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Marijuana accelerates growth of HPV-related head and neck cancer (2020)

health.ucsd.edu

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Re: Marijuana accelerates growth of HPV-related head and neck cancer (2020)

#121

Post by trasz »

mensetmanusman wrote: post #110
pengaru wrote: post #24

Earlier quoted context omitted.

Children of such people have been dealt an awful hand.

If only life were simple enough to make such statements. On the facet of risk towards a particular form of cancer, it might be an awful hand. On the fact of mental health, it might be a better hand than others: https://www.hsph.harvard.edu/news/press-releases/religious-u... At the moment, since mental health seems to be a bigger issue than cancer (according to the media), it’s not trivial to define what an awful hand…

Your article is about religiousness in general, while the problem with HPV prevention is specific to a few specific denominations.

Re: Marijuana accelerates growth of HPV-related head and neck cancer (2020)

#122

Post by quickthrowman »

jjtheblunt wrote: post #31
asdfasgasdgasdg wrote: post #27

Earlier quoted context omitted.

Gardasil 9 hits enough of the HPV variants that the rate of cancer-causing HPV infections has fallen by 90% in the US. And that's with the fraction of folks who are anti-vaxxers taken into account. This is one of those diseases where the means to prevent being infected is already in hand.

Why do they only offer it to teens (in the US , from what I've seen)?

When you start having sex you’ll likely be exposed to the virus. Once you have been exposed, the vaccine doesn’t do you any good. The number of people in an age cohort that haven’t had sex rapidly approaches 0 as that cohort ages into adulthood. Therefore, it is almost entirely offered to teens to try and vaccinate before they’re naturally exposed.

Re: Marijuana accelerates growth of HPV-related head and neck cancer (2020)

#123

Post by selimthegrim »

intricatedetail wrote: post #87
avs733 wrote: post #86

Earlier quoted context omitted.

“ Cannabinoids Promote Progression of HPV-Positive Head and Neck Squamous Cell Carcinoma via p38 MAPK Activation” That is the study name. You are referencing the title of the press release from the university they work at. While it’s perfectly fair to discuss the historical context of words, it’s important that we also recognize that using commonly used terminology in translating science for public consumption is nec…

The N word is also commonly used, doesn't mean it's right. There should be no place for racism in academia. I am surprised this is up since 2020.

What do you think Spanish speakers call it?

Re: Marijuana accelerates growth of HPV-related head and neck cancer (2020)

#124

Post by BeFlatXIII »

SuoDuanDao wrote: post #104
Hnrobert42 wrote: post #101

Earlier quoted context omitted.

I thought folks often smoke marijuana to cope with nausea induced by chemo therapy. That might be part of the “crisis” aspect.

Given that caloric restriction makes chemo therapy more effective[1], I wonder whether the mechanism is as simple as people who smoke cannabis during treatment having more appetite, which lowers the effectiveness of the treatment. [1] https://link.springer.com/article/10.1186/s12916-017-0873-x

Fatal cases of the munchies.

Re: Marijuana accelerates growth of HPV-related head and neck cancer (2020)

#125

Post by quickthrowman »

xqcgrek2 wrote: post #2

Cannabis seems like it isn't all its hyped up to be -- and the $MJ cannabis ETF is down 70% since its 2019 peak.

The stocks were overvalued by idiots who don’t understand cannabis is a commodity that is extremely easy to grow, with virtually zero barriers to entry. Canada has or had a massive surplus of cannabis.

Black market weed is expensive because every step in the chain adds a risk premium to account for the legal risk of possessing and selling cannabis (and the physical risk of being robbed, etc). If it’s legal, that risk premium evaporates and the price (and profit margin) goes way down.

Re: Marijuana accelerates growth of HPV-related head and neck cancer (2020)

#126

Post by ChefboyOG »

mensetmanusman wrote: post #110
pengaru wrote: post #24

Earlier quoted context omitted.

Children of such people have been dealt an awful hand.

