Live data from Hacker News

Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

pfizer.com

221–230 of 271 posts

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#221
post #140

Earlier quoted context omitted.

One reason is because they've found that simply boosting with the original mRNA gives a massive spike in protection even against Delta, apparently on par with variant specific versions of the vaccine. Another is that recent studies are showing that natural infection provides much more comprehensive, long-lasting immunity against all variants than the vaccination does, while vaccination with the current vaccines offer…

I haven't seen any research that says that infection acquired immunity is stronger or longer lasting than from vaccine. The opposite in fact.

There's been some mixed signals coming out of the research, but that's in part due to how immunity is being measured. There are definitely some studies showing that particular antibody levels for vaccines can be higher or longer lasting than natural infection, but recent research is showing that those with natural infection have had a far smaller risk of reinfection than those vaccinated, even when controlling for comorbidities. There are still confounding factors, such as behavioral differences between the groups, but its a pretty stark difference. It also makes sense from a theoretical standpoint, as acquired immunity is based on more than the just spike protein, unlike the vaccines, which is a big part of the differences between variants like Delta. The thought is that natural immunity is therefore more resilient to changes between variants.

Its all early enough that its still an open question, but there's definitely early evidence that natural immunity is more resilient than vaccination only.

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#222

Earlier quoted context omitted.

One bad autoimmune reaction from a poorly engineered vaccine and the whole society will boycott the mRNA vaccines forever after. Safety is higher priority to ongoing viability than speed.

But it doesn't make sense in this context. They're literally changing nothing except the mRNA sequence. If a new vaccine is made by taking a gene sequence from a virus protein that's already in the wild, and packaging it into a delivery mechanism (LNP) that's already approved for another vaccine... If there are any strange reactions to the new spike protein, that would also be caused by the wild virus spike protein,…

> They're literally changing nothing except the mRNA sequence.

This is like comparing my house to the Willis Tower and saying, "they're literally changing nothing except the blueprints."

mRNA codes for proteins. Coding for a different protein will produce different effects in the body. Most will probably be harmless. If a vaccine codes for a protein too similar to proteins that already exist, that vaccine will produce autoimmune disease.

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#223
post #11
post #7

Why is it a vaccine? Are there going to be vaccine for everything in the future?

Vaccines are a very good way to prevent serious disease and may make it possible to eradicate diseases. The best medical treatment is the one you never have to do.

A vaccine is a medical treatment.

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#224
post #59

Earlier quoted context omitted.

Curious - what currently unrecognized side-effects are we talking about here?

Multiple oedemas and the appearance of enlarged veins far away from where the vaccine was injected.

got any links about this?

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#225
post #216

Earlier quoted context omitted.

What's the point in differentiating? They at best deluded themselves with a slightly different brand of anti-vax propaganda. Do we need a separate term?

So there's no possible valid logic for not wanting an mRNA vaccine. It's all completely "delusion" stemming from propaganda? Anyone who does not have complete faith at this point is in the wrong? Am I understanding you correctly?

There are no general reasons to avoid well tested mRNA vaccines, no.

Specific medical conditions (eg allergies to components of the shot), being under the recommeded/tested ages, etc., sure.

I unfortunately know several anti-vaxxers, I've seen what they pass around as "reasons". It's nonsense. And it just so happens that they all get their news from similar places. It's a total coincidence I'm sure.

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#226
post #134

Earlier quoted context omitted.

Yes, of course, but you then appeared to query the "unfounded" nature of the claims. I thought you had missed the part where they turned out to be indeed unfounded.

You should assume the strongest interpretation of the comments you reply to, it leads to better conversations and is part of the site's guidelines. I disagree about the fact that they're unfounded having read the comment I replied to, therefore it follows I do not believe the results of the FDA's investigation are conclusive. I illustrate this with the Hep-B vaccine for which the health-autorities have not found a ca…

Wait. You quoting the site's guidelines because the poster assumed you were questioning the unfounded claim but now you are stating you disagree with the unfounded claim?

I'm confused. Can you clarify you stance here?

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#227
post #7

Why is it a vaccine? Are there going to be vaccine for everything in the future?

Imagine a vaccine against various cancers!

No need to imagine, HPV infection causes cervical, vulva, vagina, penis, anus, and oropharynx cancer and we have a vaccine for HPV (that is effective against the majority of the strains of HPV that cause cancer)! According to the CDC "almost all cervical cancer can be prevented by HPV vaccination."

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#228

Earlier quoted context omitted.

Not a totally novel virus. The reason why vaccines were developed within days of isolating the virus is because SARS-COV-2 is not that different from SARS-COV-1 and all the vaccine research efforts carried over. What was pathetic was the federal coordination - hesitation on travel restrictions, CDC response, recommendations against PPE… Lessons that could have been learned even from the 1918 pandemic were painfully i…

It's not surprising when you look at who was running the federal government at the time. If it wasn't a shitshow, there would have been something wrong in the universe.

I don’t think anyone “runs” the federal government. I think offices and processes exist, and I think there’s a semi-hereditary politburo occupying said offices, but I don’t think anyone has much authority.

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#229
post #207

Earlier quoted context omitted.

Imagine a vaccine against various cancers!

Cancer is exactly why we vaccinate against HPV, as it's a huge cause of cervical cancer.

HPV also causes vulva, vagina, penis, anus, and oropharynx cancers as well.

https://www.cdc.gov/cancer/hpv/basic_info/cancers.htm

>In general, HPV is thought to be responsible for more than 90% of anal and cervical cancers, about 70% of vaginal and vulvar cancers, and 60% of penile cancers. Cancers in the back of the throat (oropharynx) traditionally have been caused by tobacco and alcohol, but recent studies1 2 3 show that about 60% to 70% of cancers of the oropharynx may be linked to HPV. Many of these may be caused by a combination of tobacco, alcohol, and HPV.

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#230

Earlier quoted context omitted.

Should we have a vaccine for addictions? alcoholism? drug use? eating? Eg: Give it early in people's lives, that the first time they drink even a little alcohol, it should produce such (non life threatening) symptoms - terrible taste, throw up etc, they would not touch it again, and therefore won't be addicted?

I had all those symptoms when I drank my first beer and still learned to love it. You can overcome everything if you really want to.

well, its not a strong enough signal then...
Post reply on HN