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Israel’s Covid-19 boosters are preventing infections, new studies suggest

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Re: Israel’s Covid-19 boosters are preventing infections, new studies suggest

#331

Post by Grakel »

sjg007 wrote: post #325
Grakel wrote: post #318

Earlier quoted context omitted.

The government does not have rights. In the United States the power resides in the individual citizens. The "government" are individual citizens selected to do the paperwork. When their corruption exceeds our disinterest, they're done.

Umm.. this is why we need civics classes because people Don’t actually understand what the purpose of government is and what we rights we give up to be governed.

We do need much better civics and history classes. We don't "give up rights," and we're not "governed" in this country. Look at the wording of the bill of rights. It's a list of limits on the government.

Re: Israel’s Covid-19 boosters are preventing infections, new studies suggest

#332

Post by evilpotatoes »

inglor_cz wrote: post #198
heavyset_go wrote: post #112

Earlier quoted context omitted.

> Humans do not get permanent antibodies from the vaccines. They get antibodies from getting infected. Weird, I've yet to get chicken pox/shingles, mumps, polio etc despite being vaccinated against them as a child. And I still catch the flu regularly despite having already had it.

Not the OP, but antibodies are just one part of a fairly complex immune system and it does not make too much sense to concentrate just on them. Antibodies are proteins and their level goes down over time naturally. What really interests you is the level of immune response on subsequent exposure to the pathogen, which may be pretty robust even if antibodies are low or undetectable at the moment of new exposure. We obv…

https://www.medrxiv.org/content/10.1101/2021.04.19.21255739v... https://www.medrxiv.org/content/10.1101/2021.08.24.21262415v... <-- 6x better than fresh vaccine after a year or so, 13x better in a 4-6 month period after

Re: Israel’s Covid-19 boosters are preventing infections, new studies suggest

#333

Post by dogma1138 »

Vecr wrote: post #275
dogma1138 wrote: post #264

Earlier quoted context omitted.

No, it doesn’t work like that mRNA isn’t a virus or virus like it doesn’t hijacks the cell. The mRNA fragments are picked up by dendritic cells and antigens are produced. The antigens (and the mRNA itself) are then attacked by special proteins within your cells that are designed to destroy foreign or malformed proteins and the fragments of those destroyed antigens are then presented in the cell membrane for T and B c…

What about cytotoxic T cells? What would prevent them from killing the cell?

By the time you have a T Cell response the mRNA and the antigens would be long gone.

Re: Israel’s Covid-19 boosters are preventing infections, new studies suggest

#334

Post by MatteoFrigo »

quantumwoke wrote: post #327
MatteoFrigo wrote: post #322

Earlier quoted context omitted.

Slide 11 appears to say that a large number of cases were hospitalized. If this interpretation is correct, we are talking about a diagnosis from a doctor, not self-reported data.

All the slides say is that there were 700ish reports that met case criteria as reported through VAERS, a self-reporting system. We are not told any information about which case criteria were met (objective vs subjective), comorbidities, reason for presentation (all vital information for a true diagnosis not report ). We are not told about degree of hospitalisation or reason for hospitalisation. We are most certainly…

Does the link https://www.cdc.gov/mmwr/volumes/70/wr/pdfs/mm7027e2-H.pdf on the same page 11 answer your concerns? That paper (from June) explains in some details what the CDC did, and I would assume that the slides are just an update of the numbers on the paper to a later date. At least the author of the slides was an author of the paper, so I would infer that they kept doing whatever they were doing in June.

One thing that the paper is pretty clear about is that in order to proclaim a "case", the CDC reviewed medical records and interviewed the healthcare provider looking for specific criteria. It seems like all criteria include at least one test, e.g. EKG, in addition to symptoms reported by the patient. It's not like they ran a SQL query over a bunch of dudes reporting chest pain---the CDC did their homework. If anything, I have more confidence in the CDC and the vaccines now than I had before reading these documents.

Re: Israel’s Covid-19 boosters are preventing infections, new studies suggest

#335

Post by dukeofdoom »

disgruntledphd2 wrote: post #312
ac2u wrote: post #295

Earlier quoted context omitted.

