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Japanese scientists develop vaccine to eliminate cells behind aging

japantimes.co.jp

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Re: Japanese scientists develop vaccine to eliminate cells behind aging

#151

Post by pas »

tux3 wrote: post #110
mmastrac wrote: post #87

Earlier quoted context omitted.

Is there a good resource to learn more about this without a Biology degree? I always assumed the body generated matching snippets at random and the law of large numbers would result in a match eventually.

>Is there a good resource to learn more about this without a Biology degree? Immunology is complicated . Some people call it the second most complicated system, behind the human brain. Someone else has mentioned the Kurzgesagt resources, which are great. If you want something more formal, OME is also a great resource I think. https://onlinemeded.org/spa/immunology >I always assumed the body generated matching snippet…

Do we know how exactly this happens? How fast this process "converges"? How big is the search space and how fast new candidates are generated?

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#152

Post by mlyle »

NullPrefix wrote: post #109
DeWilde wrote: post #36

Earlier quoted context omitted.

I have a rare condition related to insulin resistance and diabetes, blood sugar spikes greatly worsen my health. Discovered that vaccines spike sugar prety significantly after getting my two shots this year. Won't be getting boosters anytime soon as the side effects were gruesome.

Wouldn't that make you an antivaxxer? You surely don't want to be mixed up with that crowd, do you?

If someone has a demonstrated reaction to the vaccine -- e.g. much worse blood sugar levels -- they can rationally decide that they may not want to get another dose based on an earnest assessment of the risk from not getting dosed vs. the risk of getting dosed.

People with e.g. allergies to polysorbate choosing not to get vaccinated are not "antivaxxers".

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#153

Post by hirenj »

hirenj wrote: post #42

Here's the paper: https://www.nature.com/articles/s43587-021-00151-2

It's an odd protein they're hitting - GPMNB is expressed pretty widely, so I wonder what the proteoform is that they're targeting/recognising here.

Can't get to the paper using all the usual tricks, so it's hard to say what exactly they're immunising with, which could answer a lot of my questions.

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#154

Post by majkinetor »

pininja wrote: post #121
majkinetor wrote: post #91

Earlier quoted context omitted.

I am pretty sure this would lead to more faster aging. Immune system ages itself, and collateral damage it does during fight response is not 0. There is limited amount of resources for stuff, it the only stuff you do is fighting various shit around, the body will probably turn off other non important stuff for immediate survival. Also, you should think sometimes about aspirin and Spanish fever phenomena.

For people like me who weren’t familiar, aspirin toxicity may have led to the extreme mortality at the peak of the Spanish flu. [0] > The hypothesis presented herein is that aspirin contributed to the incidence and severity of viral pathology, bacterial infection, and death, because physicians of the day were unaware that the regimens (8.0–31.2 g per day) produce levels associated with hyperventilation and pulmonary…

Its more fact then hypothesis. There was also a control group, something we don't have now with vaccines.

5% death in military vs 1% in sanitoriums which used heat therapy. Its amazing what modern medicine did back then, and you know... history repeats.

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#155

Post by tux3 »

pas wrote: post #151
tux3 wrote: post #110

Earlier quoted context omitted.

>Is there a good resource to learn more about this without a Biology degree? Immunology is complicated . Some people call it the second most complicated system, behind the human brain. Someone else has mentioned the Kurzgesagt resources, which are great. If you want something more formal, OME is also a great resource I think. https://onlinemeded.org/spa/immunology >I always assumed the body generated matching snippet…

Do we know how exactly this happens? How fast this process "converges"? How big is the search space and how fast new candidates are generated?

About 3e11 combinations are possible, about 10 billions different antibodies will be generated by a human body (numbers I just sourced from Wikipedia).

The shuffling is done by recombination, which means joining segments of DNA in a random fashion (a similar recombination process is actually used for DNA repair, though with somewhat less randomness!)

There's a lot more to say about all of this, but I don't know how much immunology I can usefully describe in a few HN comments =]

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#156

Post by majkinetor »

derefr wrote: post #117
majkinetor wrote: post #104

Earlier quoted context omitted.

Barely have any acute risk. Its almost impossible to find out what happens after long time, say a decade, with the current approach. > The biggest harm done by taking vaccines you don't really need is probably that the money could have been used for something more useful. What kind of nonsense is that? Its the same as saying "there is no problem in taking any drug, the worst it can get is lose some money". You can't…

> Its almost impossible to find out what happens after long time, say a decade, with the current approach. Most vaccines are much older than a decade. We know who gets vaccines; it's in their medical record, if not centralized anywhere. Longitudinal studies aren't impossible. So any random hospital could do a longitudinal retrospective data-collection study on the consequences for their own patients of either having…

> study on the consequences for their own patients of either having received a given vaccination decades previous or not, no?

No! If you think its possible to pin point exactly what is the source of the problem with decade of various stressors piling up on anybody you should think again. It basically has infinite confounding variables.

> those few poisoned bottles of aspirin did anything to increase the non-contingent risk profile of taking aspirin.

Please educate more about this - do you know that ibuprofen is result of long time search to replace aspirin due to its toxicity (such as stomach bleeding that you will get sooner or later).

Its insane that people outsource medicine. One should strive to know as much as possible about it, with focus on prevention.

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#157

Post by mmastrac »

tux3 wrote: post #155
pas wrote: post #151

Earlier quoted context omitted.

Do we know how exactly this happens? How fast this process "converges"? How big is the search space and how fast new candidates are generated?

About 3e11 combinations are possible, about 10 billions different antibodies will be generated by a human body (numbers I just sourced from Wikipedia). The shuffling is done by recombination, which means joining segments of DNA in a random fashion (a similar recombination process is actually used for DNA repair, though with somewhat less randomness!) There's a lot more to say about all of this, but I don't know how m…

This is a very helpful start for me, thank you

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#159

Post by _ph_ »

pezzana wrote: post #32

> The team, including Juntendo University professor Toru Minamino, confirmed that mice administered with the vaccine showed decreases in the zombie cells, medically known as senescent cells, and in areas affected by arterial stiffening. By now this has become a trope. "Researchers develop new treatment for {UNTREATED_DISEASE}" ... in mice. Mouse models of human disease are very limited in their predictive ability. Th…

I keep wondering if future generations will assume we had a special worship for mice considering how many diseases we tried to cure in mice :p

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#160

Post by trhway »

majkinetor wrote: post #97
hn_go_brrrrr wrote: post #52

Earlier quoted context omitted.

Some libraries don't have certain books. Vaccines buy those books for your library (and, as you say, put them in the front).

Not those books. More like snippets of those books.

and then second edition of the book comes out with that snippet deleted or updated to look completely different.
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