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Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

pfizer.com

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Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#51

Post by swalsh »

honksillet wrote: post #28
_Microft wrote: post #14

Prepare to read the headline "mRNA vaccine trial for " a lot in the future. My guess is that they are going to produce mRNA versions of basically any vaccine (and then some) in the future. The nice thing about the technology seems to be that you only need to exchange the mRNA payload while the surrounding delivery method can be reused. That makes it not only a fast method to create a vaccine but a very convenient way…

Does anyone know why they haven't released a Delta varient vaccine? Is seems that it would just involved we changing the mRNA sequence in a computer at the factor, but I'm really just guessing. Also maybe it is considered a whole new vaccineand needs to go through approval again.

I think our approval processes haven't kept up with the technology. The existing vaccine is already approved, and boosters seem to have some beneficial affects.

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#52

Post by asah »

ad404b8a372f2b9 wrote: post #29
_Microft wrote: post #8

Earlier quoted context omitted.

There was one but it was taken off the market. It's a bit of a sad story because it worked but because of unfounded claims that it had side effects, it lost trust of the public: "In clinical trials involving more than 10,000 people, the vaccine, called LYMErix, was found to confer protective immunity to Borrelia in 76% of adults and 100% of children with only mild or moderate and transient adverse effects. [...] Subs…

Unfounded claims from 100s of people developing imaginary autoimmune disorders? Mind you people are still getting compensated in court for autoimmune disorders arising from the Hep-B vaccine, even though no causal link was found. Just yesterday I had to accompany my sister to the phlebologist, because of severe side-effects from Pfizer, he told us he was seeing troves of patients for similar reasons even though offic…

I'm sure the FDA is on it, but what about psychosomatic effects?

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#53

Post by _Microft »

pibechorro wrote: post #42
_Microft wrote: post #14

Prepare to read the headline "mRNA vaccine trial for " a lot in the future. My guess is that they are going to produce mRNA versions of basically any vaccine (and then some) in the future. The nice thing about the technology seems to be that you only need to exchange the mRNA payload while the surrounding delivery method can be reused. That makes it not only a fast method to create a vaccine but a very convenient way…

We should not call them vaccines, they work totally different. These are gene treatments.

That's incorrect. They are vaccines even while working differently.

The body develops immunity in reaction to the spike proteins that it produced itself after turning the mRNA instructions contained in the vaccine into proteins (namely the spike proteins that the SARS-Cov2 virus uses to enter cells).

Ribosomes, tiny and amazing molecular machines, read this mRNA and produce the encoded sequence of aminoacids. With every reading, a bit of the tail of the mRNA sequence gets used up and once it's too short, the whole sequence is broken down. That means the mRNA in the vaccine gets used up with time.

The mRNA never makes it into the nucleus where your DNA resides.

Ribosomes are interesting btw, you can read about them here:

https://en.wikipedia.org/wiki/Ribosome

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#55

Post by zz865 »

_Microft wrote: post #14

Prepare to read the headline "mRNA vaccine trial for " a lot in the future. My guess is that they are going to produce mRNA versions of basically any vaccine (and then some) in the future. The nice thing about the technology seems to be that you only need to exchange the mRNA payload while the surrounding delivery method can be reused. That makes it not only a fast method to create a vaccine but a very convenient way…

HIV was a few days ago. Amazing if it works. https://gizmodo.com/moderna-set-to-test-experimental-hiv-mrn...

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#56

Post by inglor_cz »

pibechorro wrote: post #42
_Microft wrote: post #14

Prepare to read the headline "mRNA vaccine trial for " a lot in the future. My guess is that they are going to produce mRNA versions of basically any vaccine (and then some) in the future. The nice thing about the technology seems to be that you only need to exchange the mRNA payload while the surrounding delivery method can be reused. That makes it not only a fast method to create a vaccine but a very convenient way…

We should not call them vaccines, they work totally different. These are gene treatments.

Technically, anything but doctor Jenner's original vaccine against smallpox, which was derived from cowpox, isn't a vaccine. Vacca is literally cow in Latin and vaccine means from cows, which the other vaccines aren't.

But that would be silly, right?

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#57

Post by tpm »

chinathrow wrote: post #45
junon wrote: post #35

Earlier quoted context omitted.

Is that the one that makes you deathly allergic to beef or something?

What joke is this? I am vaccinated against this form of tick born disease but of course I am not allergic to beef.

Not the vaccine. Some ticks now transmit the allergen and cause the allergy in humans:

https://en.wikipedia.org/wiki/Alpha-gal_allergy

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#58

Post by kingkawn »

inglor_cz wrote: post #48
honksillet wrote: post #28

Earlier quoted context omitted.

Does anyone know why they haven't released a Delta varient vaccine? Is seems that it would just involved we changing the mRNA sequence in a computer at the factor, but I'm really just guessing. Also maybe it is considered a whole new vaccineand needs to go through approval again.

Because it means rerunning the trials again. These requirements will have to be loosened for anti-Covid vaccines. They are tailored to other diseases, but SARS-CoV-2 mutates too fast. The flu vaccine has an exception, too, otherwise it wouldn't be possible to prepare the correct vaccine (against the expected dominant strain) on time.

One bad autoimmune reaction from a poorly engineered vaccine and the whole society will boycott the mRNA vaccines forever after. Safety is higher priority to ongoing viability than speed.

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#59

Post by jalk »

ad404b8a372f2b9 wrote: post #29
_Microft wrote: post #8

Earlier quoted context omitted.

There was one but it was taken off the market. It's a bit of a sad story because it worked but because of unfounded claims that it had side effects, it lost trust of the public: "In clinical trials involving more than 10,000 people, the vaccine, called LYMErix, was found to confer protective immunity to Borrelia in 76% of adults and 100% of children with only mild or moderate and transient adverse effects. [...] Subs…

Unfounded claims from 100s of people developing imaginary autoimmune disorders? Mind you people are still getting compensated in court for autoimmune disorders arising from the Hep-B vaccine, even though no causal link was found. Just yesterday I had to accompany my sister to the phlebologist, because of severe side-effects from Pfizer, he told us he was seeing troves of patients for similar reasons even though offic…

Curious - what currently unrecognized side-effects are we talking about here?

Re: Valneva and Pfizer announce Phase 2 study for Lyme disease vaccine candidate

#60

Post by d4rkp4ttern »

mantas wrote: post #21
aixi wrote: post #3

Ever since I moved to the 'first world' I've been scared of this disease. We don't have it where I come from and the long term effects sound straight up terrible.

It's super easy to treat if caught early. But that's where the good ends. Vast majority of cases present the infamous circle. But some don't. And if you got the circle in a hard-to-notice spot, it's easy to miss it (it will a month or two into infection) too. First precaution is to check your legs (and possibly torso/hands) for ticks after passing through high grass. And whole body after coming from the woods. The na…

Should we assume we are safe if we go hiking in a place where we never brushed against any plants or grass or twigs? In other words we went through woods but only stayed on wide open trails. I assume ticks don’t “fly” in the air ?
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