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CoV–2 Spike Impairs DNA Damage Repair – Inhibits V(D)J Recombination in Vitro

mdpi.com

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Re: CoV–2 Spike Impairs DNA Damage Repair – Inhibits V(D)J Recombination in Vitro

#51

Post by nik41tkins »

koolba wrote: post #38
revolvingocelot wrote: post #21

Earlier quoted context omitted.

edit: this journal might not be worth paying attention to https://en.wikipedia.org/wiki/MDPI#Controversies >Does this finding imply that the vaccine would also inhibit DNA damage repair? Well, yes , but consider the context. If you read the article, and it's almost beyond belief that I have to recommend that you read the article in order to discuss it -- indeed, the information that might assuage your fears is in the…

> Searching for a means by which the vaccine might meaningfully damage your adaptive immune system is ill-advised. Frankly, we've got terrifying amounts of information about the deleterious effects of catching and surviving serious COVID, and administration of a vaccine tends to uncontroversially downgrade the seriousness of the COVID infection that you will almost assuredly get eventually. Thus, even if the vaccine…

I especially want to understand the effects on developing immune systems. There are obvious no long term studies and kids are rarely seriously sick from the virus itself.

Re: CoV–2 Spike Impairs DNA Damage Repair – Inhibits V(D)J Recombination in Vitro

#52

Post by m0zg »

Methinks we won't really know about the consequences of mRNA (or COVID itself for that matter) until many years later. And currently we're flying blind, and a lot of people are driven by heavily politicized, semi-religious fervor, to the point of giving this stuff to healthy 5 year olds who are not in danger of severe disease at all.

Re: CoV–2 Spike Impairs DNA Damage Repair – Inhibits V(D)J Recombination in Vitro

#53

Post by Vecr »

gmnash wrote: post #20
LurkingPenguin wrote: post #14

The key finding: > Our findings provide evidence of the spike protein hijacking the DNA damage repair machinery and adaptive immune machinery in vitro. We propose a potential mechanism by which spike proteins may impair adaptive immunity by inhibiting DNA damage repair. Although no evidence has been published that SARS–CoV–2 can infect thymocytes or bone marrow lymphoid cells, our in vitro V(D)J reporter assay shows…

According to the CDC, the mRNA vaccines do NOT induce creation of the full spike: https://www.cdc.gov/vaccines/covid-19/hcp/mrna.html > mRNA vaccines tell our cells to make a piece of the “spike protein” that is found on the surface of the SARS-CoV-2 virus. Since only part of the protein is made, it does not harm the vaccine recipient, but it is antigenic and thus stimulates the immune system to make antibodies.

The CDC is obfuscating, or probably lying, depending on your definition. The spike produced from transfected cells is absolutely the whole thing, with two proline insertions, that's it. All the other sequence changes are just optimizations, they don't change the result.

Re: CoV–2 Spike Impairs DNA Damage Repair – Inhibits V(D)J Recombination in Vitro

#54

Post by [deleted] »

LurkingPenguin wrote: post #44
hlieberman wrote: post #34

This is published by a predatory publisher ( https://en.wikipedia.org/wiki/MDPI#Controversial_articles ). According to homozygoat ( https://www.twitch.tv/homozygoat ), it doesn't use real virus (rather, it uses other cells transfected to express some covid proteins), and uses the wrong cell type for the conclusions they try to draw.

So we should ignore everything published by MDPI but take as gospel something stated by a PhD candidate in molecular biology who livestreams on Twitch under the name Homozygoat and has 329 followers there?

[deleted]

Re: CoV–2 Spike Impairs DNA Damage Repair – Inhibits V(D)J Recombination in Vitro

#55

Post by vibrato2 »

Commodore63 wrote: post #12
TravisDick wrote: post #2

I didn't read the article, but my very basic understanding of mRNA vaccines is that they cause your own cells to produce the spike protein so that your immune system can learn to attack it without actually having the virus present. Does this finding imply that the vaccine would also inhibit DNA damage repair? Or is it more like, in combination with the virus, the spike protein inhibits DNA repair?

The spike protein from the vaccine is injected into your muscle and does not circulate through your system.

that was the idea, but it turned out not to be true. and then the manufacturers lied about it and covered it up.

