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Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

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Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#101
post #34

Earlier quoted context omitted.

Probably because going through another round of certification is harder than using the existing vaccine as a booster, the hope being that this will already significantly improve delta resistance.

Why not both?

Because pharma companies don’t work for the public, but for the shareholders.

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#102

Earlier quoted context omitted.

Does anyone know why they haven't released a Delta varient vaccine? Is seems that it would just involved we changing the mRNA sequence in a computer at the factor, but I'm really just guessing. Also maybe it is considered a whole new vaccineand needs to go through approval again.

There's nothing to update. The mRNA allegedly encodes for the 'spike' protein, which is the infection vector. The theory at the time was that by targeting that protein specifically, if the virus were to mutate, it would loses it's ability to infect because it could no longer successfully bind to the ACE2 receptors. In practice, the efficacy is a fraction of what the trials stated it was. It didn't lose efficacy due t…

Can you back that up?

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#103
post #27

Earlier quoted context omitted.

It's nothing compared to the other tick disease: tick borne encephalitis. Thankfully there's a vaccine against that

Though it's not available in the US.

From the Wikipedia article about that disease [1] it seams the disease isn't prevent in the US, so it wouldn't make sense to get vaccinated against it there (like European people who aren't vaccinated against yellow fever by default).

[1]: https://en.wikipedia.org/wiki/Tick-borne_encephalitis

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#104
post #66

Earlier quoted context omitted.

What makes them not vaccines?

A desire to avoid being called anti-vax.

Out of curiosity, if you're onboard with previous typical vaccination, but hesitant to jump on board with mRNA treatments, what are you? Does that now fall under "anti-vax" in internet lingo? Is wise to group everyone under one umbrella term?

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#106

Prepare to read the headline "mRNA vaccine trial for " a lot in the future. My guess is that they are going to produce mRNA versions of basically any vaccine (and then some) in the future. The nice thing about the technology seems to be that you only need to exchange the mRNA payload while the surrounding delivery method can be reused. That makes it not only a fast method to create a vaccine but a very convenient way…

Does anyone know why they haven't released a Delta varient vaccine? Is seems that it would just involved we changing the mRNA sequence in a computer at the factor, but I'm really just guessing. Also maybe it is considered a whole new vaccineand needs to go through approval again.

Trials of the Delta vaccine have started https://fortune.com/2021/08/09/covid-vaccines-delta-variant-...

IIRC these trials should last 3 months

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#107
post #100

Earlier quoted context omitted.

Safety and speed must usually be balanced in a trade-off, and we are actually used to it, that is why people drive a car, even though it comes with a risk of dying or being maimed. I have no doubt that some kind of safety-related trials must be run on boosters and that they will be run, but they will likely only take weeks in the future, not months.

> but they will likely only take weeks in the future, not months. We need just one Jesse Gelsinger to shut the whole thing down.

J.G. is a famous case and his death definitely delayed development for a decade or more, but it should be noted that when he died, the technology was extremely untested in humans.

We now have a few hundred million people who got mRNA vaccine and had no trouble. I don't think that even after a death, mRNA would be completely toast. It has already proven its merit.

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#108
post #27

Earlier quoted context omitted.

It's nothing compared to the other tick disease: tick borne encephalitis. Thankfully there's a vaccine against that

Though it's not available in the US.

The FDA has licensed a vaccine for tick-borne encephalitis:

https://wwwnc.cdc.gov/travel/diseases/tickborne-encephalitis

The disease appears to be a problem mainly in Europe and Asia, but if you're planning a camping trip in those areas it looks like you can ask a doctor for the vaccine. You also can get the disease from unpasteurized dairy products.

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#109
I assume that mRNA will vaccinate for a lot of diseases, which means that a lot of new viruses will emerge through this evolutionary pressure. It's possible that we are also starting the same race as with antibiotics. Which is still better than people dying from these tiny evil viruses

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#110

Prepare to read the headline "mRNA vaccine trial for " a lot in the future. My guess is that they are going to produce mRNA versions of basically any vaccine (and then some) in the future. The nice thing about the technology seems to be that you only need to exchange the mRNA payload while the surrounding delivery method can be reused. That makes it not only a fast method to create a vaccine but a very convenient way…

that sounds great but its scary technology in wrong hands
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