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Experimental depression treatment is nearly 80% effective in controlled study

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Re: Experimental depression treatment is nearly 80% effective in controlled study

#101
post #76

Huh, I've been talking to my therapist about my antidepressants not being terribly effective anymore. Is there a way to sign up for a clinical trial for this?

Or you could look into psychedelic medicine. On the legal side, ketamine has helped a lot of people with treatment resistant depression. You could also look into participating in clinical trials of MDMA or psilocybin. The clinical trial results for those medicines are phenomenal, too.

Re: Experimental depression treatment is nearly 80% effective in controlled study

#102
post #82
post #59

Earlier quoted context omitted.

Anecdotally, the lack of those things are definitely present in myself when I'm experiencing a depressive episode (I am diagnosed with clinical depression): I sleep badly, either not at all or for 12-18 hours a day, I drink far too much, I do not leave my house, and my hobbies either fall by the wayside entirely or I partake in them with no enjoyment or happiness from it. If you're experiencing those, it might be wor…

Noticed that both you and the OP mentioned drinking. Just the drinking can cause much of this. Drinking screws up your sleep cycle, which can also cause much of this. Drinking sessions are also time consuming, so you have less time for other things you enjoy anyway. Sure, some things you can do while drinking, but those may not be the things you would prefer to be doing while sober.

[deleted]

Re: Experimental depression treatment is nearly 80% effective in controlled study

#104
post #82
post #59

Earlier quoted context omitted.

Anecdotally, the lack of those things are definitely present in myself when I'm experiencing a depressive episode (I am diagnosed with clinical depression): I sleep badly, either not at all or for 12-18 hours a day, I drink far too much, I do not leave my house, and my hobbies either fall by the wayside entirely or I partake in them with no enjoyment or happiness from it. If you're experiencing those, it might be wor…

Noticed that both you and the OP mentioned drinking. Just the drinking can cause much of this. Drinking screws up your sleep cycle, which can also cause much of this. Drinking sessions are also time consuming, so you have less time for other things you enjoy anyway. Sure, some things you can do while drinking, but those may not be the things you would prefer to be doing while sober.

These effects fit serious online gaming pretty accurately too.

Screws up your sleep cycle, is time consuming, causes you to not leave the house, makes other hobbies fall by the wayside.

Re: Experimental depression treatment is nearly 80% effective in controlled study

#105
post #94

Earlier quoted context omitted.

Do you have the same feelings about radiation therapy for cancer?

No, it's a very different situation since radiation therapy has such a long history at this point. I'm just not sure what the margin for error is, the failure modes for this magnetic therapy, or what makes a good magnetic therapist. Not a reason to stop developing it though.

Magnetic treatment has a long history... we've given billions of MRIs, no one's grown a 3rd arm.

Re: Experimental depression treatment is nearly 80% effective in controlled study

#106

I'm curious what this treatment would do to people who are "not depressed." What's the downside?

Perhaps the next Timothy Leary will have an fMRI in the basement and a line of customers running down the street.

Re: Experimental depression treatment is nearly 80% effective in controlled study

#107

Earlier quoted context omitted.

Yeah I know - it's a vicious cycle. I meant in cases where the depression trigger was an event like a death in the family, but where the person managed to keep it together despite their depression. In those fortunate cases, the only problem that needs solving is the person being "stuck" on a trauma - not a self perpetuating cycle.

What you're describing sounds more like grief than depression. While the profound sadness that comes from loss can certainly manifest itself in ways that seem like depression, they are not the same thing.

Grief can certainly morph into depression.

Re: Experimental depression treatment is nearly 80% effective in controlled study

#108
Hey! I didn't under go SAINT TMS specifically, but I have undergone TMS therapy. Reading this article I'm not sure how different what I received actually is compared to SAINT, but TMS absolutely changed my life. I was referred to TMS after a rash of different medications and years of talk therapy fell short on relieving the worst of my symptoms. Many of the benefits the patients in this article discuss are ones I received as well. I really do suggest it to anyone who is able to access it and suffers with severe depression.

Re: Experimental depression treatment is nearly 80% effective in controlled study

#109
post #76

Huh, I've been talking to my therapist about my antidepressants not being terribly effective anymore. Is there a way to sign up for a clinical trial for this?

Or you could look into psychedelic medicine. On the legal side, ketamine has helped a lot of people with treatment resistant depression. You could also look into participating in clinical trials of MDMA or psilocybin. The clinical trial results for those medicines are phenomenal, too.

Ketamine is ~70% effective at treating depression.

https://www.yalemedicine.org/news/ketamine-depression

Re: Experimental depression treatment is nearly 80% effective in controlled study

#110
post #88

I wonder what the underlying mechanism is. With the prevalence of magnetic fields in everyday life, I wonder if these could be affecting people negatively from prolonged exposure at lower doses or frequency.

"Fuckin' magnets, how do they work?"
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