If only life were simple enough to make such statements. On the facet of risk towards a particular form of cancer, it might be an awful hand. On the fact of mental health, it might be a better hand than others: https://www.hsph.harvard.edu/news/press-releases/religious-u... At the moment, since mental health seems to be a bigger issue than cancer (according to the media), it’s not trivial to define what an awful hand…

That "(according to the media)" bit of hand-waving is doing a lot of work.

Re: Marijuana accelerates growth of HPV-related head and neck cancer (2020)

#127

Post by ChrisLomont »

buescher wrote: post #114
ChrisLomont wrote: post #95

Earlier quoted context omitted.

That study has been debunked. For example, in it he guesses at some factors fundamental to his thesis. Later studies to empirically measure those factors found his guesses to be wildly incorrect, and correcting for the empirical data, Ioannis claims are found to be unsupportable.

A fair criticism of Ionnidis would be "statisticians always knew this about every field that reports statistical significance with p-values, but no one was going to listen, I don't know what that guy's got". I'm not aware of any substantive "debunking" of his famous paper, which is not a "study".

You are correct - it was not a study, since that would require studying some empirical data instead of making up values. It was actually an essay, akin to a guest blog post, but for a journal [0].

Look at his paper - it clearly relies on values that he made up - there is not a single measurement of actual papers to fill in his formulas.

What he did was show it was possible for stuff to be wrong, given values he pulled out the air. When people did studies to measure those values from real papers, which Ioannidis did not, they found his made up values far from reality. For example, this paper shows how to do actual measurements of the values Ioannidis made up [1].

Here's one [2] (of many) paper showing that Ioannidis did not prove the claim people think he did for other reasons.

Carefully read the actual original paper, and note that there are many values to input to his model, that he hand waves over and does not actually measure.

[0] https://journals.plos.org/plosmedicine/article?id=10.1371/jo...

[1] https://arxiv.org/ftp/arxiv/papers/1301/1301.3718.pdf

[2] https://econpapers.repec.org/article/plopmed00/0040168.htm

Re: Marijuana accelerates growth of HPV-related head and neck cancer (2020)

#128

Post by ChrisLomont »

throwanem wrote: post #111
ChrisLomont wrote: post #95

Earlier quoted context omitted.

That study has been debunked. For example, in it he guesses at some factors fundamental to his thesis. Later studies to empirically measure those factors found his guesses to be wildly incorrect, and correcting for the empirical data, Ioannis claims are found to be unsupportable.

Debunked where, by whom? Not that Ioannidis isn't a publicity hound of the first water, but if nothing else it'd be useful to have cites for the next time this comes up.

I posted 2 citations in this thread. Or simply read his paper, and you can see how it doesn't prove without fail what it claims - it relies on numbers he made up - later groups measured these numbers and found the made up ones invalid.

Re: Marijuana accelerates growth of HPV-related head and neck cancer (2020)

#129

Post by Terry_Roll »

selimthegrim wrote: post #120
Terry_Roll wrote: post #78

Earlier quoted context omitted.

You might want to ask your medical expert about this. Penicillin based anti biotics break down into penicillamine https://wikidiff.com/penicillin/penicillamine "penicillamine treatment relies on its binding to accumulated copper and elimination through urine." https://en.wikipedia.org/wiki/Penicillamine "Copper deficiency reduces interleukin-2 (IL-2) production and IL-2 mRNA in human T-lymphocytes" https://pubmed.ncb…

Wouldn’t you want to stay copper depleted? I don’t follow.

Copper depleted for what?

Re: Marijuana accelerates growth of HPV-related head and neck cancer (2020)

#130

Post by Terry_Roll »

refurb wrote: post #93
Terry_Roll wrote: post #82

Earlier quoted context omitted.

L-cysteine, glycine, and L-glutamate

How does glycine release glutathione? And from where ?

https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2696075/ "This review is the introduction to a special issue concerning, glutathione (GSH), the most abundant low molecular weight thiol compound synthesized in cells."
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