CoV–2 Spike Impairs DNA Damage Repair – Inhibits V(D)J Recombination in Vitro

>Does this finding imply that the vaccine would also inhibit DNA damage repair?

Well, yes, but consider the context. If you read the article, and it's almost beyond belief that I have to recommend that you read the article in order to discuss it -- indeed, the information that might assuage your fears is in the very first paragraph -- it's been observed that a consequence of surviving a serious case of COVID is that your immune system is fucked, both during and afterward:

>"SARS–CoV–2 infection extraordinarily affects lymphocyte number and function [3,4,5,6]. Compared with mild and moderate survivors, patients with severe COVID–19 manifest a significantly lower number of total T cells, helper T cells, and suppressor T cells [3,4]. Additionally, COVID–19 delays IgG and IgM levels after symptom onset [5,6]. Collectively, these clinical observations suggest that SARS–CoV–2 affects the adaptive immune system."

Searching for a means by which the vaccine might meaningfully damage your adaptive immune system is ill-advised. Frankly, we've got terrifying amounts of information about the deleterious effects of catching and surviving serious COVID, and administration of a vaccine tends to uncontroversially downgrade the seriousness of the COVID infection that you will almost assuredly get eventually. Thus, even if the vaccine harms you in some way, COVID itself will do worse.

That said, the Discussion section does suggest that there may be improvements to full-spike vaccines in future,

>"indicating that full–length spike–based vaccines may inhibit the recombination of V(D)J in B cells, which is also consistent with a recent study that a full–length spike–based vaccine induced lower antibody titers compared to the RBD–based vaccine [28]. This suggests that the use of antigenic epitopes of the spike as a SARS–CoV–2 vaccine might be safer and more efficacious than the full–length spike."

I'll again point out that however the spike might fuck with B and T cells, the full-blown virus will surely do more.

This is misinformation. From your link:

> Vaccine effectiveness against hospital admissions for infections with the delta variant for all ages was high overall (93% [95% CI 84–96]) up to 6 months.

A post regarding a possible "issue" with the vaccines is a strange place to engage in "get your booster!" fearmongering by highlighting VE against infection as compared to the far more important endpoints of hospitalization and death.

> BNT162b2 is a lipid nanoparticle–formulated, nucleoside-modified RNA vaccine that encodes a prefusion stabilized, membrane-anchored SARS-CoV-2 full-length spike protein.

https://www.nature.com/articles/s41541-021-00369-6

> The two mRNA vaccines in current widespread application (BioNTech-Pfizer and Moderna) (Table 1) are technologically very similar. They contain codon-optimized sequences for efficient expression of the full-length S protein and use the authentic signal sequence for its biosynthesis44,45,46,47 (Fig. 1b).

> The unifying feature of all current adenovirus-vaccine vectors is the replacement of one of the early adenoviral genes (E1) for the full-length SARS-Cov-2 S gene in the adenoviral DNA (Fig. 4a) and the additional deletion of E3

From this post:

> To date, many approved SARS–CoV–2 vaccines, such as mRNA vaccines and adenovirus–COVID–19 vaccines, have been developed based on the full–length spike protein

If the mRNA and adenovirus vector vaccines weren't expressing the full-length spike, this research would be pointless in the context of the vaccines and the researchers wouldn't raise their findings as a possible efficacy and safety issue for the vaccines.