Fisetin is quite cheap and has been shown to eliminate senescent cells: https://pubmed.ncbi.nlm.nih.gov/30279143/
>Fisetin reduced senescence in a subset of cells in murine and human adipose tissue, demonstrating cell-type specificity.
As someone who works and publishes in a related field, this particular phrasing should be interpreted as meaning that Fisetin is unproven as a senolytic.
There is strong evidence that young children in congregate daycare have substantially stronger immune systems than children cared for at home who are only exposed to family members.
Could you link to that strong evidence? A lookup of systematic reviews on Cochrane & Epistemonikos paints the opposite picture, with a positive correlation between daycare attendance and respiratory tract disorders or asthma.
You got it:
Roslund, M. I., Puhakka, R., Grönroos, M., Nurminen, N., Oikarinen, S., Gazali, A. M., ... & ADELE research group. (2020). Biodiversity intervention enhances immune regulation and health-associated commensal microbiota among daycare children. Science advances, 6(42), eaba2578.
Could you link to that strong evidence? A lookup of systematic reviews on Cochrane & Epistemonikos paints the opposite picture, with a positive correlation between daycare attendance and respiratory tract disorders or asthma.
You got it: Roslund, M. I., Puhakka, R., Grönroos, M., Nurminen, N., Oikarinen, S., Gazali, A. M., ... & ADELE research group. (2020). Biodiversity intervention enhances immune regulation and health-associated commensal microbiota among daycare children. Science advances, 6(42), eaba2578.
Thank you! Interesting to see an intervention trial. n=75 is what it is, given the possible confounders (could not control home environment, etc) but I'll be interested to read that in more details =)
Jobs are not the sole way to distribute resources. In fact they are a rather recent way (in human history) to do so. And they're going away anyway soon enough, as automation develops.
Great, a gigantic underclass of people forever stuck with no upward mobility!
1. Removing senescent cells extends life by 30-40% with huge quality of life improvements in the last 25% of the life (relative to control), in mice. This isn't an elimination of all aging, but quite a valuable thing regardless. Eventually, other causes of aging would kick in and still cause death, without a single senescent cell in your body (e.g. DNA methylation). 2. I believe all governments should create Warpspee…
I'm sorry but so many people are waiting for the boomers to die and relinquish control over our lives. I'm not sure we should warp speed this quite yet
1. Removing senescent cells extends life by 30-40% with huge quality of life improvements in the last 25% of the life (relative to control), in mice. This isn't an elimination of all aging, but quite a valuable thing regardless. Eventually, other causes of aging would kick in and still cause death, without a single senescent cell in your body (e.g. DNA methylation). 2. I believe all governments should create Warpspee…
> They'd work So less jobs for young people.
We also have to take care of old people, and the less we have to do that for the period of their lives, the cheaper everything could be because there are less dependents to support. A countries economy is often reflected in their dependent / non-dependent ratio, and the less non-dependents you have, the better economies perform!
1. Removing senescent cells extends life by 30-40% with huge quality of life improvements in the last 25% of the life (relative to control), in mice. This isn't an elimination of all aging, but quite a valuable thing regardless. Eventually, other causes of aging would kick in and still cause death, without a single senescent cell in your body (e.g. DNA methylation). 2. I believe all governments should create Warpspee…
> They'd work So less jobs for young people.
(a) In the current economic model jobs are simply not a limited resource. For instance, immigration creates jobs because among other things, you need more resources to sustain more people.
(b) In the future, there will be more humans than jobs anyways thanks to automation and this is a problem we are going to have to face one way or another. Social contract will change, and the economy will need to be refactored commensurately.
1. Removing senescent cells extends life by 30-40% with huge quality of life improvements in the last 25% of the life (relative to control), in mice. This isn't an elimination of all aging, but quite a valuable thing regardless. Eventually, other causes of aging would kick in and still cause death, without a single senescent cell in your body (e.g. DNA methylation). 2. I believe all governments should create Warpspee…
> They'd work So less jobs for young people.
This is a deep misunderstanding of what jobs are.
They're not "things" that exist in a limited supply.
You can think of them as relationships between people.
When population increases, no one worries that society will "run out" of friendships or marriages. Jobs work the same way.
Jobs are not the sole way to distribute resources. In fact they are a rather recent way (in human history) to do so. And they're going away anyway soon enough, as automation develops.
Great, a gigantic underclass of people forever stuck with no upward mobility!
Yes, what will we do without the famous upward mobility of the factory worker?
Seriously though, the majority of humans never see material upward mobility in their lifetimes, and a world without mandatory low-wage jobs per se isn't necessarily a world without upward mobility.
I have a rare condition related to insulin resistance and diabetes, blood sugar spikes greatly worsen my health. Discovered that vaccines spike sugar prety significantly after getting my two shots this year. Won't be getting boosters anytime soon as the side effects were gruesome.
Wouldn't that make you an antivaxxer? You surely don't want to be mixed up with that crowd, do you?
I would like to be able to discuss vaccines, side effects, contraindications, without hysteria. But that has become impossible.
E.g., I have seen a peer-reviewed report of an RCT indicating that loading up on argenine reduces side effects from COVID spike-protein vaccines, in people who have trouble with those. It seems like an easy choice, because argenine is easy to spike -- just eat lots of nuts -- and is at worst mostly harmless. That seems like something that could be discussed sanely, but even that draws trouble.