Earlier quoted context omitted.
Is Wikipedia wrong? They say this: > Alzheimer's disease is believed to occur when abnormal amounts of amyloid beta, accumulating extracellularly as amyloid plaques, and tau proteins, accumulating intracellularly as neurofibrillary tangles, form in the brain affecting neuronal functioning and connectivity, resulting in a progressive loss of brain function.
Wikipedia is correct to say it's widely believed that plaques cause Alzheimer's, because the new evidence is still encountering resistance. The hallmark of science is falsification. We now have many drugs that remove amyloid plaques with few side effects. Removing plaques does not improve symptoms or halt progression [1, 2]. Furthermore, 60% people over 80 have these plaques but only 10% develop dementia [3]. Ergo, t…
Your second link says this:
> researchers have said experimental treatments targeting the beta amyloid protein might not have worked in the past because the doses were too low or the patient populations used for the trials should have been younger
Again, that doesn't seem to be concluding the amyloid & tau street is a dead end.
The Alzheimer's Association site (alz.org) agrees:
> Alzheimer's has no cure, but one treatment — aducanumab (Aduhelm™) — is the first therapy to demonstrate that removing amyloid, one of the hallmarks of Alzheimer’s disease, from the brain is reasonably likely to reduce cognitive and functional decline in people living with early Alzheimer’s.