Earlier quoted context omitted.
That's indicative of underlying aggression and can't be extrapolated to other cultures.
I guess, but I'm curious what culture has no aggression at all.
Probably depends on how specific you get with the term aggression
The main thing about Phenylacetone meth is that there's so much of it
151–160 of 371 posts
Re: The main thing about Phenylacetone meth is that there's so much of it
#152Earlier quoted context omitted.
It's the same in the US; you can buy it without a prescription, but you have to have your ID logged.
And there's a limit on how much you can buy at a time, you can only get 15 24-hour pills every 15 days, which means you need a regular pharmacy trip
FDA pressured loperamide manufacturers to stop selling large quantity bottles because people thought eating a whole bottle was a good idea.
Problem: taking massive amounts of loperamide to get an opiate effect is a myth
Of course, the manufacturers were all happy to fall in line anyway and dramatically raise per-tablet prices (and packaging!)
Except one manufacturer.
Several years ago, I bought a 200-ct bottle for US$9 shipped to Canada. Now it's US$36.
Re: The main thing about Phenylacetone meth is that there's so much of it
#153Earlier quoted context omitted.
Great writeup! Just adding on: Other key differentiator between recreational and therapeutic amphetamine usage is the pharmacokinetics: Vyvanse is the best in this regard - it’s actually an amphetamine prodrug that gets converted to amphetamine in the bloodstream over the course of ~2 hours, giving a very smooth release. Adderall achieves a similar end (to a lesser degree) by combining equal ratios of four different…
Adding on: the problem with vyvanse is that there's no way to mess around with the dosage to get it "just right." It's like a more strict version of extended release (EX) and timed release formulations (there's a difference!). Vyvanse is metabolized to d-amphetamine in your blood cells (the specific mechanism escapes me right now), unlike the regular non-prodrug versions which get "metabolized" first in your stomach…
> Vyvanse is metabolized to d-amphetamine in your blood cells
Do you have any more information about this? Can't find it on google - would be very interesting if its true but I'm a bit skeptical - I've never heard about blood cells being a primary site of drug metabolism.
A search turned up:
> "Lisdexamfetamine dimesylate is converted to dextoamphetamine and L- lysine, which is believed to occur by first-pass intestinal and/or hepatic metabolism."
(https://www.accessdata.fda.gov/drugsatfda_docs/label/2007/02...)
According to this, sounds like its mostly intestines and liver, which is much more typical for drug metabolisms.
Re: The main thing about Phenylacetone meth is that there's so much of it
#154Earlier quoted context omitted.
I guess, but I'm curious what culture has no aggression at all.
Probably depends on how specific you get with the term aggression
It sounds like there's a suggestion that cultures where alcohol has no notable effect on overall violence. I'm curious what culture that is.
Re: The main thing about Phenylacetone meth is that there's so much of it
#155Around a week ago, I came across this link here on HN that suggested that there's a new form of meth: https://news.ycombinator.com/item?id=28938888 The theory is that new meth is based on a synthesis using a chemical called P2P rather than the old synthesis that used ephedrine. There are claims that this new form of meth is chemically different in some what that started creating schizophrenia around 2017. However, wh…
I saw a similar post that claimed the new meth caused psychosis and hallucinations, etc. I don’t know much about meth itself but I do know about Adderall. When you take the normal dose (10-30mg) it can cause some euphoria but for the most part it helps you focus, gives energy (makes you more happy, talkative.) But when it is abused (60+mg) it can cause serious psychosis with all kinds of mental side effects. I image…
> When you take the normal dose (10-30mg) it can cause some euphoria but for the most part it helps you focus, gives energy (makes you more happy, talkative.) But when it is abused (60+mg) it can cause serious psychosis with all kinds of mental side effects.
Background: I'm prescribed 20mg/day of extended release Adderall, via a legitimate ADHD diagnosis. If we take the article's "meth is 2x as potent as Adderall" statement at face value, that would mean I'm taking 10mg equivalent of meth per day.
Now, since part of the reason I take this medication is to remember to take my medication (a joke, yes, but not without its kernel of truth!), I've accidentally double dosed myself before. I've also done the same previously when I was prescribed instant release Adderall. In either case, I've never experienced anything like a euphoric high, but I have experienced the kind of "uselessly driven"/tweaker sort of side of it. And, let me tell you, I do not like it when that happens. Although I'm in no hurry to find out, I honestly find it hard to imagine what the high must actually be like in order for people to voluntarily subject themselves to the negative effects of this drug. And, I don't even exceed the therapeutic range when this happens!