>natural immunity, which it turns out is superior and much more longer lasting anyway where are you getting this from?

I don't know, but lots of people seem to claim this (without citations).

"This study demonstrated that natural immunity confers longer lasting and stronger protection against infection"

https://www.medrxiv.org/content/10.1101/2021.08.24.21262415v...

Re: Israel’s Covid-19 boosters are preventing infections, new studies suggest

#336

Post by sjg007 »

Grakel wrote: post #331
sjg007 wrote: post #325

Earlier quoted context omitted.

Umm.. this is why we need civics classes because people Don’t actually understand what the purpose of government is and what we rights we give up to be governed.

We do need much better civics and history classes. We don't "give up rights," and we're not "governed" in this country. Look at the wording of the bill of rights. It's a list of limits on the government.

I think the Supreme Court disagrees with you. https://www.latimes.com/opinion/story/2020-04-20/government-...

Re: Israel’s Covid-19 boosters are preventing infections, new studies suggest

#337

Post by leoedin »

gilbetron wrote: post #313
leoedin wrote: post #307

Earlier quoted context omitted.

The risk of hospitalisation for most people who get covid is way higher than 0.01% - it's about 1% for a 21 year old man, 2.7% for a 30 year old man and 8.5% for a 50 year old man - and only goes up from there. https://www.economist.com/graphic-detail/covid-pandemic-mort...

I should've posted where I got the values for Covid risk, my bad. I used this: https://qcovid.org/Calculation and did it for a healthy 25 year old, and then rounded. I don't know exactly what the different between what I used and what the Economist used, but I'm guessing the Economist is using a dataset of people that skewed more symptomatic?

I wrote more in another comment - https://news.ycombinator.com/item?id=28391526

Basically the qcovid calculator tells you the overall risk during a specific period of the pandemic . Most people didn't get covid during that period, which makes the overall risk appear very low.

However, if you do contract covid (which seems inevitable if it becomes endemic) then the individual risk of hospitalisation is much higher - 1%+ for even young adults.

Re: Israel’s Covid-19 boosters are preventing infections, new studies suggest

#338

Post by Vecr »

dogma1138 wrote: post #333
Vecr wrote: post #275

Earlier quoted context omitted.

What about cytotoxic T cells? What would prevent them from killing the cell?

By the time you have a T Cell response the mRNA and the antigens would be long gone.

Not if it's a booster, or even the second dose. That's the whole idea of this chain, yeah?

Re: Israel’s Covid-19 boosters are preventing infections, new studies suggest

#339

Post by dang »

vkou wrote: post #10

> Probably better to focus on the minimum number of vaccinations necessary to make hospitalization/death unlikely and move on from there. It would be nice if we could meet even that bar, but the US is currently at 53% of the population vaccinated, and much of its medical system is collapsing. Which is fine for that 53%, until they have a heart attack, get in a car accident, cancer, are immuno-compromised, etc, etc. G…

We detached this subthread from https://news.ycombinator.com/item?id=28381401.

Re: Israel’s Covid-19 boosters are preventing infections, new studies suggest

#340

Post by floxy »

Izkata wrote: post #153
hackingforfun wrote: post #73

I'm pretty surprised to still see some misinformation in some of the posts here. I have a friend who has a PhD in molecular biology and she described the mRNA vaccines to me. The mRNA is only a piece of the spike protein, and does not enter the cell's nucleus. It only interacts with the cytoplasm. Normally, if a cell had to deal with an actual SARS-CoV-2 virus, it would be dealing with the spike proteins and the enti…

> Look at the states with the highest amount of unvaccinated individuals in the US. They are running out of hospital beds [1]. This is not about taking our freedoms, this is about getting this under control. > [1] https://fortune.com/2021/08/25/states-icu-beds-covid-cases-d ... I can't see the article due to paywall, but based on how you're presenting I have to say: Due to the phrasing it isn't a straight lie, but it…

Interestingly enough, in Idaho, 92.3% of people over 65 have at least one dose.

https://www.mayoclinic.org/coronavirus-covid-19/vaccine-trac...

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