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Japanese scientists develop vaccine to eliminate cells behind aging

japantimes.co.jp

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Re: Japanese scientists develop vaccine to eliminate cells behind aging

#91

Post by majkinetor »

JohnJamesRambo wrote: post #2

Sign me up for this the second it is available. As an aside, to spite anti vaxxers I’m on a mission to get every vaccine I can. I want my bloodstream to be like the Library at Alexandria before it burned down.

I am pretty sure this would lead to more faster aging. Immune system ages itself, and collateral damage it does during fight response is not 0. There is limited amount of resources for stuff, it the only stuff you do is fighting various shit around, the body will probably turn off other non important stuff for immediate survival.

Also, you should think sometimes about aspirin and Spanish fever phenomena.

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#92

Post by rmbyrro »

pezzana wrote: post #32

> The team, including Juntendo University professor Toru Minamino, confirmed that mice administered with the vaccine showed decreases in the zombie cells, medically known as senescent cells, and in areas affected by arterial stiffening. By now this has become a trope. "Researchers develop new treatment for {UNTREATED_DISEASE}" ... in mice. Mouse models of human disease are very limited in their predictive ability. Th…

I guess if it does NOT work on mice, it's highly unlikely to work on humans? In this case, it might be good predictor of failure, which can save a lot of money. Just speculating...

Also, if something really bad goes on mice, we can avoid having that happening to humans. Which I would also value a lot.

I mean, it seems to me experimenting on mice might be worth it.

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#93

Post by webwielder2 »

mmastrac wrote: post #87
tux3 wrote: post #64

Earlier quoted context omitted.

You have antibodies that will bind to just about anything foreign, including viruses that your body has never seen before, M-type immunoglobulin (IgM). It's the kind of antibodies that responds in the first phases of an infection. The problem is that IgMs are not very specific. They bind to a lot of things, but they bind poorly. In the library of Alexandria analogy, it's like a book that happens to mention a subject…

Is there a good resource to learn more about this without a Biology degree? I always assumed the body generated matching snippets at random and the law of large numbers would result in a match eventually.

https://www.amazon.com/Immune-Kurzgesagt-gorgeously-illustra...

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#94

Post by ekianjo »

dr_dshiv wrote: post #26
JohnJamesRambo wrote: post #2

Sign me up for this the second it is available. As an aside, to spite anti vaxxers I’m on a mission to get every vaccine I can. I want my bloodstream to be like the Library at Alexandria before it burned down.

I’m with you. I’ve gotten vaccinated for everything my doctor lets me. Japanese Encephalitis? Pshaw. I don’t even know what it is, but good luck with my immune system. It’s like getting a superpower in a video game! And, vaccines have general positive effects of health: https://ec.europa.eu/research-and-innovation/en/horizon-maga...

> And, vaccines have general positive effects of health: https://ec.europa.eu/research-and-innovation/en/horizon-maga...

If you believe that vaccines may have potentially positive effects beyond their original scope, you must also be ready for the opposite, potential negative effects beyond their original scope. If you don't, you are just being brainwashed by big Pharma.

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#95

Post by majkinetor »

mmastrac wrote: post #87
tux3 wrote: post #64

Earlier quoted context omitted.

You have antibodies that will bind to just about anything foreign, including viruses that your body has never seen before, M-type immunoglobulin (IgM). It's the kind of antibodies that responds in the first phases of an infection. The problem is that IgMs are not very specific. They bind to a lot of things, but they bind poorly. In the library of Alexandria analogy, it's like a book that happens to mention a subject…

Is there a good resource to learn more about this without a Biology degree? I always assumed the body generated matching snippets at random and the law of large numbers would result in a match eventually.

AFAIK it does.

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#96

Post by ekianjo »

rmbyrro wrote: post #92
pezzana wrote: post #32

> The team, including Juntendo University professor Toru Minamino, confirmed that mice administered with the vaccine showed decreases in the zombie cells, medically known as senescent cells, and in areas affected by arterial stiffening. By now this has become a trope. "Researchers develop new treatment for {UNTREATED_DISEASE}" ... in mice. Mouse models of human disease are very limited in their predictive ability. Th…

I guess if it does NOT work on mice, it's highly unlikely to work on humans? In this case, it might be good predictor of failure, which can save a lot of money. Just speculating... Also, if something really bad goes on mice, we can avoid having that happening to humans. Which I would also value a lot. I mean, it seems to me experimenting on mice might be worth it.

> I guess if it does NOT work on mice, it's highly unlikely to work on humans?

There is virtually no relationship whatsoever between what works in mice and humans. Such headlines are completely ridiculous by now: the track record of applicability is a train wreck.

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#97

Post by majkinetor »

hn_go_brrrrr wrote: post #52
blip54321 wrote: post #7

Earlier quoted context omitted.

You already have the Library of Alexandria. That's your lymph nodes. What vaccines do is move some books to the front of the building, so your dentritic cells don't have to spend a few days finding them. You want the right books at the front. A mission to move all the books to the front is perhaps misguided.

Some libraries don't have certain books. Vaccines buy those books for your library (and, as you say, put them in the front).

Not those books. More like snippets of those books.

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#98

Post by clairity »

gremloni wrote: post #75
mensetmanusman wrote: post #12

For the sake of discussion, which age would you want to pause at? 16, 24 for insurance reasons?

Probably around 28 so I’m done growing to my final height.

observing professional sports, you find that despite physical fitness/attributes having already plateaued in the early-mid twenties, people reach peak athletic performance in our late twenties when our mental facilities have fully matured and we have some modicum of experience.

27-29 is probably exactly the maximizing range, for this reason.

Re: Japanese scientists develop vaccine to eliminate cells behind aging

#100

Post by kijin »

tux3 wrote: post #76
dr_dshiv wrote: post #26

Earlier quoted context omitted.

I’m with you. I’ve gotten vaccinated for everything my doctor lets me. Japanese Encephalitis? Pshaw. I don’t even know what it is, but good luck with my immune system. It’s like getting a superpower in a video game! And, vaccines have general positive effects of health: https://ec.europa.eu/research-and-innovation/en/horizon-maga...

I'm not going to tell you that you're wrong, but I would be more careful than that. Infections can be the trigger for auto-immune diseases. We're not sure precisely how, but there seems to be a complex combination of genetic and environmental factors. Your immune system is very much not playing games, it's in the business of reacting on a hair trigger, and doing more damage to foreign bodies than it does to your own…

The risk/benefit calculation depends on where you live and/or plan to travel. I fear I'm beginning to forget what life was like before Covid, but IIRC people used to travel quite a lot.

For example, Japanese encephalitis is rare in Japan, but only because many Japanese people have been vaccinated against it. It's endemic in most other parts of east, southeast, and south Asia. It kills 10K+ people every year, and it spreads through mosquito bites just like malaria. But most travelers only worry about malaria.

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