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Soybean oil affects hypothalamus, causes genetic changes in mice: study (2020)

universityofcalifornia.edu

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Re: Soybean oil affects hypothalamus, causes genetic changes in mice: study (2020)

#51

I'm not obese. I have a family history of obesity. On the contrary, I am a bit underweight, and I have tried very hard to gain weight and have never managed to accomplish much. What are obese people eating that I'm not eating? What foods are high in soybean oil?

Have you ever kept a log of the food you eat in a day? Admittedly I come at this from a very different perspective being obese, and having been much more obese in the past, but actively logging my food and retrospectively calculating calories gave me a much better sense of how much I was actually eating.

When you've recorded some data on that it would be productive to calculate your basal metabolic rate, which are the calories your body uses on the daily (so any exercise adds on to that). Comparing those two figures might be productive.

Of course there may be genetic factors going on but perception is so powerful it's the first thing I'd question

Re: Soybean oil affects hypothalamus, causes genetic changes in mice: study (2020)

#52

What products contain soybean oil? I use canola or olive oil, but not sure I've ever bought soybean oil. Is there any reason to think canola would be better?

"Vegetable oil" seems to usually be all or mostly soy bean oil. I believe margarine is also made largely from soy, as well.

Re: Soybean oil affects hypothalamus, causes genetic changes in mice: study (2020)

#53
post #9

In mice . Let's temper the usual nutritional conspiracy allegations and grand proclamations of effects on humans until someone trained and knowledgable provides an interpretation of this study. Most of these rodent studies end up not being applicable to humans anyway.

Do you have a source for the claim that most studies done in mice don’t hold up? As far as I know, mice are quite a good proxy, although there are some differences. It seems like it would be a complete waste of time to study mice if most results didn’t hold.

Mice strike the best balance for science of animals who are decent proxies for humans, are inexpensive to breed and genetically manipulate, and who don't trigger much ethical backlash.

It seems to me though that the extent to which mouse biology and behavior translates well to human biology and behavior might also be the extent to which it's totally immoral. "Yes, but think of how many future lives I'll save by vivisecting this sentient or semi-sentient being..."

Re: Soybean oil affects hypothalamus, causes genetic changes in mice: study (2020)

#54
post #9

In mice . Let's temper the usual nutritional conspiracy allegations and grand proclamations of effects on humans until someone trained and knowledgable provides an interpretation of this study. Most of these rodent studies end up not being applicable to humans anyway.

There is plenty of research done on the harmful effects of seed oils.

It’s not a stretch to assume this is yet another study demonstrating this in mice models.

Re: Soybean oil affects hypothalamus, causes genetic changes in mice: study (2020)

#55
Interestingly enough, soybean oil is virtually non-existent over here in Germany - at least not as oil that you can buy (here the dominant ones are canola, good ol' sunflower and olive - the latter not for frying though), and I also haven't heard of it as an ingredient in industrial foods, but I wouldn't vouch for that.

Re: Soybean oil affects hypothalamus, causes genetic changes in mice: study (2020)

#56
post #47

> The same UC Riverside research team found in 2015 that soybean oil induces obesity, diabetes, insulin resistance, and fatty liver in mice. Then in a 2017 study, the same group learned that if soybean oil is engineered to be low in linoleic acid, it induces less obesity and insulin resistance. > “The hypothalamus regulates body weight via your metabolism, maintains body temperature, is critical for reproduction and…

The article specifically mentions, following that cited part, on Linoleic acid: > the research team has not yet isolated which chemicals in the oil are responsible for the changes they found in the hypothalamus. But they have ruled out two candidates. It is not linoleic acid, since the modified oil also produced genetic disruptions; nor is it stigmasterol, a cholesterol-like chemical found naturally in soybean oil.

It explains why they chose coconut oil for the comparison, it has one of the least amounts of linoleic acid in its composition in any fat.

Ironically, lineseed oil is also low in linoleic acid.

https://www.news-medical.net/health/Oils-Rich-in-Linoleic-Ac...

Re: Soybean oil affects hypothalamus, causes genetic changes in mice: study (2020)

#57

My understanding is that most of the oils we use are unhealthy. They are highly processed and inflammatory. The good oils are avocado oil, extra virgin olive oil and coconut oil. Is this correct?

Yes afaik, although I’ve heard some ppl say that coconut oil has too much saturated fat making it not great for you.

Avocado oil seems to be the best?

Re: Soybean oil affects hypothalamus, causes genetic changes in mice: study (2020)

#59

My understanding is that most of the oils we use are unhealthy. They are highly processed and inflammatory. The good oils are avocado oil, extra virgin olive oil and coconut oil. Is this correct?

avocado might not be so trustworthy, see:

https://news.ycombinator.com/item?id=30105062

ghee is a great alternative IMO.

Re: Soybean oil affects hypothalamus, causes genetic changes in mice: study (2020)

#60

Taking account that this is unproven in humans -- it's enough for me to avoid soybean oil, as cooking oil choice is not very important for my palate. That said, which oils would you use for frying and baking? Most high smoke point oils are, like soybean, polyunsaturated, so I'd guess that they could have some of the same (proposed) negative effects. Bonus points if the alternative is widely available (I see potential…

Humanity has been using Olive Oil for at least 1000 years. So that seems pretty safe to me.
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