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Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

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Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#81

Post by ad404b8a372f2b9 »

jalk wrote: post #59
ad404b8a372f2b9 wrote: post #29

Earlier quoted context omitted.

Unfounded claims from 100s of people developing imaginary autoimmune disorders? Mind you people are still getting compensated in court for autoimmune disorders arising from the Hep-B vaccine, even though no causal link was found. Just yesterday I had to accompany my sister to the phlebologist, because of severe side-effects from Pfizer, he told us he was seeing troves of patients for similar reasons even though offic…

Curious - what currently unrecognized side-effects are we talking about here?

Multiple oedemas and the appearance of enlarged veins far away from where the vaccine was injected.

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#82

Post by Ensorceled »

Thaxll wrote: post #7

Why is it a vaccine? Are there going to be vaccine for everything in the future?

Why wouldn't there be a vaccine? In Ontario, we give children vaccines for diphtheria, tetanus, pertussis, polio, influenza, smallpox (well, I got it as a child), rotavirus, IPD, measles, mumps, rubella, chickenpox, HPV, Hepatitis B, meningococcal disease.

Ticks carrying Lyme disease are exploding in Ontario, probably because of climate change. It makes sense to get this into the rotation as soon as possible.

After COVID, we suddenly have everybody is acting like vaccines are something weird, odd, new and scary.

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#83

Post by corin_ »

mrfusion wrote: post #78

But lyme is a bacteria, not a virus. So there’s not one obvious protein to have the rna produce. What are they making with the rna?

From the article:

> VLA15 is the only active Lyme disease vaccine candidate in clinical development today, and covers six serotypes that are prevalent in North America and Europe. This investigational multivalent protein subunit vaccine targets the outer surface protein A (OspA) of Borrelia, an established mechanism of action for a Lyme disease vaccine. OspA is one of the most dominant surface proteins expressed by the bacteria when present in a tick. VLA15 has demonstrated strong immunogenicity and safety data in pre-clinical and clinical studies so far.

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#85

Post by detaro »

Ensorceled wrote: post #82
Thaxll wrote: post #7

Why is it a vaccine? Are there going to be vaccine for everything in the future?

Why wouldn't there be a vaccine? In Ontario, we give children vaccines for diphtheria, tetanus, pertussis, polio, influenza, smallpox (well, I got it as a child), rotavirus, IPD, measles, mumps, rubella, chickenpox, HPV, Hepatitis B, meningococcal disease. Ticks carrying Lyme disease are exploding in Ontario, probably because of climate change. It makes sense to get this into the rotation as soon as possible. After C…

anthrax is a standard vaccination, really? that one seems kind of surprising.

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#86

Post by Ensorceled »

timonoko wrote: post #39
supperburg wrote: post #20

The first vaccine had a problem where it gave people Lyme every once in a while. My hypothesis is that Lyme disease is an autoimmune disease caused by being exposed too acutely in some way, or for too long. For some people, a tick byte isn’t enough exposure to trigger it. For others, the vaccine is enough. They didn’t catch it early in clinical trials because those people are rare enough to not show up in small studi…

Emphasis should be on tick-bite prevention. I have never had live tick on me and have been literally wallowing on all tick-infested areas on northern hemisphere. They just die. Most probably just drop off, but sometimes there is dead tick only slightly attached. Looks like they die on first drop of blood.

Interestingly, what you described might just be a side effect of tick bite exposure ...

https://www.poughkeepsiejournal.com/story/news/health/lyme-d...

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#87

Post by nverno »

pirate787 wrote: post #64
seren wrote: post #61

This is Phase 2, but I wonder how long Phase 3 will take, given that getting Lyme disease is still pretty rare, can easily be missed or misdiagnosed, it will takes a lot of time and people to get a significant effect between a control group and vaccinated people

Lyme is not rare, the CDC estimates 476,000 cases per year in the US. https://www.cdc.gov/lyme/stats/humancases.html

where I used to live in NH signs posted around trailheads said something like 30% of deer ticks were likely carrying Lyme, and that was 5 years ago.

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#88

Post by Ensorceled »

detaro wrote: post #85
Ensorceled wrote: post #82

Earlier quoted context omitted.

Why wouldn't there be a vaccine? In Ontario, we give children vaccines for diphtheria, tetanus, pertussis, polio, influenza, smallpox (well, I got it as a child), rotavirus, IPD, measles, mumps, rubella, chickenpox, HPV, Hepatitis B, meningococcal disease. Ticks carrying Lyme disease are exploding in Ontario, probably because of climate change. It makes sense to get this into the rotation as soon as possible. After C…

anthrax is a standard vaccination, really? that one seems kind of surprising.

Oops. Started listing all vaccines and then took the response in a different direction. Deleted Anthrax.

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#89

Post by seren »

pirate787 wrote: post #64
seren wrote: post #61

This is Phase 2, but I wonder how long Phase 3 will take, given that getting Lyme disease is still pretty rare, can easily be missed or misdiagnosed, it will takes a lot of time and people to get a significant effect between a control group and vaccinated people

Lyme is not rare, the CDC estimates 476,000 cases per year in the US. https://www.cdc.gov/lyme/stats/humancases.html

Thanks, that is certainly more than I would have expected!

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#90

Post by darkerside »

phreeza wrote: post #34
honksillet wrote: post #28

Earlier quoted context omitted.

Does anyone know why they haven't released a Delta varient vaccine? Is seems that it would just involved we changing the mRNA sequence in a computer at the factor, but I'm really just guessing. Also maybe it is considered a whole new vaccineand needs to go through approval again.

Probably because going through another round of certification is harder than using the existing vaccine as a booster, the hope being that this will already significantly improve delta resistance.

Why not both?
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