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Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

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Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#121

Post by jinto36 »

lthornberry wrote: post #69
simiones wrote: post #66

Earlier quoted context omitted.

I am not a practitioner, so I have no idea if this is actually plausible, but it would seem absurd to me for an experimental, out-of-left-field treatment for Alzheimers, in a <10 person study, could be denied a control group on ethical grounds. There are tens if not hundreds of millions of Alzheimer's patients not receiving this potential treatment already.

This. There is basically zero chance that an ethics review would see this as a case in which a control group is unethical. I have been through plenty of IRB processes. Resource constraints are a much more plausible explanation - running the study with a control group would cost twice as much (in time as well as money). This is either a pilot to apply for funding to run a better-controlled trial, or it's just not scie…

Thanks for the perspective, I have only done data analysis after the data is generated, and never have actually had to deal with an IRB directly for the design of a study.

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#122

Post by gfodor »

orangepurple wrote: post #77
gfodor wrote: post #72

Earlier quoted context omitted.

If HBOT is potentially beneficial, the proper response to a study is to tell people to raise it to their doctor to see if it makes sense for them.

Doctors are stressed, overworked, and only keep up on cutting edge research at yearly conferences and sometimes through the grapevine. Your typical doctor won't know anything about HBOT.

That’s why you should see a good doctor not a typical one. A good doctor would be interested in any research that is well founded despite being non-consensus. That doesn’t mean that they will endorse it. But people like the person I was replying to cuts them out of the process by presuming they already know the right choice for a patient.

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#123

Post by sdze »

dstick wrote: post #45
sdze wrote: post #22

This approach flopped already for the case of rejuvenation. I doubt this therapy carried any fruits in future.

Citation needed; could you provide sources?

> https://www.lifespan.io/news/media-circus-surrounds-hyperbar...

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#125

Post by naasking »

robbiep wrote: post #118
naasking wrote: post #83

Earlier quoted context omitted.

I assume "the amyloid hypothesis" is the hypothesis that plaques cause Alzheimer's. That hypothesis is indeed dead. There are plenty of successful plaque treatments. Basically none of them are effective.

which does nothing to explain why people with APP mutations such as found in fAd develop early onset Alzheimers. So the mystery of Amyloid and its role in dementias persists

The simplest explanation is that APP mutations cause some other dysfunctions which then causes Alzheimer's. It's these other dysfunctions we should be looking for.

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#126

Post by naasking »

criddell wrote: post #111
naasking wrote: post #93

Earlier quoted context omitted.

Wikipedia is correct to say it's widely believed that plaques cause Alzheimer's, because the new evidence is still encountering resistance. The hallmark of science is falsification. We now have many drugs that remove amyloid plaques with few side effects. Removing plaques does not improve symptoms or halt progression [1, 2]. Furthermore, 60% people over 80 have these plaques but only 10% develop dementia [3]. Ergo, t…

I can't get the whole paper, but your first link seems to be saying that we've put all our eggs into one basket and we are ignoring too many other theories. It doesn't go so far as to say the amyloid angle is bunk, does it? Your second link says this: > researchers have said experimental treatments targeting the beta amyloid protein might not have worked in the past because the doses were too low or the patient popul…

> I can't get the whole paper, but your first link seems to be saying that we've put all our eggs into one basket and we are ignoring too many other theories. It doesn't go so far as to say the amyloid angle is bunk, does it?

Check sci-hub: https://sci-hub.hkvisa.net/10.1016/j.bcp.2018.09.027

Quote:

> Furthermore, the blind adherence to the “Amyloid code” [297] has resulted in the overwhelming rationalization of clinical trial failures - the lack of validation of the amyloid hypothesis – as being due to recurring issues in their planning and execution, not that the hypothesis has failed in its validation. This viewpoint, described as “sheer obstinacy in the face of compelling proof ..[of being]… on the wrong track” [285] has also compromised the translational approach to AD therapeutics making the criteria for compound advancement from preclinical research to the clinic exclusively based on either a blind faith in a hypothesis or animal models that have proven irrelevant.

This addresses the special pleading you quoted from people who continue trying to explain away the failures of the amyloid model.

The writing is on the wall, but as they say, "science advances one funeral at a time".

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#127

Post by mirekrusin »

light_hue_1 wrote: post #84

Another horrific failure of reviewers. 6 subjects!? Did anyone actually check the study they registered? https://clinicaltrials.gov/ct2/show/NCT02790541 Their actual clinical trial had 62 subjects and it had a control arm. The paper has only 6 subjects and no controls. If I run an experiment with 60 people, I can find evidence for anything (precognition, telekinesis, etc.) if I'm allowed to cherry pick 6 data points…

Maybe 56 died?

Re: Hyperbaric oxygen therapy reverses hallmarks of Alzheimer’s disease and dementia

#128

Post by robbiep »

naasking wrote: post #125
robbiep wrote: post #118

Earlier quoted context omitted.

which does nothing to explain why people with APP mutations such as found in fAd develop early onset Alzheimers. So the mystery of Amyloid and its role in dementias persists

The simplest explanation is that APP mutations cause some other dysfunctions which then causes Alzheimer's. It's these other dysfunctions we should be looking for.

We still haven’t proven that amyloid plaques don’t have at least some level of responsibility. Just because we now have the ability to clear plaques, and it hasn’t lead to improvement, doesn’t prove that amyloid plaques aren’t involved in disease progression.

Now let me be clear, I’m not a cheerleader for any of them. I have read every original paper on the pathophysiology of AD from the 60s through to 2014 and I saw in detail the debate bounce back and forth from Amyloid to Tau with sprinkles of ‘Type 3 diabetes’ and inflammation and back again like a game of tennis. The science will come out the way it will come out.

But there is nothing about our ability to remove plaques with no change in the disease that says that amyloid plaques don’t have a role in disease pathogenesis. Could be the damage is done and clearing them is irrelevant. We just don’t know enough

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