Live data from Hacker News

Pfizer and Biontech provide update on Omicron variant

pfizer.com

271–280 of 717 posts

Re: Pfizer and Biontech provide update on Omicron variant

#271
post #266

Has anyone seen research around mix and match? As in which is better, stay with the original or get a different booster? Especially mRNA followed by J&J, and J&J followed by mRNA? Additionally, is there any benefit to Pfizer followed by Moderna and vice versa.

Yes, there's been some research in that direction, of course I can't find the link right now ... If I remember right, core result was that using the other mRNA for booster doesn't hurt and might provide a small benefit.

Re: Pfizer and Biontech provide update on Omicron variant

#272

I have a few relatives in the medical field (all vaxxed and boosted) that have explained the booster shot is just more of the same stuff - they haven't had time to make a new recipe.. so isn't this just the same study all over again? i.e 2 shots had high protection in the beginning and waned over time. Can we expect the same from the booster shot?

From reading around (not a biologist), I get the impression that there's some kind of super-linear immunity building, not just waning protection. Standard children's vaccines often have a few doses, and not evenly spaced. Soo... you're building up better immunity against the "baseline" virus with each dose. That immunity translates to some (reduced) immunity to the variants. But if the "baseline" is high enough, you…

My understanding is that there is poor evidence that any of the vaccines cause a statistically significant increase in blood clots over any other vaccine-- that the act of getting an immunization can (very rarely) trigger a blood clot regardless of what it is and COVID just happens to be in the hyper-sensitive spotlight.

Re: Pfizer and Biontech provide update on Omicron variant

#273
post #149

I bet they had leaked this article to Wall st. yesterday and that's why we saw the markets rise sharply.

The intense antagonism towards any criticism of the reality of corporate collusion with the news media and Wall Street on HN leaves me confused and depressed.

The moment to have any critique against capitalism there is an invisible vocieless army of downvoters to suppress any chance for reality to invade the bubble of libertarianism on here. I get it, this is hosted on a capitalist funding platform, just do not pretend this is a refuge for inquiring thought.

You really think this does not happen, that people on Wall Street do not get inside information before the rest of you suckers get it?

Re: Pfizer and Biontech provide update on Omicron variant

#274

If I'm reading this correctly, this is "protection against severe disease" and has little to do with transmission. The National Airport Data from Israel seems to suggest "the absolute number of infected individuals in the Vaccinated (boosted) group is likely to be at least as high as in the Unvaccinated" [0] So it seems to me that as long as we all remain obsessed with case numbers and not actual hospitalizations and…

Maybe, maybe not. It is clear, even to someone with zero background in vaccines, that the COVID vaccines are no resulting in sterilizing immunity. Everyone said as much since the first trials. What does this mean? IMHO it means that once we reached sufficient levels of vaccinations (no idea what that would be, definitely above 70%) COVID will be nothing more than a severe flue / cold for most of the population, if th…

It was already on the scale of a cold approximately for some 90%+ of people. This virus is mild or asymptomatic in the vast majority of cases and that has been apparent for a long time. The only possible justification for vaccines at this point is to minimize overloading of hospitals because of the contagious nature of the virus, the overall complication rate is still very low.

>anti-vaxxers (among a lot of things with them). They don't want the shots because a) COVID is just a flew (and simultaniously a deadly bio weapon the Chinese spread in order to win a global economic war...)

Maybe the problem is that people who are against covid vaccines are being a) slandered as anti-vaxxers and b) lumped in with all sorts of other conspiracists.

Re: Pfizer and Biontech provide update on Omicron variant

#276

Earlier quoted context omitted.

Is there a good reason that they haven't updated their vaccine for Delta, which has been out for much longer than 3 months? Over 99% of cases in the US are Delta now, which the original jab wasn't designed for.

> Delta now, which the original jab wasn't designed for. Current vaccines have still been "highly effective" against Delta, so I think that's why this hasn't been done: there's no point in using the big guns now when the existing weapon works well, and you might really need the big gun soon (and you can't know when). So it's better to keep it in reserve. The question now is, is Omicron "it" ?

