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Having SARS-CoV-2 once confers much greater immunity than a vaccine

sciencemag.org

81–90 of 371 posts

Re: Having SARS-CoV-2 once confers much greater immunity than a vaccine

#81
Those who think this is supporting evidence for not getting vaccinated should think it again.

You must think in terms of risk of hospitalization and/or long covid with or without vaccination over the course of the whole path you choose.

ps. Moderna seems to be much more effective against Delta than Pfizer-BioNTech.

Re: Having SARS-CoV-2 once confers much greater immunity than a vaccine

#82

Why is "natural infections and recovery produce a better immune response than a vaccine" so controversial? Has it been this controversial for any other disease?

> Why is "natural infections and recovery produce a better immune response than a vaccine" so controversial? Has it been this controversial for any other disease?

Confirmation bias

Re: Having SARS-CoV-2 once confers much greater immunity than a vaccine

#83
I got downvoted for saying this here a while back. Anyone with good immunology experience would guess this to be accurate no matter what some half baked study says (which was what a bunch of people were telling in that earlier thread). Again doesn’t mean you should go get Covid or avoid the vaccine. The vaccine only helps. If you got Covid and then also got the vaccine it only helps more.

Re: Having SARS-CoV-2 once confers much greater immunity than a vaccine

#84

I can only consider this a positive for those who are vaccine hesitant, as they will probably be getting it, but I can't see how, considering the realistic dangers of a vaccine, a rational individual wouldn't want both forms of protection even if they were previously infected.

Consider the realistic uncertainty and probability from previous study of antibody dependent enhancement. It’s not proven that the mRNA therapy won’t worsen covid reaction in the long run.

> It’s not proven that the mRNA therapy won’t worsen covid reaction in the long run.

What are you defining by "long run"? We're quickly moving into a year with mRNA therapies. I'm not aware of any instance of this occurring with previous vaccines, and we can't just say "well mRNA could be different" because if we do that all the possible "what-ifs" we quickly swing into the absurd.

Re: Having SARS-CoV-2 once confers much greater immunity than a vaccine

#85
This feels like an irresponsible title on behalf of the author. People don’t get the vaccine strictly on the strength of the vaccine. It’s considering the risk of getting COVID, understanding the long term side effects, and minimizing risk for those around you. It’s also about avoiding mutations of the virus as the higher availability of the virus only provides more opportunities for it to mutate into something more resistant or possessing other less desirable traits. I understand that the post goes into these types of details but with the proliferation of “I read the title so I read the article” types a much less clickbait title should have been chosen. This only vindicates people looking to confirm their biases and leaves out the nuance that is so important to science.

Re: Having SARS-CoV-2 once confers much greater immunity than a vaccine

#87

The Lancet just published a study yesterday on natural infection still causing symptoms one year later (“long Covid”) for 49% of unvaccinated people. I’ll stick to the vaccine.

The study you're probably talking about focuses on hospital survivors, not on the broad group of "naturally infected people".

Re: Having SARS-CoV-2 once confers much greater immunity than a vaccine

#88
post #12

>the risk of developing symptomatic COVID-19 was 27 times higher among the vaccinated, and the risk of hospitalization eight times higher This sounds convincing, but then in the next graf: >For instance, the higher hospitalization rate in the 32,000-person analysis was based on just eight hospitalizations in a vaccinated group and one in a previously infected group. And the 13-fold increased risk of infection in the…

To develop natural immunity, you would need to get infected with the virus, no? That's considerably more risky than getting the vaccine. If you do get infected with the virus after vaccination, wouldn't you also develop natural immunity?

If you got Covid before vaccines were available that risk assessment is irrelevant.

If you get COVID after vaccination, your immune system may not learn how to fight COVID-19 as well, because the vaccine is present and doing something.

Re: Having SARS-CoV-2 once confers much greater immunity than a vaccine

#89

The term ”survivor bias” is usually used metaphorically, but in this case it applies literally. Putting in some caveats about the risks associated with infection is not enough. This is a garbage analysis that should never have been accepted for publication.

I don't see survivor bias here at all. This is simply a study that caters to a rather significant population who justifiably want to know what they stand to gain from this vaccine.

What this study has done is identified a sub population who stand to gain such minuscule benefit from vaccination that it would be unethical to include them in a study (most studies DO exclude previously infected individuals, huh wonder why?) Furthermore it is unscientific discrimination to penalize people when they could prove prior infection and/or immunity.

Re: Having SARS-CoV-2 once confers much greater immunity than a vaccine

#90
Tasteless/careless, IMO, especially living (in Texas) where “covid parties” have happened and people lost their lives right around the block last year. Although, it may be of relevance to my younger unvaccinated nephew that survived a rough case last December and is worried about being in school over in Tennessee without masks.
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