So, is this expensive and patented and does it have limited availability?
they're basically suing the original company who developed monoclonal therapy for COVID and are trying to copy it. This is the first copy.
Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%
81–90 of 1001 posts
Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%
#82Did anyone hear NPR's reporting on this? They said the early study was originally halted BECAUSE of it's positive effects at preventing hospitalization and death... very weird, I hope it is a typo or I'm understanding it wrong...
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Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%
#83Earlier quoted context omitted.
The alternative is what we have right now, ‘scientists’ blathering about their assumptions with the constant disclaimer that nobody really knows for real. Real science does have a price.
> Real science does have a price. I'm not following. Are you under the impression that the COVID-19 vaccine trials weren't similarly double blinded?
No, I am talking about ‘scientists’ telling others that Covid-19 is magically limited to a 1.5m or 6 feet circle (depending in which country you live). Or that they have to be really careful outside, and that it’s more safe to not go for a walk and fatten up in front of the TV. Or that ‘covid 0’ is a valid policy and that if it doesn’t work it is the fault of this week’s scapegoat. And then censoring anyone who would dare to point out the lack of logic.
Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%
#84Earlier quoted context omitted.
The alternative is what we have right now, ‘scientists’ blathering about their assumptions with the constant disclaimer that nobody really knows for real. Real science does have a price.
> Real science does have a price. I'm not following. Are you under the impression that the COVID-19 vaccine trials weren't similarly double blinded?
Seems like some of the emergency nature of C19 development is altering previous ethical guidelines.
Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%
#85Three different headlines, three different efficacy percentages (89%, 90%, and now 85%), all of which originate from Pfizer's own studies. Color me dubious.
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Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%
#86> This is a completely novel molecule...
Then do we understand the risk profile of this thing? That sounds like the sort of innovation that people would want to be at the back of the queue for.
Side effects don't have to happen in the next 6 months.
Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%
#87> Pfizer’s phase 2/3 trial randomized non-hospitalized adult COVID-19 patients who were at high risk of progressing to severe illness to receive placebo or Paxlovid, a combination of the protease inhibitors Oh, a protease inhibitor you say? I was told those were horse dewormers by the media. This whole thing is bullshit. With this much money at stake we were never going to learn the truth.
'There is no relationship at all between the two drugs, said Dr. William A Petri, professor of infectious diseases at the University of Virginia.
“The only way they are alike is that they are both pills,” Petri said.
Dr. Kevin J. Downes, assistant professor of pediatrics at the Perelman School of Medicine of the University of Pennsylvania, agreed, “They are dramatically different molecules. The drugs are different in their structure and their molecular size.”
[...]
Ivermectin binds to glutamate-gated chloride channels and is used to treat parasite infections, said Joseph Glajch, a consultant in pharmaceutical and analytical chemistry.
“These two are so far apart,” he said. “If you look at how they interact with the body..., they don’t even go to the same pathways or receptors.”'
Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%
#88We had reports of people who wanted to take weird-ass drugs-of-the-day just to refuse getting vaccinated. And screaming "conspiracy" when their efficacy was not confirmed to be as high as they expected. Good that we have something that actually works, bad that some assholes will use it as an excuse not to get vaxxed, completely missing the point (among others, trying to prevent something worse than Delta).
I think that crowd will hate on this new drug. It's from Big Pharma, very expensive, it's probably full of GMOs and brain-controlling chips from Bill Gates. They'll stick with their cheap, generic ivermectin.
In Poland the "wonder drug" was amantadine and the "martyr" was dr Bodnar.
Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%
#89Earlier quoted context omitted.
Minus the preventative part.
Preventative of what? Serious disease? - The same/similar (though studies have shown this declines within 6 months). Op is correct. Catching/Transmission? - The current vaccines are systemic and not mucosal, so they don't stop it infecting the upper respiratory tract. - A recent study shows fully-vaccinated households can spread at similar rates to unvaccinated households [1] [1] https://www.thelancet.com/journals/la…
From your own link:
"Vaccination reduces the risk of delta variant infection and accelerates viral clearance."
Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%
#90The data sample is a bit low? 1200 people
This is a randomized clinical trial; participants are recruited into the study using methods that eliminate the biases associated with self-selected participation, like internet or TV polls. You can get statistically valid results from small samples, that apply to very broad populations, using this methodology.