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CoV–2 Spike Impairs DNA Damage Repair – Inhibits V(D)J Recombination in Vitro

mdpi.com

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Re: CoV–2 Spike Impairs DNA Damage Repair – Inhibits V(D)J Recombination in Vitro

#91

Post by GhettoComputers »

m0zg wrote: post #80
GhettoComputers wrote: post #77

Earlier quoted context omitted.

The issue is that the most vulnerable elderly people get terrible effects or die from the immune response. They need to be healthy enough to receive the vaccine, if they’re old and sickly it’s better to vaccinate everyone around them and continue to keep their immune response up. The second most vulnerable elderly people are prime candidates for vaccination though. They’re not as old, more healthy and less likely to…

> elderly people get terrible effects or die from the immune response. I'm not convinced this is true. As far as I can tell after looking at the data (as thoroughly fucked up and obfuscated as it is) the vaccine is well tolerated in the elderly. Certainly much better tolerated than COVID itself, especially for people 65 and over.

Depends on how poor their heath is. I am not sure if you remember, but they said that everyone should get vaccinated so they can prevent the most vulnerable from getting sick.

Re: CoV–2 Spike Impairs DNA Damage Repair – Inhibits V(D)J Recombination in Vitro

#92

Post by GhettoComputers »

LurkingPenguin wrote: post #82
GhettoComputers wrote: post #33

Earlier quoted context omitted.

"Up to" 6 months isn't long lasting, thats salesmen speak, and the average again was 53% after 4 months. >vaccine effectiveness against infections of the delta variant was high during the first month after full vaccination (93% [95% CI 85–97]) but declined to 53% [39–65] after 4 months. >Reduction in vaccine effectiveness against SARS-CoV-2 infections over time is probably primarily due to waning immunity with time r…

I pointed out that the VE against hospitalization remains high (>90%) at 6 months and you continue to highlight VE against infection. These are not the same endpoints. > People don't want to get infected so they don't get long covid. Notwithstanding the fact there's some evidence the vaccines don't protect as well against long COVID as previously suggested[1], if this is the case and large numbers of people are eager…

Sure, feel free to post the hospitalization rates of delta positive non vaccinated people. What is their delta hospital admissions in comparison? Lets compare those rates.

Many people who got covid didn't go to the hospital, didn't die and were asymptomatic, so that statistic you posted is mostly noise. Most people who take the vaccine don't want to get covid at all.

Re: CoV–2 Spike Impairs DNA Damage Repair – Inhibits V(D)J Recombination in Vitro

#93

Post by [deleted] »

jboggan wrote: post #25
savant_penguin wrote: post #9

"Mechanistically, we found that the spike protein localizes in the nucleus and inhibits DNA..." Can anyone translate?

This is an engineering error at its heart. By design the spike protein were supposed to be expressed and embedded in the surface of the cell where they could be recognized by the immune system. Some proportion of them lingering and having any action within the cell was not foreseen.

[deleted]

Re: CoV–2 Spike Impairs DNA Damage Repair – Inhibits V(D)J Recombination in Vitro

#94

Post by [deleted] »

Consultant32452 wrote: post #36
kevingadd wrote: post #31

Earlier quoted context omitted.

Are you implying that covid-19 was engineered/designed? If not, what are you talking about?

I interpreted it as referring to the spike proteins generated after receiving the mRNA vaccine. They were supposed to have been modified to not be bio-active.

[deleted]

Re: CoV–2 Spike Impairs DNA Damage Repair – Inhibits V(D)J Recombination in Vitro

#95

Post by boomchinolo78 »

salawat wrote: post #5
blip54321 wrote: post #3

Earlier quoted context omitted.

It does imply that the vaccine would also inhibit DNA damage repair. I think the key question is timescale. I suspect this would be a short-term side effect, with no real impact. If not -- if it's longitudinal -- it could be scary. I can't imagine how that would happen, though. Virus would have the same effect, so this isn't an anti-vax argument.

Half-life of mRNA is fairly small, as there is no shortage of enzymes that basically just break it down for recycling. The real problem would have to stem from DNA damage that occurred in the presence of the vaccine that did not either lead to cell death, or get repaired later.

Half-life of mRNA is not small when it is reverse-transcripted. There´s been some misinformation of how mRNA is not reverse-transcripted. mRNA is RNA and all RNA is susceptible of transcription. The messenger part is just a description of it role in a particular process. Sadly, this is the source of many misunderstandings

Re: CoV–2 Spike Impairs DNA Damage Repair – Inhibits V(D)J Recombination in Vitro

#96

Post by boomchinolo78 »

GhettoComputers wrote: post #62
m0zg wrote: post #52

Methinks we won't really know about the consequences of mRNA (or COVID itself for that matter) until many years later. And currently we're flying blind, and a lot of people are driven by heavily politicized, semi-religious fervor, to the point of giving this stuff to healthy 5 year olds who are not in danger of severe disease at all.

The mRNA isn’t the issue, the delivery methods are the problem. The toxicity of the adjuvants is the problem, mRNA is so fragile it needs extreme cold to store, a unique carrier and redosing with boosters to upkeep strong immunity. It’s very safe, but the externalities that are required are the issue. mRNA is not the issue nor is it unsafe, if they could do it without the current adjuvants there would be no issues.

[flagged]

Re: CoV–2 Spike Impairs DNA Damage Repair – Inhibits V(D)J Recombination in Vitro

#97

Post by KB4158 »

koolba wrote: post #38
revolvingocelot wrote: post #21

Earlier quoted context omitted.

edit: this journal might not be worth paying attention to https://en.wikipedia.org/wiki/MDPI#Controversies >Does this finding imply that the vaccine would also inhibit DNA damage repair? Well, yes , but consider the context. If you read the article, and it's almost beyond belief that I have to recommend that you read the article in order to discuss it -- indeed, the information that might assuage your fears is in the…

> Searching for a means by which the vaccine might meaningfully damage your adaptive immune system is ill-advised. Frankly, we've got terrifying amounts of information about the deleterious effects of catching and surviving serious COVID, and administration of a vaccine tends to uncontroversially downgrade the seriousness of the COVID infection that you will almost assuredly get eventually. Thus, even if the vaccine…

Vax injuries/deaths are happening, and these lives are being swept under the rug - or dismissed as sacrifices to the cause. COVID will most definitely not be worse than the vaccine for everyone.
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