I've tried every psy except Ayahuasca: DMT, LSD, Bromo-DragonFLY, RC's from the 2c family, ketamine, MDMA, and so on. In each case, I had "profound" realizations during the experience that lasted a day or two, then I reverted back to my normal ways of being depressed in a messy apartment and slacking at my job. In this article, I see descriptors of Ayahuasca similar to those of other psychedelics (years of therapy in…
From what friends have described, it is very different. I’ve seen it transform a number of lives, including one guy who started out with a single visit to Peru to do it and the decided to live there permenantly. I think context matters as well — these people were all doing it as a group to accomplish something with a shaman, and not just for fun at a rave or whatever.
source: psy-friendly people who have been there