Re: CoV–2 Spike Impairs DNA Damage Repair – Inhibits V(D)J Recombination in Vitro

#56

Post by gfodor »

LurkingPenguin wrote: post #44
hlieberman wrote: post #34

This is published by a predatory publisher ( https://en.wikipedia.org/wiki/MDPI#Controversial_articles ). According to homozygoat ( https://www.twitch.tv/homozygoat ), it doesn't use real virus (rather, it uses other cells transfected to express some covid proteins), and uses the wrong cell type for the conclusions they try to draw.

So we should ignore everything published by MDPI but take as gospel something stated by a PhD candidate in molecular biology who livestreams on Twitch under the name Homozygoat and has 329 followers there?

It depends. If the content in question could possibly cast doubt that the vaccines are anything but 100% safe as drinking a glass of water, then we go with the twitch streamer, NYT journalists, randos on Twitter, etc. If the content in question supports the idea that the vaccines are a silver bullet and must be taken by everyone immediately or they should lose their job and be cast out of public life, then the study involved is now canon and we should label the former groups questioning this as peddling in disinformation.

Re: CoV–2 Spike Impairs DNA Damage Repair – Inhibits V(D)J Recombination in Vitro

#57

Post by haimez »

GhettoComputers wrote: post #15
TravisDick wrote: post #6

Earlier quoted context omitted.

Yeah, for context I'm fully vaccinated and not trying to create distrust of the mRNA vaccines. Just curious because that seems like a pretty bad thing. It makes sense that this would only happen while the spike proteins are actually present in your body. Thanks for the response!

The mRNA vaccines's mRNA has never been the problem its the adjuvant properties such as the PEG allergies and lipid nanoparticles that have been been causing all the issues. I am sure it will be improved, and they're exploring better adjuvants. When were you vaccinated? If its been a while get your booster. https://www.thelancet.com/journals/lancet/article/PIIS0140-6... Effectiveness against infections declined from…

Would anything you’ve learned since your first vaccination make you consider “mixing and matching” for reasons other than supply availability?

Re: CoV–2 Spike Impairs DNA Damage Repair – Inhibits V(D)J Recombination in Vitro

#58

Post by mc32 »

m0zg wrote: post #52

Methinks we won't really know about the consequences of mRNA (or COVID itself for that matter) until many years later. And currently we're flying blind, and a lot of people are driven by heavily politicized, semi-religious fervor, to the point of giving this stuff to healthy 5 year olds who are not in danger of severe disease at all.

I think it makes sense to vaccinate vulnerable populations. Elderly, and those with comorbidities, however, pre-adolescents I don’t think need it, especially as we don’t know long term effects on the young. For old folks, the reward is well worth any risk. For youngsters given their risk profile, I’m not so sure as we lack information given the trials on youngsters were short and we don’t have long term data.

Re: CoV–2 Spike Impairs DNA Damage Repair – Inhibits V(D)J Recombination in Vitro

#59

Post by modzu »

hlieberman wrote: post #34

This is published by a predatory publisher ( https://en.wikipedia.org/wiki/MDPI#Controversial_articles ). According to homozygoat ( https://www.twitch.tv/homozygoat ), it doesn't use real virus (rather, it uses other cells transfected to express some covid proteins), and uses the wrong cell type for the conclusions they try to draw.

your first reference doesn't support your claim

Re: CoV–2 Spike Impairs DNA Damage Repair – Inhibits V(D)J Recombination in Vitro

#60

Post by revolvingocelot »

j16sdiz wrote: post #43
revolvingocelot wrote: post #21

Earlier quoted context omitted.

edit: this journal might not be worth paying attention to https://en.wikipedia.org/wiki/MDPI#Controversies >Does this finding imply that the vaccine would also inhibit DNA damage repair? Well, yes , but consider the context. If you read the article, and it's almost beyond belief that I have to recommend that you read the article in order to discuss it -- indeed, the information that might assuage your fears is in the…

> I'll again point out that however the spike might fuck with B and T cells, the full-blown virus will surely do more. Sure. And the full-blown virus trigger the same immune response and create the same spike protein.. BUT , this is all about risk management. If you live alone in somewhere very low infection rate and don't meet people, there is no point taking this risk. If you need a vaccine, there are safer (but le…

>If you live alone in somewhere very low infection rate and don't meet people

Heh, good luck! Delta's r0 of 6 to 8 is too high to meaningfully avoid. Sure, if you're some sort of hermit, you can probably manage, but if you're in North America, vaccination rates in rural areas will work against you. Frankly, there's no point in taking the risk.

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