1) Chrome crashes all the time to the point of almost being unusable. I've tried removing extensions, and Flash and it doesn't seem to matter. I also have a problem where typing in Chrome's address bar is like typing in molasses. Each letter take about a second to appear. This problem started after my upgrade to Lion.
2) TweetDeck seems to throw the entire windowing system into disarray. Weird things like if I try to minimize the app, it'll sometimes automatically pop back up. If TweetDeck is running in the background, and I'm typing in the Chrome address bar, my system will sometimes bring-forward an entirely different application to the foreground. If I close TweetDeck, these problems all go away. I've tried re-installing both TweetDeck and AIR and neither seems to fix the problem.
I love OSX and my MacBook Pro, but I hate the fact that an OS upgrade I paid for made my overall experience using the device worse.