Japanese scientists develop vaccine to eliminate cells behind aging

Post by kingcharles » Wed, Dec 15, 2021, 1:46 AM UTC

Synaesthesia wrote: post #238

obblekk wrote: post #194

1. Removing senescent cells extends life by 30-40% with huge quality of life improvements in the last 25% of the life (relative to control), in mice. This isn't an elimination of all aging, but quite a valuable thing regardless. Eventually, other causes of aging would kick in and still cause death, without a single senescent cell in your body (e.g. DNA methylation). 2. I believe all governments should create Warpspee…

Maybe instead of maximising GDP we should maximise happiness and there's plenty of low hanging fruit. I mean people are still starving to death and dying of preventable diseases...

Do we want peak happiness, though?

Almost all advances of civilisation are created through unhappiness about something. Would a state of total happiness stop creativity?

Post by derefr » Fri, Dec 17, 2021, 6:31 PM UTC

majkinetor wrote: post #156

derefr wrote: post #117

Earlier quoted context omitted.

> Its almost impossible to find out what happens after long time, say a decade, with the current approach. Most vaccines are much older than a decade. We know who gets vaccines; it's in their medical record, if not centralized anywhere. Longitudinal studies aren't impossible. So any random hospital could do a longitudinal retrospective data-collection study on the consequences for their own patients of either having…

> study on the consequences for their own patients of either having received a given vaccination decades previous or not, no? No! If you think its possible to pin point exactly what is the source of the problem with decade of various stressors piling up on anybody you should think again. It basically has infinite confounding variables. > those few poisoned bottles of aspirin did anything to increase the non-contingen…

> It basically has infinite confounding variables.

Yes, but: Law of Large Numbers. The great thing about retrospective data-collection studies is that you can potentially get hundreds of thousands of histories as datapoints. With those numbers, basically every confounder washes away, other than the selection effect of "what kind of person frequents this hospital rather than some other hospital." And you can get rid of that confounder, too, if you meta-analyze studies done in hospitals in very different areas.

Re: Japanese scientists develop vaccine to eliminate cells behind aging

Re: Japanese scientists develop vaccine to eliminate cells behind aging