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Experimental depression treatment is nearly 80% effective in controlled study

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Re: Experimental depression treatment is nearly 80% effective in controlled study

#231

Earlier quoted context omitted.

There are a few psychological constructs in our head that really tie deep into the mental pain I forgot who i saw recently that said we have a strong mirroring need in our brain, which means our happiness is extremely relative, if you suffer while people don't .. it hurts more; if people are in the same boat the pain gets softer. Oh and yeah unconscious fears are often the root of so many mental issues.. abandoning (…

I'm not sure what you mean when you say abandon (to) fears. But my experience was that when I could pinpoint the fear, overcoming it by facing it was the way out. Often as infants we develop legitimate fears in the context of our vulnerable position and extreme dependency on maintaining the parental relationship. These fears made sense then and helped us keep our parents calm, but interrupt our adult lives. These fea…

Curiosity: what if you've done so and your fears have been reinforced instead?

Background: after a difficult childhood, I did a therapy, discovered self improvement and lived a few years where I faced fears regularly and expanded massively. However, multiple debatable decisions built up to a point where everything broke down. Lost my job, hoped on 3 jobs even worse afterwards, was morally harassed, and the resulting bad mood and general negativity made me lose friends, and be even more vulnerable. Loss of confidence made me sabotage more or less voluntarily other aspects of my health, balance and projects. Therapists, SSRI, etc. no way to get out of it (just lots of money taken away => even more pressure/problems). It felt like death since I had to go through these many years, helpless, hopeless. It was worth than any experience in my childhood, and still traumatizing.

Now, the absence of "death" at an instant t when doing a "dangerous" action doesn't mean that death can't come later as a consequence (ex. tell your opinion at work -> doesn't kill you but if it leads to be fired later and start a cycle like above, it can be dangerous). Therefore there's never validation that my actions don't kill, they're just written on a list, with consequences pending, and the fear of the ultimate judgment is impossible to confront, unless it all happens again and this time I manage it. How would you confront this kind of fears?

Re: Experimental depression treatment is nearly 80% effective in controlled study

#232

Earlier quoted context omitted.

There are a few psychological constructs in our head that really tie deep into the mental pain I forgot who i saw recently that said we have a strong mirroring need in our brain, which means our happiness is extremely relative, if you suffer while people don't .. it hurts more; if people are in the same boat the pain gets softer. Oh and yeah unconscious fears are often the root of so many mental issues.. abandoning (…

> There are a few psychological constructs in our head that really tie deep into the mental pain Indeed, one of those is the 'chemical imbalance' theory of depression, which in itself can lead to a person believing there is no hope because they just are a bag of chemicals. The way out of this particular conundrum is as the OP stated - therapy which addresses the cause of the imbalance, which has every indication of b…

So, what type of therapy should one seek out if they get severe depression for a week or so every month, always during their period?

If the "theory" that depression can be caused by chemical or hormonal imbalances is wrong, then what externality is causing such severe depressive swings on such a regular basis, like clockwork?

What "mindset" should a pregnant mother with a history of post partum depression put herself in so that she doesn't feel depressed even after everything goes great and she has a perfect baby and all the support she needs?

Re: Experimental depression treatment is nearly 80% effective in controlled study

#233
post #231

Earlier quoted context omitted.

I'm not sure what you mean when you say abandon (to) fears. But my experience was that when I could pinpoint the fear, overcoming it by facing it was the way out. Often as infants we develop legitimate fears in the context of our vulnerable position and extreme dependency on maintaining the parental relationship. These fears made sense then and helped us keep our parents calm, but interrupt our adult lives. These fea…

Curiosity: what if you've done so and your fears have been reinforced instead? Background: after a difficult childhood, I did a therapy, discovered self improvement and lived a few years where I faced fears regularly and expanded massively. However, multiple debatable decisions built up to a point where everything broke down. Lost my job, hoped on 3 jobs even worse afterwards, was morally harassed, and the resulting…

Sorry you had to endure this. It's true that adult life is wide and chaotic and you can slowly end up in a black hole situation.

A bed room theory is live small and grow through tiny risks. Small means your life is easier to secure and you can try stuff and fallback as soon as something goes wrong.

It's only a theory, that came up through the realization that a lot of pain comes from bad obligations. Too much mortgage, obligation to stay in a toxic job. Also contexts too large to really know if what you can do or not (such as politics at work).

Re: Experimental depression treatment is nearly 80% effective in controlled study

#234
post #146

Earlier quoted context omitted.

Does that apply to things you 'have' to do as well? I don't really like shopping for groceries, but I'd rather do that, than order take out that's expensive and probably not very healthy. If I'm going to cook something, I'd rather cook something with a different taste than eat pasta again. I don't really want to do laundry, but I do want to have clean clothes that don't smell. If I could afford to do so I wouldn't wo…

Does that apply to things you 'have' to do as well? For some folks: This is the reason for a shower becoming a monumental victory in one's day: Sometimes just getting out of bed is a struggle for folks. I'm in a few cooking subreddits, and often get folks looking for "depression food": Food that takes no effort (cooking at all can be too much effort) yet is still a bit healthy. At this point, you probably aren't enjo…

I have seen a person so depressed they didn't even care to get out of bed to have a bowel movement. They just stayed there in it until someone else came to clean it all up.

