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Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

fiercebiotech.com

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Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#441

Post by simoneau »

salemh wrote: post #352
jayknight wrote: post #260

Earlier quoted context omitted.

This is a good article. I'm firmly on team do-what-it-takes-to-stop-the-spread, but no one has an exit strategy. I got a booster and we have appointments for two of our three kids to get there first shot. By mid-December I'm hoping to not have to think much about it anymore. https://www.theatlantic.com/health/archive/2021/11/what-amer...

Your children do not need it - perhaps you should evaluate whether they are in an 'at risk' category like the Nordics https://www.nature.com/articles/d41586-021-01897-w In the US, 340 children under 17 have died from Covid. Total. During the same period, 187 have died from the flu, and over 51,000 children have died from all causes: https://www.cdc.gov/nchs/nvss/vsrr/covid_weekly/index.htm#Se... Sweden halts Moderna:…

I though most of the point of vaxing children and other low-risk groups is to stop the spread, not for their own individual safety. Reducing the chance they'll infect grandma. And reducing the circulating pool of infections to prevent more virulent strains from developing. Have I got this wrong?

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#442

Post by ceejayoz »

jtbayly wrote: post #435
ceejayoz wrote: post #347

Earlier quoted context omitted.

One of Pfizer's trial vendors falsified information. https://www.cbs17.com/news/north-carolina-news/fact-check-re... > The Pfizer Phase III trial involved 44,000 people and 153 locations. From August 2020 through Sept. 17, 2020 — when she was fired — Jackson told CBS 17 that Ventavia accounted for at least 1,200 of those people and accounted for three sites. The author of the BMJ piece is quoted as saying “people are…

Wait a minute. I don’t see any political position in the comment you’re replying to. I don’t even see a hint of one. I can’t even figure out what political position on what topic would be likely.

The author was obviously aware of the possibility that "one of Pfizer's vendors did a bad thing" would likely be turned into "Pfizer bad/scary!" (with the implication that doubt should be cast on the vaccines/meds) as it is here.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#443

Post by [deleted] »

throwawaymedia wrote: post #337

Before everyone becomes super excited, I want you all to read this article from Nov 2: https://www.bmj.com/content/375/bmj.n2635 Read it carefully. Pfizer falsifies clinical data and covers up significant adverse effects. FDA knows about all of that and covers their asses. Whatever comes from Pfizer will be authorized without any questions being asked. It's not even a legislation, but a straight up internal arrangeme…

[deleted]

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#444

Post by EvanAnderson »

gfodor wrote: post #379
spazrunaway wrote: post #297

Earlier quoted context omitted.

Data shows that being vaccinated divides your odds of dying and being hospitalized from covid by about 10. There's no evidence I'm aware of showing that the vaccines create additional risk anywhere close to outweighing that benefit.

There is. Because kids (basically) don’t die from COVID. The side effect risk, while small, is material in a risk calculation for them, since their entire risk from the disease is small. At a minimum, mandating it for kids (as is openly stated to be the plan in CA) is unethical.

Can you point me in the direction of studies comparing side effect risks for young children against COVID-19 risks for children? Presumably there's such a thing that you're basing your opinion on. I would find that useful, given that I have an 8 y/o who is now vaccine-eligible and her mother and I are discussing.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#445

Post by jdhn »

GhettoComputers wrote: post #357
orra wrote: post #144

I am thinking: if and when this is approved, we have to think about distribution. This drug is fantastically effective at preventing hospitalisation and death, if administered within three days of symptom onset. That gives quite a long time! But we still need to make it easy to take. Do pharmacies give it out? ER rooms? We don't want to wait until people are hospitalised; we are trying to avoid that. So when you test…

Who is the market for this? The assumption is that you give it ASAP and people want to take it. If people aren’t interested in vaccinations they may not want it either, and the vaccines are already very effective at preventing these issues.

I'd say that this will appeal to people who are covid vaccine skeptical. If you're skeptical of the mRNA vaccines, you'd probably be in favor of this treatment than the vaccines.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#446

Post by swader999 »

wincy wrote: post #169
colordrops wrote: post #110

Does anyone have a sense as to when US society will completely eliminate COVID measures? Is it just me or is there no clear exit criteria anymore? This will go on forever without exit criteria.

I live in Kansas and have basically forgotten COVID is a thing. The people who wanted to get vaccinated like me have and those who haven’t, haven’t. Nobody asks about it and no businesses have any sort of mask requirements. Half of the people at the grocery store wear masks and the other half don’t. Everyone seems to be getting along. Next door in Kansas City Missouri I stopped at a gas station and an employee was sh…

It may be a forgotten thing but the new federal mandates are coming that to work you must be vaccinated.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#447

Post by penultimatebro »

TheOtherHobbes wrote: post #359
mostertoaster wrote: post #192

Earlier quoted context omitted.

Oh I think it will be gladly accepted by unvaccinated folk. The reason being is most unvaccinated people don’t believe it isn’t effective, they don’t like being forced to protect themselves by a bunch of moral busybodies. I just accepted as soon as we saw that covid was spreading so quickly, welp I’m gonna get that. I figured I wouldn’t be that affected by it and wasn’t. Our parents said, well if I get it I get it, a…

Nice story. Meanwhile at least 5 million are dead - 750,000 in the US alone. How does your story help their families?

Important question:

Did they die from COVID-19 or did they with COVID-19?

Italy just revised their numbers and it’s quite a significant difference.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#449

Post by refurb »

yosito wrote: post #207
roenxi wrote: post #86

> This is a completely novel molecule... Then do we understand the risk profile of this thing? That sounds like the sort of innovation that people would want to be at the back of the queue for. Side effects don't have to happen in the next 6 months.

> Side effects don't have to happen in the next 6 months. If this is a molecule with a short half-life that is broken down and expelled by the body, it isn't going to have random side effects that show up months in the future.

As someone who worked in toxicology, this is absolutely a false statement. This molecule is a covalent binder - it basically attaches itself permanently to proteins. It absolutely could have effects long after the free molecule is metabolized and excreted. The molecule is designed to be selective for the Covid protease but off-target effects are inevitable.

Do I think that is likely? No, because the FDA isn’t stupid and screens for obvious toxicity in cell cultures and lab animals and only then is testing humans allowed. Then those are screened before approval.

Of course the risk isn’t 0%, but it’s pretty low and if you’re at chance of dying or Covid it’s a pretty small risk relatively speaking.

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