By their own data, it’s less effective against Delta than the targeted strain. And the massive spike in excess deaths within heavily vaccinated states/countries this past fall was a pretty good sign we would have benefitted from an updated vaccine.

Re: Pfizer and Biontech provide update on Omicron variant

#277

If I'm reading this correctly, this is "protection against severe disease" and has little to do with transmission. The National Airport Data from Israel seems to suggest "the absolute number of infected individuals in the Vaccinated (boosted) group is likely to be at least as high as in the Unvaccinated" [0] So it seems to me that as long as we all remain obsessed with case numbers and not actual hospitalizations and…

The reason why people are obsessed with case numbers and not deaths is that case numbers control the case numbers in the insufficiently immunized which predicts death toll 3 weeks ahead of time. Why would you want to control a system with 2-3 weeks of additional lag in your input data when case numbers (a thing that is somewhat easy to measure) correlates so well future deaths? Ideally politician would have some fami…

That’s not necessarily true. If you suddenly start testing low risk people you weren’t testing before, then you can get an increase in cases without necessarily an increase in death.

For example, if you implement a travel rule that every traveler needs to get tested a day before they leave and a day after they arrive, then you’re going to see an increase in cases (both real and false positives).

Re: Pfizer and Biontech provide update on Omicron variant

#278

Earlier quoted context omitted.

This has always been my fear. I'm vaccinated (Moderna) and got COVID in September. I recovered quickly - about 3 days. But I'm worried that my body did not get to have a proper immune response and that as such, I'll have to continue get vaccinated forever whereas if I had just gotten COVID without the vaccine maybe I would be set. But I haven't found _much_ data to back up this concern.

There is little evidence right now that immunity through a natural infection is better than immunity from a vaccine. Given the strains circulating now I don’t think your concern is valid. Vaccines are better and less risky than having your naive immune system deal with covid. Maybe that will change with a future strain (though I’d bet against it), but it isn’t the case now.

> Vaccines are better and less risky than having your naive immune system deal with covid.

Agreed. However, many people are not in that position. For those who have been infected but not vaccinated, they have experienced immune systems and must evaluate information from that starting point.

Re: Pfizer and Biontech provide update on Omicron variant

#279
post #186

If I'm reading this correctly, this is "protection against severe disease" and has little to do with transmission. The National Airport Data from Israel seems to suggest "the absolute number of infected individuals in the Vaccinated (boosted) group is likely to be at least as high as in the Unvaccinated" [0] So it seems to me that as long as we all remain obsessed with case numbers and not actual hospitalizations and…

That’s a weird way to phrase your second paragraph, considering hospitals have been close to full very recently in parts of the us. https://protect-public.hhs.gov/pages/hospital-utilization

Hospital beds were "maxed out" before the pandemic. [0] at around 64%. They are sitting at around 78% on average now, with hard hit areas at around 80-85% according to your link. These are almost all at-risk and unvaccinated people. That's my point. If mandates and lockdowns are based on case counts instead of actual dire outcomes, then I fear we're going to continue seeing strange policies and laws for people at little to no risk, namely children and the vaccinated.

[0] https://www.webmd.com/lung/news/20200326/us-hospital-beds-we...

Re: Pfizer and Biontech provide update on Omicron variant

#280

Earlier quoted context omitted.

There's the whole t-cell and b-cell stuff that protects from serious disease but it's much harder to test/measure so you don't get these rapid headline grabbing lab studies. T-cells as I understand it are much less likely to be thrown off by spike mutations because they react to whole genome of virus (edit: T-cells from an infection that is).

This is not my area but isn't the point of the mRNA vaccines that that virus' DNA is never introduced into your body? You only end up with a narrow transcribed slice of that DNA targeting a specific protein. I've also never heard of your immune system targetting a genome; how is it generally gaining access to that genome when it is encapsulated? My understanding of the spike targeting is that COVID is only so infecti…

oh yeah thats a point, t-cells will only be able to react to the things that they've seen
Post reply on HN