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Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

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Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#251

Post by CountDrewku »

Ensorceled wrote: post #202
CountDrewku wrote: post #197

Earlier quoted context omitted.

>The "probably climate change" is supposition, hence the "probably" Then maybe just leave it out next time. I'm tired of people claiming climate change is responsible with no data to back it up for every natural event. That's no better than someone claiming global warming doesn't exist because they have a cold week of snow.

> Then maybe just leave it out next time. No, I won't, because it is probably climate change.

Weird you still have no data showing that so me saying it probably ISN'T climate change hold every bit as much truth as you writing it.

So sure leave it in, just know you're at the same level as a climate change denier.

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#252

Post by CountDrewku »

jannyfer wrote: post #220
CountDrewku wrote: post #197

Earlier quoted context omitted.

>The "probably climate change" is supposition, hence the "probably" Then maybe just leave it out next time. I'm tired of people claiming climate change is responsible with no data to back it up for every natural event. That's no better than someone claiming global warming doesn't exist because they have a cold week of snow.

https://www.ctvnews.ca/climate-and-environment/ticks-spreadi... https://www.canada.ca/en/public-health/services/reports-publ... Here are a few sources with two mins of Googling.

The discussion does not involve you, so kindy butt out. I asked the OP a question not you.

Burden of proof is on the commenter. They did not provide proof. The burden is not on me to Google anything when someone else spouts a claim.

Your first article is literally just a guy saying it has changed with nothing to back it up.

From the second study which I'm guessing you haven't even read-

"Climate and other environmental changes are expected to increase the risk of ticks and TBDs in a number of ways."

"Prolonged extremes values of temperature (high or low), low humidity and intense rainfall could adversely affect tick development by reducing their activity and increasing their mortality rateFootnote 5. These changes in temperature are expected to have less of an effect on ticks than on mosquitoes because of the tick’s ability to find refuge in their woodland habitats"

"It is important to note, however, that the relationship between tick-borne diseases and climate is not linear."

Notice the key words EXPECTED and ANTICIPATED.

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#253

Post by andrekandre »

ad404b8a372f2b9 wrote: post #239
andrekandre wrote: post #224

Earlier quoted context omitted.

got any links about this?

What do you mean? That's some of my sister's symptoms.

id like to read up on it, if there were any articles etc i was thinking it would be great to reference (for myself) since ive been googling and haven't really found anything much...

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#254

Post by _Microft »

ethbr0 wrote: post #149
_Microft wrote: post #128

Earlier quoted context omitted.

The mRNA is hidden inside lipid nano-droplets. These droplets merge with cells and the mRNA gets released into them. From what I understand, pure mRNA would be broken down if it ended up in the interstitium (fluid filled space between cells) without being hidden inside this lipid shell. The sequence is also slightly altered compared to original one to make it more stable and less likely to produce an immune response…

Lipid nanoparticles, and the research done around their ability to serve as transport and safety, are the real technological breakthrough here. Not to say the mRNA technology isn't amazing, but if we had it but no LNPs, we'd have a whole lot of nothing.

You might be interested in this article. It is about a biochemist who invented the way to prepare these nanoparticles but was cheated out of his share of the fame and money.

https://www.forbes.com/sites/nathanvardi/2021/08/17/covids-f...

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#255

Post by darkerside »

ad404b8a372f2b9 wrote: post #129
darkerside wrote: post #99

Earlier quoted context omitted.

What gives you so much confidence it was the vaccine? Correlation does not equal causation, as we all know around here.

I'm not confident one way or another. But I'm not ready to take this story at face value as a sad story of a vaccine being recalled because of a few loud-mouthed anti-science idiots just because "no causal-link was established by the FDA". Health-policy and politics in general have a perverse effect on the science. What was the official stance of the government one day becomes misinformation the next, and vice-versa.…

I don't disagree with the principle behind what you say. But the application to where you are acting under the assumption that Pfizer caused your sister's side effects seems unwarranted. It's certainly worth investigating, but it is far from a certainty.

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#256

Post by darkerside »

f6v wrote: post #101
darkerside wrote: post #90

Earlier quoted context omitted.

Why not both?

Because pharma companies don’t work for the public, but for the shareholders.

And if they are first to develop a new Delta specific vaccine, they will be making their shareholders money hand over fist

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#257

Post by darkerside »

CountDrewku wrote: post #161
darkerside wrote: post #120

Earlier quoted context omitted.

Can you share what kind of evidence is typically cherry picked or ignored in service of that conclusion? Genuinely curious. If the infection does have that mechanism, would that invalidate the idea that a vaccine would be at all helpful?

Not sure if there's evidence for that but it's much more likely to be the case. There's no solid evidence "chronic lyme" exists either. The only "doctor's" you'll see treating it are typically into the naturopathic stuff and all other sorts of unproven treatments for things the medical community doesn't even agree exist.

It's funny how it sometimes happens that the scientific or medical community makes a decision. I'm not quite sure how it happens, but once it's done, you need an overwhelming amount of evidence to overturn it. Much more than if the decision had never been made in the first place.

Who makes these decisions, and on what grounds? I honestly don't know.

Edit: But my theory is that it's based on informal groupthink.

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#258

Post by darkerside »

M2Ys4U wrote: post #205
darkerside wrote: post #105

I wonder if this might be effective as a treatment for chronic Lyme sufferers as well as a preventative measure.

"chronic lyme disease" doesn't exist, so probably not...

PTLDS then

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#259

Post by murgleburgle »

f6v wrote: post #93
honksillet wrote: post #28

Earlier quoted context omitted.

Does anyone know why they haven't released a Delta varient vaccine? Is seems that it would just involved we changing the mRNA sequence in a computer at the factor, but I'm really just guessing. Also maybe it is considered a whole new vaccineand needs to go through approval again.

I’ve read somewhere that they don’t just take a sequence. There’re some tweaks they make to produce effective immune response. CureVac failed to produce a good vaccine for this reason. My take is that mRNA technology is being overhyped, although it’s a massive step up over other approaches.

CureVac probably failed because they used unmodified RNA base pairs. Both Moderna and BioNTech/Pfizer use modified nucleosides such as N1-methyl-pseudouridine. Extracellular unmodified mRNA - which could arise from the lipid nanoparticles which contain the mRNA breaking down before transfection of cells - can trigger a deleterious innate immune reaction against said mRNA. This interferes with the desired immune recognition of the spike protein. The modified mRNA largely evades that undesired immune reaction. That's probably what sunk CureVac's vaccine.

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#260

Post by thatcat »

littlestymaar wrote: post #103
thatcat wrote: post #27

Earlier quoted context omitted.

Though it's not available in the US.

From the Wikipedia article about that disease [1] it seams the disease isn't prevent in the US, so it wouldn't make sense to get vaccinated against it there (like European people who aren't vaccinated against yellow fever by default). [1]: https://en.wikipedia.org/wiki/Tick-borne_encephalitis

Lyme disease is not the same as tick-borne encephalitis. Lymerix was a vaccine approved by FDA in US in 1998 because lyme is pretty common in Appalachia, but it was taken off the market. Dogs are recommended to receive a lyme vaccine here, but it's not available to people.
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