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Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

fiercebiotech.com

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Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#301
post #169

Earlier quoted context omitted.

I live in Kansas and have basically forgotten COVID is a thing. The people who wanted to get vaccinated like me have and those who haven’t, haven’t. Nobody asks about it and no businesses have any sort of mask requirements. Half of the people at the grocery store wear masks and the other half don’t. Everyone seems to be getting along. Next door in Kansas City Missouri I stopped at a gas station and an employee was sh…

Pretty much the same story in South Carolina. Outside retail workers, mask usage in my hyper local area is about 2%. Life has been basically completely normal since June 2020.

I live in South Carolina as well, and I can confirm (I think you meant 2021 not 2020?). Most people in my city have been going about life as usual since ~ May if this year. Almost nobody wears masks. Everything is open. And guess what? We’re all good!

The sky isn’t falling. Hospitals aren’t being overrun. Life is good, and I can remember the last time I worried or had anxiety about Covid.

There seems to be a group of people who still believe we can ‘beat’ Covid. That somehow we make it go away, with endless restrictions. In reality, it is here to stay, and we will have to live with it for the rest of our lives.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#302
post #251
post #19

I think it’s hard to overstate what a big deal this is for science. This is a completely novel molecule that appears effective as an antiviral. This would a huge achievement for the field of drug design, and will hopefully lead to all kinds of great medicine.

> This is a completely novel molecule that appears effective as an antiviral. This would a huge achievement for the field of drug design, and will hopefully lead to all kinds of great medicine. According to the Pfizer press release [0] Paxlovid uses Ritonavir [1], which is a known HIV antiviral, originally patented in 1989. At the start of the covid pandemic, chinese scientists even tried Kaletra, a generic that comb…

Yeah, as parent mentioned in another reply below, ritonavir is an antiviral, but has no effect on SARS-CoV-2 (https://pubmed.ncbi.nlm.nih.gov/34048671/). Ritonavir is just used to inhibit CYP and therefore reducing clearance of the drug.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#303

Does anyone have a sense as to when US society will completely eliminate COVID measures? Is it just me or is there no clear exit criteria anymore? This will go on forever without exit criteria.

Florida is essentially back to normal. Cashiers in most of the large grocery chains and ~50% of restaurant workers still wear masks, hit and miss in most other stores. Most people who come to the house don't wear them, for example, have had a contractor, electrician and cleaning crew at the house in the last week. Electrician wore a mask, no one else did. People are vaccinated who wanted it (I am), and optimally a booster will be freely available soon. Schools ended the mask requirement at least in my county a couple weeks ago.

Some businesses require their employees to all be vaccinated. Governor appears to be fighting against that, would not be surprised if those same businesses just don't hire unvaccinated people going forward and the situation is resolved via attrition.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#304
post #227

Earlier quoted context omitted.

> I guess 5 miles difference magically makes COVID much more contagious. No, 5 miles means you have a different government with a different policy response. (The difference itself doesn't justify either side.) That's just inherent in the existence of political borders.

Yeah, that’s the joke

It's a bad one. Because it only works if the numbers are the same across both states.

But Missouri is doing better than Kansas.

So unless the virus is somehow less contagious in Missouri, it seems like Kansas is just being an idiot in this case.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#306
post #292

Earlier quoted context omitted.

Prions are "just" proteins that should get broken down by the body. But they don't, and they cause ‎Creutzfeldt-Jakob in over 10 years after ingesting.

Are you suggesting that every new molecule should be treated as if it were a prion?

I'm not an expert, but I think if a molecule is isolated, it is possible to determine whether or not it is a prion. IIRC, prions are basically misfolded protiens that cause other protiens to misfold, like a corrupted file that passes the corruption on to every copy or derived file until the system crashes. But you can examine them before systemic problems show up. And I believe a prion has to be a protien-like molecule. Again, not an expert.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#307

Earlier quoted context omitted.

I'm not touching any Pfizer drugs with a 10 foot pole. I guess I'm one of the few actually wise humans left.

