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Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

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Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#201

Post by incrudible »

harshreality wrote: post #175
dolni wrote: post #146

Earlier quoted context omitted.

You're making the incorrect assumption that catching some new, dangerous strain of COVID is a guarantee. It isn't. Pushing out a vaccine that causes harm, even if it's substantially less than the virus it protects against, is asking for a lot of trouble.

Consider two ratios: Harm ratio = harm caused by vaccine / harm caused by virus Exposure ratio = projected people who would be infected by the virus / projected people who would take the vaccine In an airborne, high-R_0 pandemic situation, the exposure ratio is high enough that only one of two cases apply: 1) The potential health problems caused by small-scale exposure to the spike protein alone is relatively small c…

The potential health problems are unknown. For example, we are assuming that Myocarditis/Pericarditis is extremely rare, or at least more rare than in a viral infection. Do we really know that, for all age groups and all vaccines? I have doubts, we are still in the discovery phase:

https://www.reuters.com/world/us/us-probing-moderna-vaccine-...

The spike protein is not necessarily a problem, but both NLP and viral vectors have never been rolled at the current scale. TTS seems to be particular to viral vectors, Myocarditis/Pericarditis more so to NLP.

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#202

Post by Ensorceled »

CountDrewku wrote: post #197
Ensorceled wrote: post #170

Earlier quoted context omitted.

Which part do want proof of? Google "ticks in ontario increasing" for literally dozens of references. The "probably climate change" is supposition, hence the "probably" disclaimer, but a lot of those references above blame "milder winters" or climate change directly.

>The "probably climate change" is supposition, hence the "probably" Then maybe just leave it out next time. I'm tired of people claiming climate change is responsible with no data to back it up for every natural event. That's no better than someone claiming global warming doesn't exist because they have a cold week of snow.

> Then maybe just leave it out next time.

No, I won't, because it is probably climate change.

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#203

Post by myko »

pfdietz wrote: post #131
swalsh wrote: post #51

Earlier quoted context omitted.

I think our approval processes haven't kept up with the technology. The existing vaccine is already approved, and boosters seem to have some beneficial affects.

If the GOP weren't so foolish against vaccines, they could have made hay criticizing the slowness of the FDA.

Being foolish against vaccines hasn't stopped conservative media from criticizing the speed of the FDA:

https://twitter.com/RadioFreeTom/status/1429946530782498818

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#204

Post by munchbunny »

desine wrote: post #104
kadoban wrote: post #66

Earlier quoted context omitted.

A desire to avoid being called anti-vax.

Out of curiosity, if you're onboard with previous typical vaccination, but hesitant to jump on board with mRNA treatments, what are you? Does that now fall under "anti-vax" in internet lingo? Is wise to group everyone under one umbrella term?

That depends on why they're hesitant about mRNA vaccines. The "anti-vax" label isn't just about not taking some subset of the standard vaccinations. There's a tribal element and a conspiracy/disinformation element.

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#206

Post by lwn »

jmnicolas wrote: post #126
inglor_cz wrote: post #71

Earlier quoted context omitted.

Ticks don't fly and they generally dislike sunlit or dry places. They will mostly lurk in darker, wetter places, up to 3 feet from the ground. So a shady tree patch with overgrown grass at the edge of a swamp or creek is much more likely to be thoroughly infested than other places. Use a repelent, wear some light-colored clothes to spot a crawling tick easily, tuck the (long!) trousers into your hiking shoes and you…

> Use a repelent AFAIK permethrin is the only available repellent for ticks but please be aware that it provokes blindness in cats.

'Deet' is also available as repellent against ticks, although less effective. Permethrin is (also) extremely toxic to fish and aquatic life.

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#207

Post by M2Ys4U »

exhilaration wrote: post #196
Thaxll wrote: post #7

Why is it a vaccine? Are there going to be vaccine for everything in the future?

Imagine a vaccine against various cancers!

Cancer is exactly why we vaccinate against HPV, as it's a huge cause of cervical cancer.

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#208

Post by ghaff »

Gupie wrote: post #199

How effective would such a vaccine need to be? A vaccine of say 70% might be effective enough for herd immunity for a disease that is contagious person to person. But you don't get Lyme disease from other people so herd immunity is not possible, unless the intention is to inoculate deer, (no pun intended).

As a benchmark, the dengue fever vaccine (Dengvaxia) is about 60-70% effective and is very effective at suppressing the worst symptoms, but may actually put the person being vaccinated under more risk of serious symptoms if they've never had Dengue before and manage to catch it anyway post-vax. Dengue is an unusual disease in that, to simplify somewhat--there are actually 4 strains--catching Dengue a second time can be much more serious than the first time.

Anyway, between the effectiveness, possible side effects, and the aforementioned risk, it's not considered a great vaccine and it's authorized for fairly limited use in the US.

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#209

Post by Elinvynia »

foxhop wrote: post #194

About 8 weeks ago I was bitten by a tick and contracted Lyme Disease and I put my story up on YouTube to try to help others, let's just say it's a crazy ride downhill if you neglect the bacterial infection: https://youtu.be/xbPr7DHwSIw In the video I talk about the treatment I followed to recover. Today symptoms appear gone but there have been testimony of hidden, lingering, or reoccurring issues after infection. All…

Why don't you fully trust mRNA vaccines?

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#210

Post by foxhop »

wil421 wrote: post #138
nyolfen wrote: post #117

Earlier quoted context omitted.

> At the beginning of the pandemic, people theorized that public health will influence future media for a generation, much like WW2 did. For decades, we got war TV shows, war movies, war comics, etc. Hogan's Heroes ran into the '70s, Sgt. Rock was published until the late '80s, and so on. And I think we're about to see the same with media based on public health efforts. but we actually won that war, which precipitate…

WW2 had the Red Scare, Japanese interment camps, and shocking amounts of human experimentation. I would like to hear about the fear mongering and downright lies that were going on during WW2 from someone who was there. I’d bet there was lots of misinformation going around, social media has made those types of things flourish. If you look back at history through rose-tinted glasses everything will appear better than i…

Especially once it stops being about race when we say we need to investigate how humans used the Scienctific process took "a solution in search of a problem" and collected samples laboratories, like searching for a needle in a haystack in Wuhan to purposefully replicate and infect chimeric rat/humans with bat viruses. Whether maliciously or not that is the likely prevailing Truth on why we now have a 5th corona virus we need to guide toward an endemic state.

I'm obviously not happy with the state of the world as a computer scientists.

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