Re: Experimental depression treatment is nearly 80% effective in controlled study

#235
post #57

“I don’t procrastinate anymore,” he added. “I’m sleeping better. I completely quit alcohol. I’m walking my dog and playing the guitar again, for nothing more than the sheer joy of it.” Most importantly, he said, “I’m remaining positive and being respectful of others. These are big changes in my life.” Serious question: are these typical signs of depression? Now I'm wondering if I have depression.

I've had depression for 20+ years and the best way I would describe it is like this: Think of that little "kick" you get when you think of something you want to do. Maybe you like eating ice cream, maybe you like playing tennis, whatever it is... that feeling, that subconscious little mental boost that gets you up off your ass, and moving... is completely absent in the depressed mind. That spark that initiates and su…

This. And also a gazillion other things.

Years ago I was recommended a book written by a Dutch psychiatrist who had developed depression himself. The tagline was sort of "here's a professional who suffers from it, this will be insightful."

I couldn't relate to his condition for one iota (let alone finish the book); as he had mostly feelings of guilt and shame, and dark, weird mental images.

I guess depression is a sort of blanket term by now for many things, which probably complicates diagnosis and most of all, treatment.

Plus, I recently discovered the term "sh*t life syndrome", which is apparently getting to be known as a well-known term in the US/UK psychiatrics system (at least it has a Wikipedia page claiming that). It describes people who are poor or lonely because of the system surrounding them (prime example: they live in an area with raging unemployment). In that case, it's argued, symptoms of depression might actually be the logical response to an outside stimulus (or lack thereof). Yet, it appears many of these people are referred to psychological treatment because, well, society doesn't come up with any better option.

But what rubicon33 describes is certainly one way of depression, and I think a common one. But I'd go one step further even: Yes, people lack that little "kick" to get them going and do something entirely. But I don't think that's the root cause.

The root cause, to me, is that this kick has been subconciously "unlearned". Because when people with this sort of depression DO force themselves to do some of these things (and man, do they need to force themselves, with rational arguments and all sorts of tricks), they are not enjoying it. To stick with the example of playing tennis: Non-depressed people come back and say: "That was fun! I powered myself out on the tennis court, maybe I even won, I feel good.". People with this particular sort of depression come back and say: "That was physically, but mostly mentally exhausting. I want to sleep or procrastinate now and reset my thoughts to the baseline of being emotionless."

Disclaimer: Yes, I think I can also kind of speak on this subject. I've been repeatedly diagnosed with childhood PTSD and depression possibly ever since that (which makes it 30+ years); which doesn't mean that I'm not questioning this all the time, because the biggest trick played by depression is to make you think that everything may be just normal sadness/exhaustion/"not trying hard enough" ...).

Re: Experimental depression treatment is nearly 80% effective in controlled study

#236
post #158
post #82

Earlier quoted context omitted.

Noticed that both you and the OP mentioned drinking. Just the drinking can cause much of this. Drinking screws up your sleep cycle, which can also cause much of this. Drinking sessions are also time consuming, so you have less time for other things you enjoy anyway. Sure, some things you can do while drinking, but those may not be the things you would prefer to be doing while sober.

Sure! Though I drink basically not at all when I’m not in a depressive episode. It’s more of a subconscious “self medication” thing, and the symptoms don’t subside even if I’m not drinking sadly.

Seems like a stimulant might be a more logical self medication for depression than a depressant.

Re: Experimental depression treatment is nearly 80% effective in controlled study

#237
post #194

Earlier quoted context omitted.

Buproprion is quite good at removing false reward loops. Made me really tone down video games. It's used also for smoking cessation. It's quite subtle. The other SSRI/SNRI meds have strong side-effects. I will say that the effect is permanent. It's rewiring your brain when you use it. If it's helping you to spend some time on harder but more important self-improvement, then great. If not, you should consider switchin…

which ADHD medicine is good these days? do they raise blood pressure or act as a stimulant? (I guess I'm asking if there's anything better than adderall and ritalin these days)

Yes, there are much better options like Vyvanse or extended release Adderall or Concerta.

Re: Experimental depression treatment is nearly 80% effective in controlled study

#239

Earlier quoted context omitted.

as someone with mental health issues going through a rather prolonged and winding down period, i’ve taken this before. just got my high score! going to bring this up with my therapist tomorrow

I am increasingly confident I suffer from depression, rather than just being generically miserable. How do you deal with the trust issues posed by that questionnaire? I have suicidal thoughts most days, but I'm concerned that revealing this to an NHS doctor would quickly result in my freedom of choice on what happens next being taken from me. Seems like one of the few cases where US healthcare (where you are explicit…

Involuntary admission works the same way in the US.

I have kinda the same problem. I've had depression for a very long time - stable, but consistently declining. I get the "... or I could just kill myself" xapata mentioned a couple times per week and the reasons I don't are basically "that sounds like work" and "that would make my mother sad". Which aren't exactly good reasons, I know, but so far I've done very little actual self-harm and I very much don't want to get involuntarily admitted. I really would like to get help to deal with depression. I've battled it out alone with it for 15+ years and I'm not exactly winning that fight. But- anyone that's qualified to offer that help is pretty much legally required to admit me if I answer their screening questions somewhat truthfully.

Damned if you do, damned if you don't.

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