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Longitudinal analysis shows durable immune memory after SARS-CoV-2 infection

cell.com

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Re: Longitudinal analysis shows durable immune memory after SARS-CoV-2 infection

#21

Post by nickthemagicman »

csours wrote: post #3

Just a note to non-immunologists - Immunity means different things to health and science professionals vs the general public. Edit: I'm not going into detail in this comment because I am not an immunologist and I cannot express clearly and correctly what the difference is, but just be aware that "Immunity" may not mean 100% protection in the way that the general public thinks that word means.

As a person with a biology degree who took several immunology courses.

I'd be curious to see what your various definitions are.

Re: Longitudinal analysis shows durable immune memory after SARS-CoV-2 infection

#22

Post by keneda7 »

hprotagonist wrote: post #12
keneda7 wrote: post #10

Earlier quoted context omitted.

Please stop spreading misinformation. IMO 15 weeks is not long enough to determine if its durable and persistent. There would be no talk of booster shots if what your saying is true.

not so, see my other thread in this story here, and cool it on the personal attacks, thanks! https://news.ycombinator.com/item?id=28107714

I updated my comment to make it less personal. Sorry about that

Re: Longitudinal analysis shows durable immune memory after SARS-CoV-2 infection

#23

Post by keneda7 »

JimBlackwood wrote: post #13
keneda7 wrote: post #10

Earlier quoted context omitted.

Please stop spreading misinformation. IMO 15 weeks is not long enough to determine if its durable and persistent. There would be no talk of booster shots if what your saying is true.

Bit of an overreaction. Stating that the testing period of 15 weeks is, in your opinion, too short to determine long-term immunity would’ve sufficed as comment. No need to be uncivil to eachother when you don’t agree.

Updated the comment.

Re: Longitudinal analysis shows durable immune memory after SARS-CoV-2 infection

#24

Post by kfprt »

ajross wrote: post #15
wpasc wrote: post #2

Can any of the findings from the properties of how natural immunity works be guided in to future COVID 19 vaccines? Given how the pharma companies are examining anti-body half life, exploring booster shots, and considering vaccinations against variants (like lambda), can any of the learnings go into a more durable, more broad vaccine?

Vaccine immunity IS "natural" immunity. It works the same way, by exposing the body's immune system to virus components such that they product a response. The only difference is that with a vaccine those components don't add up to a viable organism. But yes: expect newer vaccines tailored to currently-circulating strains to appear; the existing mRNA vaccines produce copies of the spike protein sequenced more than a y…

It's not quite the same, delivery (mechanism/location/encapsulation) is different.

Re: Longitudinal analysis shows durable immune memory after SARS-CoV-2 infection

#25

Post by mxxc »

015a wrote: post #19

Its important to keep studies like this in mind when talking with people who refuse to take the vaccine because they "already had COVID". In a very real sense, if natural antibodies are durable, persistent, and effective; the vaccine is an unnecessary medical procedure. Doctors would not cut off your legs for no reason; that would be unethical. The vaccine is a medical procedure like any other; if the benefit is ques…

it is a scandal, especially considering the amount of non-immunised people at risk in the rest of the world. i fall in that category (recovered) and i would even pay to give my vaccines away.

Re: Longitudinal analysis shows durable immune memory after SARS-CoV-2 infection

#27

Post by orbifold »

hprotagonist wrote: post #6

https://www.nature.com/articles/s41586-021-03738-2 vaccines also produce durable and persistent immune responses. Primary antibody titers wane, but the system itself remembers and can regenerate them when challenged. see https://news.ycombinator.com/item?id=28107714 for contra "but muh boosters", which i suspect is what's helping me collect downvotes.

Not really the anti-body count decays more quickly compared to that of a natural infection and does so dramatically especially for older people: https://www.thelancet.com/journals/lancet/article/PIIS0140-6.... This is the underlying reason that there is talk of boosters.

Re: Longitudinal analysis shows durable immune memory after SARS-CoV-2 infection

#28

Post by JimBlackwood »

ajross wrote: post #15
wpasc wrote: post #2

Can any of the findings from the properties of how natural immunity works be guided in to future COVID 19 vaccines? Given how the pharma companies are examining anti-body half life, exploring booster shots, and considering vaccinations against variants (like lambda), can any of the learnings go into a more durable, more broad vaccine?

Vaccine immunity IS "natural" immunity. It works the same way, by exposing the body's immune system to virus components such that they product a response. The only difference is that with a vaccine those components don't add up to a viable organism. But yes: expect newer vaccines tailored to currently-circulating strains to appear; the existing mRNA vaccines produce copies of the spike protein sequenced more than a y…

Sure, but there is a real difference in response between vaccine/virus.

I think, given the difference in response, the term natural immunity makes sense. You have to choose something and I don’t think ‘natural immunity’ says anything about vaccine immunity being unnatural.

Re: Longitudinal analysis shows durable immune memory after SARS-CoV-2 infection

#29

Post by Hashemm »

mxxc wrote: post #25
015a wrote: post #19

Its important to keep studies like this in mind when talking with people who refuse to take the vaccine because they "already had COVID". In a very real sense, if natural antibodies are durable, persistent, and effective; the vaccine is an unnecessary medical procedure. Doctors would not cut off your legs for no reason; that would be unethical. The vaccine is a medical procedure like any other; if the benefit is ques…

it is a scandal, especially considering the amount of non-immunised people at risk in the rest of the world. i fall in that category (recovered) and i would even pay to give my vaccines away.

Didn't realize anti-vaxxers would be on this site...

Re: Longitudinal analysis shows durable immune memory after SARS-CoV-2 infection

#30

Post by bitexploder »

artursapek wrote: post #16
hprotagonist wrote: post #6

https://www.nature.com/articles/s41586-021-03738-2 vaccines also produce durable and persistent immune responses. Primary antibody titers wane, but the system itself remembers and can regenerate them when challenged. see https://news.ycombinator.com/item?id=28107714 for contra "but muh boosters", which i suspect is what's helping me collect downvotes.

Why are you trolling this thread and shilling vaccines? Does the sight of people discussing the wonder of our natural immune system bother you?

No one is shilling vaccines. We use the "wonder of our natural immune system" effectively with the vaccine without being a public health risk to everyone around us by skipping it.
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