Interesting. From a quick google search: Pfizer brands include Advil, Bextra, Celebrex, Diflucan, Lyrica, Robitussin and Viagra You never take an advil?

Pfizer also made Celebrex, the anti-inflammatory that they knew caused health issues but they buried them and claimed it was safe.

We are living in an upside down world now. All of a sudden the drug companies are the "good" guys. Since when did the drug companies suddenly become the heroes?

https://corporatewatch.org/pfizer-six-scandals-to-remember/

1986: Pfizer had to withdraw an artificial heart valve from the market after defects led to it being implicated in over 300 deaths. The US Food and Drug Administration (FDA) withdrew its approval for the product in 1986 and Pfizer agreed to pay hundreds of millions of dollars in compensation after multiple lawsuits were brought against it.

2003: Pfizer has long been condemned for profiteering from AIDS drugs. In 2003 for example, it walked away from a licencing deal for its Rescriptor drug that would have made it cheaper for poorer countries.

2011: Pfizer was forced to pay compensation to families of children killed in the controversial Trovan drug trial. During the worst meningitis epidemic seen in Africa, in 1996, Pfizer ran a trial in Nigeria their new drug Trovan. Five of the 100 children who took Trovan died and it caused liver damage, while it caused lifelong disabilities in those who survived. But another group of 100 children were given the conventional “gold standard” meningitis antibiotic as a “control” group for comparison. Six of them also tragically died because, the families said, Pfizer had given them less than the recommended level of the conventional antibiotic in order to make Trovan look more effective.

2012: Pfizer had to pay around $1billion to settle lawsuits claiming its Prempro drug caused breast cancer. Prempro was used in hormone replacement therapy, usually for women going through the menopause. The settlements came after six years of trials and hardship for the women affected.

2013: Pfizer paid out $273 million to settle over 2,000 cases in the US that accused its smoking treatment drug Chantix of provoking suicidal and homicidal thoughts, self harm and severe psychological disorders. Pfizer was also accused of improperly excluding patients with a history of depression or other mental disturbances from trials for the drug. Later, in 2017, a coroner in Australia ruled that the drug had contributed to a man’s suicide. The man’s mother campaigned to change the label on the drug.

2020: Pfizer reached an agreement with thousands of customers of its depo-testosterone drug in 2018 after they sued it for increasing the likelihood of numerous issues, including heart attacks.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#308

Glad I waited instead of taking part in an experiment trial. There was an "easy" solution after all... I wonder what is the gotcha though, since it's a Pfizer study. Maybe something like selling a known molecule 10 times more expensive than before after rebranding it for the new usage?

Why is this drug less experimental than the vaccines?

mRNA treatment is now also called a vaccine. That type of treatment has never been used on the general population until c19 came along and testing standards were reduced. It is a very interesting type of new treatment, but we lack long term data to say it's truly safe.

Same can be said for any patented-molecule treatment. But that's just a new type of molecule, not a whole other type of treatment. Hence I'd say that molecule-drugs are less experimental than mRNA-vaccine jabs.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#309
post #169

Earlier quoted context omitted.

I live in Kansas and have basically forgotten COVID is a thing. The people who wanted to get vaccinated like me have and those who haven’t, haven’t. Nobody asks about it and no businesses have any sort of mask requirements. Half of the people at the grocery store wear masks and the other half don’t. Everyone seems to be getting along. Next door in Kansas City Missouri I stopped at a gas station and an employee was sh…

> I guess 5 miles difference magically makes COVID much more contagious. No, 5 miles means you have a different government with a different policy response. (The difference itself doesn't justify either side.) That's just inherent in the existence of political borders.

I appreciate you explaining that.. allow me to explain something to you.

The parent statement was not literal, making your expansion meaningless and honestly a little stunning.

Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%

#310
post #292

Earlier quoted context omitted.

Prions are "just" proteins that should get broken down by the body. But they don't, and they cause ‎Creutzfeldt-Jakob in over 10 years after ingesting.

Are you suggesting that every new molecule should be treated as if it were a prion?

Actually: Yes.
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