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Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

fiercebiotech.com

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Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#691

Post by Qub3d »

azinman2 wrote: post #688
HWR_14 wrote: post #372

Earlier quoted context omitted.

>Less than two years from lab to clinic is highly unusual. I assume like most other COVID vaccines/treatments, the timeline is shrunk by going straight to more expensive phases of the trial instead of having preliminary ones of escalating cost and confidence. Or at least prepping for them. For instance, all the vaccines started setting up commercial production around the same time they started trials, because it's no…

And that was due to the wisdom of operation warpspeed. Trump is under credited for this (whether his idea or not, he could claim it as such). What’s shocking to me is that he hasn’t been more pro-vax given we have the vaccines we do because of his administration.

Operation Warp Speed is, to me, an indication of the power of government "intertia". Trump changed a lot of things, and while an uncomfortable amount of the U.S. government seems to run on "tradition" that isn't actually law, after 4 years of unchecked assault it was only at the very end that it really got crazy.

Warp speed is the work of career guys. Not even Fauchi -- he was important, but these ideas are put together, presented, and executed by the unknown 9-to-5ers.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#692

Post by krapp »

azinman2 wrote: post #688
HWR_14 wrote: post #372

Earlier quoted context omitted.

>Less than two years from lab to clinic is highly unusual. I assume like most other COVID vaccines/treatments, the timeline is shrunk by going straight to more expensive phases of the trial instead of having preliminary ones of escalating cost and confidence. Or at least prepping for them. For instance, all the vaccines started setting up commercial production around the same time they started trials, because it's no…

And that was due to the wisdom of operation warpspeed. Trump is under credited for this (whether his idea or not, he could claim it as such). What’s shocking to me is that he hasn’t been more pro-vax given we have the vaccines we do because of his administration.

>What’s shocking to me is that he hasn’t been more pro-vax given we have the vaccines we do because of his administration.

He made vaccinations a partisan wedge issue to such a degree that he can't afford to walk back from it if he wants to run again in 2024, similar to the Republicans' former position on Obamacare.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#693

Post by felistoria »

azinman2 wrote: post #688
HWR_14 wrote: post #372

Earlier quoted context omitted.

>Less than two years from lab to clinic is highly unusual. I assume like most other COVID vaccines/treatments, the timeline is shrunk by going straight to more expensive phases of the trial instead of having preliminary ones of escalating cost and confidence. Or at least prepping for them. For instance, all the vaccines started setting up commercial production around the same time they started trials, because it's no…

And that was due to the wisdom of operation warpspeed. Trump is under credited for this (whether his idea or not, he could claim it as such). What’s shocking to me is that he hasn’t been more pro-vax given we have the vaccines we do because of his administration.

I think he was recently boo'd at a rally because he told people to get vaccinated.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#695

Post by apendleton »

nradov wrote: post #60
phh wrote: post #13

> Pfizer used data on patients who were treated within three days of symptom onset as the headline finding in its press release > There were six hospitalizations and no deaths among the 607 patients who received Paxlovid within five days of symptom onset, compared to 41 hospitalizations and 10 deaths in the placebo cohort. > Like Merck, Pfizer excluded people vaccinated against COVID-19 from its late-phase study. No…

Monoclonal antibody treatments are also commonly administered about 3 days after symptoms onset. They have proven to be somewhat effective in real life, although they still aren't being given to some patients who could potentially benefit.

The monoclonal therapies are also administered by IV in a clinical setting, whereas this can be taken at home and could probably even be delivered. It should be even easier to make it within the three-day window with this treatment.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#696

Post by dang »

roenxi wrote: post #86

> This is a completely novel molecule... Then do we understand the risk profile of this thing? That sounds like the sort of innovation that people would want to be at the back of the queue for. Side effects don't have to happen in the next 6 months.

We detached this subthread from https://news.ycombinator.com/item?id=29119057.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#697

Post by dang »

deworms wrote: post #668
rob_c wrote: post #529

Grand. Anything which stops the idiots stopping us from getting back on with our lives is good. Not for me thanks, but it gives people options to make decisions for themselves.

By now you should have noticed that you're not "getting back on with your lives" no matter how good a boy you are and how many freedoms you give up. You should have resisted this from the start, this is your choice.

Please don't take HN threads further into flamewar. It makes discussions predictable, tedious, and nasty.

https://news.ycombinator.com/newsguidelines.html

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#698

Post by cockzor »

cossatot wrote: post #201
stronglikedan wrote: post #125

Earlier quoted context omitted.

> some assholes will use it as an excuse not to get vaxxed Well, they've succeeded in holding out long enough, now that there's no longer a good reason to get vaxxed. Because, as most people are starting to realize, the pandemic is over (at least in the US).

A simple look at the time series shows that this is not the case in many places (e.g., Oregon, where I live): https://www.nytimes.com/interactive/2021/us/oregon-covid-cas...

It isn't the case!??

Holy shit! There's a pandemic!

Get the kids and run and hide!

Holy fucking shit!!!

PANDEEEEMMMIIICCC!!!! It's coming right for us!!!

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#699

Post by apendleton »

shoto_io wrote: post #283

This is Pfizer’s antiviral drug. Merck’s drug might be effective as well, but if seems like to be also a drug with many side affects interfering with your genome. Getting vaccinated looks like a better option to me. Anyone know if the Pfizer one works similarly? https://www.forbes.com/sites/williamhaseltine/2021/11/02/har...

Per the article:

> As a protease inhibitor, Paxlovid is free from the theoretical DNA-alteration risk tied to the mechanism of action of Merck’s molnupiravir.

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