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Experimental depression treatment is nearly 80% effective in controlled study
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Re: Experimental depression treatment is nearly 80% effective in controlled study
#292Earlier quoted context omitted.
Where "someone" is a therapist or counsellor. They can refer you on to someone who works with pharmaceuticals if necessary, but there's a lot to try before going that route.
Heads up, ‘There is a lot to try before going that route’ is a medical opinion that is hard to notice. Exactly what the treatment plan would be and in what order is entirely up to the doctor and sometimes (often) the best thing that works is the actual drugs. I’m just conscious of this because I’ve seen this argument used to justify delaying actual treatment in favour of ‘alternative medicine’.
True, yes, but nothing you hear in a CBT session should be super surprising. It may help you see things in a new way or understand the motivations of the other people involved in your life situations, but they're not going to tell you sleep with crystals or wear a magnetic bracelet or something.
Basically the counselling/therapy part of the process would be identifying if there's a "real world" root cause to address ahead of going the pharma route and facing potential side effects, and/or the reality of having to go off it later and immediately regressing because the root cause hasn't been fixed.
In any case, I'm obviously not a doctor; neither this post nor the GP should be construed as medical advice.
Re: Experimental depression treatment is nearly 80% effective in controlled study
#293Earlier quoted context omitted.
Just start the process, get the fMRI scan, pay for that, and request a copy and bail.
For those taking this seriously: fMRI requires careful presentation of stimuli and a complex analysis. It’s not just a scan. I doubt you can get that at Scans’R’Us.
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Re: Experimental depression treatment is nearly 80% effective in controlled study
#294Earlier quoted context omitted.
There are a few psychological constructs in our head that really tie deep into the mental pain I forgot who i saw recently that said we have a strong mirroring need in our brain, which means our happiness is extremely relative, if you suffer while people don't .. it hurts more; if people are in the same boat the pain gets softer. Oh and yeah unconscious fears are often the root of so many mental issues.. abandoning (…
> There are a few psychological constructs in our head that really tie deep into the mental pain Indeed, one of those is the 'chemical imbalance' theory of depression, which in itself can lead to a person believing there is no hope because they just are a bag of chemicals. The way out of this particular conundrum is as the OP stated - therapy which addresses the cause of the imbalance, which has every indication of b…
> which in itself can lead to a person believing there is no hope because they just are a bag of chemicals.
I'd expect the opposite effect. If we are bags of chemicals, we can change ourselves by altering the composition of chemicals. The hard part is finding the proper balance.
Re: Experimental depression treatment is nearly 80% effective in controlled study
#295While depression can certainly be caused by chemical imbalance and not because of how your unconscious mind impacts/limits your experience of life, I took the approach that exploring my subconscious through therapy was the way to get out. For me it worked very well and I think the journey is an amazing one to go on. Building from the ground up and understanding all the foundations within. I always wonder about treatm…
I think the main problem we view depression as a disease when it is a symptom with several possible causes. Most people I know haven't done the deep introspection when life circumstances or past in some cases preverbal traumas exist. Additionally, we're generally told quite a lot of lies and made to believe fantasies from the earliest ages about - the world, who we are, and our place in the world. I have a theory and…
> I think the main problem we view depression as a disease when it is a symptom with several possible causes.
I agree. The fact that depression and mental illnesses highly correlate with lack of religion and rise of the secular nation is something that should be investigated more.
Re: Experimental depression treatment is nearly 80% effective in controlled study
#296Earlier quoted context omitted.
Sorry you had to endure this. It's true that adult life is wide and chaotic and you can slowly end up in a black hole situation. A bed room theory is live small and grow through tiny risks. Small means your life is easier to secure and you can try stuff and fallback as soon as something goes wrong. It's only a theory, that came up through the realization that a lot of pain comes from bad obligations. Too much mortgag…
Thanks, very thoughtful of you. I was saying almost the same thing as your last line to a colleague, taking many responsibilities in parallel before waiting for full closure, can lead to failing something that you would normally be able to do, just because you were stressed out by the other things you had to do in parallel.
what I found hard is:
- being able to recognize what are too large obligations, with time your nose becomes better at avoiding them quick
- being able to recognize how much I want to bear
- learning to say no thanks
Re: Experimental depression treatment is nearly 80% effective in controlled study
#297So the controls got a sham TMS, but not a control location?
Wouldn’t it be risky to perform TCMS in a region unknown in impacts of TCMS?
Probably although based on my understanding maybe not as risky as it might seem based on what's been done. I agree it's an issue and I don't mean to minimize it, but at the same time there's good evidence location is much more fuzzy than it seems. At some level it's nontrivial because it has implications for actual causal mechanisms.
Re: Experimental depression treatment is nearly 80% effective in controlled study
#298Case size 14, control size 15. It's 2021; you shouldn't be able to publish a psychology result with statistics this weak.
That’s an aggressive take for someone who hasn’t bothered to consider the effect size when claiming to know statistics better than these authors.
Re: Experimental depression treatment is nearly 80% effective in controlled study
#299Earlier quoted context omitted.
Yeah, this is a fairly standard size for an early trial. Trials cost money. Even if this is a lucky outlier and it turns out to be no better than the placebo in a larger trial, having a decently strong positive result can hugely improve your chances of getting the money (and interest) needed to run a larger trial.
But it’s worth realizing this small of a trial size likely means there’s a long road to widespread use
Sure, but at that point the complaint is in either the journalism being misleading (implying it's "coming soon" in a layman's use of "coming soon"), or our outsider view into internal messaging is misunderstanding the claims (if this was written for people familiar with the field, "there's a long way to go" is safe to assume as base knowledge, which outsiders may not have).
tl;dr yeah, but everyone knows that / science journalism is terrible.
Re: Experimental depression treatment is nearly 80% effective in controlled study
#300Earlier quoted context omitted.
I've had depression for 20+ years and the best way I would describe it is like this: Think of that little "kick" you get when you think of something you want to do. Maybe you like eating ice cream, maybe you like playing tennis, whatever it is... that feeling, that subconscious little mental boost that gets you up off your ass, and moving... is completely absent in the depressed mind. That spark that initiates and su…
Does that apply to things you 'have' to do as well? I don't really like shopping for groceries, but I'd rather do that, than order take out that's expensive and probably not very healthy. If I'm going to cook something, I'd rather cook something with a different taste than eat pasta again. I don't really want to do laundry, but I do want to have clean clothes that don't smell. If I could afford to do so I wouldn't wo…
Yes.
I am the same way. My depression isn’t severe enough that I CANT do the things that need to be done, but rather, they take immense effort and personal discipline.
Of course everyone (even non depressed people) sometimes struggle to do things they have to do, but don’t want to do. It’s all about how severe that struggle is, not whether or not that struggle exists at all.