice if most results didn’t hold.

The post itself includes a caution against applying this information directly to humans. It is a sign further research is warranted, nothing more (as opposed to completely pointless).

Re: Soybean oil affects hypothalamus, causes genetic changes in mice: study (2020)

#49

Post by mrob »

sinyug wrote: post #39
simonsarris wrote: post #4

> The same UC Riverside research team found in 2015 that soybean oil induces obesity, diabetes, insulin resistance, and fatty liver in mice. Then in a 2017 study, the same group learned that if soybean oil is engineered to be low in linoleic acid, it induces less obesity and insulin resistance. > “The hypothalamus regulates body weight via your metabolism, maintains body temperature, is critical for reproduction and…

> Soybean oil I saw this video about seed oils a few months back.[1] Some of the information there tracked stuff I have been reading for a while. Decided to switch over completely to coconut oil and ghee (clarified butter). A comment on the video that matches my view on the subject: > If you want to be healthy just do the exact opposite of everything we were told about nutrition by mainstream experts for decades [1]…

>ghee

Cholesterol oxides in Indian ghee: possible cause of unexplained high risk of atherosclerosis in Indian immigrant populations:

https://pubmed.ncbi.nlm.nih.gov/2887943/

"Substantial amounts of cholesterol oxides were found in ghee (12.3% of sterols), but not in fresh butter"

Re: Soybean oil affects hypothalamus, causes genetic changes in mice: study (2020)

#50

Post by shadowgovt »

> In all likelihood, it is not healthy for humans.

I'm sure their mouse studies are showing them something, but this is the kind of bold claim that wants to be tested anthropologically as much as bio-pharmacologically.

China is the leading consumer of soybean oil. It's been a dietary staple since the 11th century.

Any claim it's generally unhealthy has to reconcile with the fact that it's been used for 1000+ years. Perhaps one could claim "not optimally healthy," but it's not a novel chemical.

Post reply on HN