So as good as a vaccine basically?
For protecting yourself, probably, for protecting others and helping prevent the virus from spreading and mutating, no.
Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%
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Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%
#22So as good as a vaccine basically?
Comparable individual outcome, worse societal outcome - you still spread it, so no reduction in overall cases, unlike a vaccine.
Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%
#23> There were six hospitalizations and no deaths among the 607 patients who received Paxlovid within five days of symptom onset, compared to 41 hospitalizations and 10 deaths in the placebo cohort. How does this work? You sign up for the program when you're sick and you might get meds that help you? That would really suck if a loved one was in the program and died because they happened to get the placebo.
They randomly assign people to the control or treatment cohort. Don’t forget there’s also the chance that the treatment gives patients liver cancer or some other yet-unknown adverse outcomes.
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Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%
#24The data sample is a bit low? 1200 people
That's not low for the effect size they're observing. Note that this is a phase 2/3 trial. The safety trials have already occurred.
Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%
#25So, is this expensive and patented and does it have limited availability?
Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%
#26Glad I waited instead of taking part in an experiment trial. There was an "easy" solution after all... I wonder what is the gotcha though, since it's a Pfizer study. Maybe something like selling a known molecule 10 times more expensive than before after rebranding it for the new usage?
Why is this drug less experimental than the vaccines?
Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%
#27> There were six hospitalizations and no deaths among the 607 patients who received Paxlovid within five days of symptom onset, compared to 41 hospitalizations and 10 deaths in the placebo cohort. How does this work? You sign up for the program when you're sick and you might get meds that help you? That would really suck if a loved one was in the program and died because they happened to get the placebo.
> That would really suck if a loved one was in the program and died because they happened to get the placebo.
Trials like this are performed in desperate situations, and you only ever hear about the success stories. Most such trials probably result in no measurable benefit, and run the risk of an even worse outcome than the placebo.
Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%
#28> There were six hospitalizations and no deaths among the 607 patients who received Paxlovid within five days of symptom onset, compared to 41 hospitalizations and 10 deaths in the placebo cohort. How does this work? You sign up for the program when you're sick and you might get meds that help you? That would really suck if a loved one was in the program and died because they happened to get the placebo.
The alternative is what we have right now, ‘scientists’ blathering about their assumptions with the constant disclaimer that nobody really knows for real.
Real science does have a price.
Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%
#29> Pfizer’s phase 2/3 trial randomized non-hospitalized adult COVID-19 patients who were at high risk of progressing to severe illness to receive placebo or Paxlovid, a combination of the protease inhibitors
Oh, a protease inhibitor you say? I was told those were horse dewormers by the media.
This whole thing is bullshit. With this much money at stake we were never going to learn the truth.
Re: Pfizer's oral Covid-19 antiviral cuts hospitalization, death by 85%
#30So as good as a vaccine basically?
I'm excited to hear the results of the pill among the vaccinated. Cutting the risk of severe symptoms among high-risk vaccinated people, and the risk of long covid for everyone is very important. The vaccines are great, but not silver bullets themselves.
"Long covid" is an urban legend.