I mean... you probably shouldn't ignore the thing that kills the most people, to deal with something that kills less people than that. And yes, we basically do the calculation (deaths vs convenience) all the time.. look at speed limits for cars, they're just a calculation of traffic deaths per year vs time losses due to lower speed limits.. a few deaths is ok, because everyone can get to work faster, but a lot of deaths is not ok.
Especially now, with vaccines... if someone doesn't want to vaccinate, who exactly are they endangering (except others, who also chose not to vaccinate)? Thinking the vaccinated won't get in contact with omicron from other vaccinated people who got infected is stupid, but we still don't let unvaccinated people go to the bar, while I can go there, even infected (and with omicron, i could be infected right now, but noone tests us, the vaccinated ones).