I wish there was some way to actually understand why people abuse meth without actually smoking meth myself, which I'm unwilling to do, for obvious reasons.
Re: The main thing about Phenylacetone meth is that there's so much of it
#156Bit of a tangential rant: meth is actually truly really bad, and I wish our drug education growing up hadn’t painted this nebulous concept of “drugs”, because there’s gradations of harm. I’m approaching 40. (Ugh, I hate to admit that.) I grew up during the D.A.R.E. era. Just Say No. Cartoon All-Stars to the Rescue. “Drugs” were this boogeyman, and whatever they were, they would turn you into a junkie instantly. I hav…
Contemporary social policy as a whole appears to be a cycle of reaction and hysteria. There's very little substance to this process, in the form of empiricism or evidenced-based feedback. This cycle appears to be a by-product of our modern information mediums. I think that generations prior to ours (I too am approaching 40) weren't as vulnerable to the whims of society's most easily frightened and manipulated members. I think the only solution is to vote with our feet, and leave the hysterics behind. I suspect this process is well underway, now that the more educated members of society have the ability to work from home.
Re: The main thing about Phenylacetone meth is that there's so much of it
#157Re: The main thing about Phenylacetone meth is that there's so much of it
#158Earlier quoted context omitted.
Amphetamines also cause capillary vasoconstriction which eventually kills off your gums
Pharmacologically, amphetamines are no worse on your mouth than regular nicotine or caffeine usage. And while cigs & coffee aren't necessarily good for your oral health, they also don't generally cause major gum disease and tooth loss. "Meth mouth" is mostly caused by neglect, not the biological effects of amphetamines. Long-term heroin & crack users suffer the same kind of severe tooth decay as meth addicts. If you…
That's incorrect, at least in the case of cigarettes. According to the CDC, you have twice the risk of gum disease if you smoke versus nonsmokers. They also state that the more you smoke and the longer you smoke, the greater your risk. That doesn't directly imply a causal link, but it sure winks really obviously in the direction of one.
https://www.cdc.gov/tobacco/campaign/tips/diseases/periodont...
Re: The main thing about Phenylacetone meth is that there's so much of it
#159Around a week ago, I came across this link here on HN that suggested that there's a new form of meth: https://news.ycombinator.com/item?id=28938888 The theory is that new meth is based on a synthesis using a chemical called P2P rather than the old synthesis that used ephedrine. There are claims that this new form of meth is chemically different in some what that started creating schizophrenia around 2017. However, wh…
Much of the effects of any intoxicant are culturally constructed. Alcohol is widely known for causing aggression, but this effect doesn’t seem to exist in cultures without that association. Nor does it exist in double-blind studies, yet the placebo group becomes more aggressive. You can start with two chemically identical intoxicants, and either by marketing or random path dependencies one gains a reputation in the s…
> In many ways that makes these rumor filled, science light, unsubstantiated media stories about “this is the most dangerous drug ever” incredibly irresponsible. The stories themselves create the cultural preconditions around encouraging more self-destructive behavior among users. What about krokodile?
Re: The main thing about Phenylacetone meth is that there's so much of it
#160The reason Meth use is going up is not due to Meth itself. It counter balances the effects of Fentanyl. I regularly go to Fentanyl overdoses where the bystanders tell me they ran out of "G" or "Glass" and simply overdid it with the "M30's"... Its a fucking nightmare. It used to be "meth" users would say..."At least I am not a dope junky using H." Heroin users would say... "At least I am not a tweaker." Now they are o…
Sorry, for someone who knows next to nothing about drugs can you clarify? I’m assuming “glass” is the meth and the “M30” pills are fentanyl? Or maybe the other way around? And, if you don’t mind, can you explain what you mean by “counterbalance”? I’m assuming it’s like drinking a red bull with vodka? Does it actually “counterbalance” chemically so someone could “safely” (for lack of a better word) take more fentanyl…
> I’m assuming “glass” is the meth and the “M30” pills are fentanyl?
Correct. M30's are opiates pressed to look like percocet - when from the street, typically fentanyl or another potent opioid.