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France issues moratorium on prion research after fatal brain disease strikes

sciencemag.org

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Re: France issues moratorium on prion research after fatal brain disease strikes

#81

The study of rare, contagious diseases seems likely enough to result in an eventual outbreak that it should be treated like enriching uranium. Which is to say, with great caution- and not like regular science but rather like the kind of science with potentially very negative externalities.

CJD isn't contagious, unless you start eating the brain of your friends.

Re: France issues moratorium on prion research after fatal brain disease strikes

#83

The study of rare, contagious diseases seems likely enough to result in an eventual outbreak that it should be treated like enriching uranium. Which is to say, with great caution- and not like regular science but rather like the kind of science with potentially very negative externalities.

this is a nitpick, but "negative externality" isn't a synonym for "bad things happening". It describes a market transaction which inherently imposes costs on an unrelated third party.

For instance, a steel mill producing rolling stock to sell me releases sulfur into the air that dirties your property, imposing a cost on you.

Prion research doesn't necessarily impose costs on anyone.

Re: France issues moratorium on prion research after fatal brain disease strikes

#85
These mad scientists need to be stopped. How about all research into gain of function, genetic engineering viruses, prions, etc. need to have a moratorium. There is too much risk & not enough transparency on all levels.

We don't hear about all of the problems. I wonder what else is wrong and what happened. Whistleblowers need protection, not punishment.

Re: France issues moratorium on prion research after fatal brain disease strikes

#86

Earlier quoted context omitted.

It's not really effective because it takes years to manifest symptoms of prion disease. Terrorism usually has a message attached to it, and "you're gonna start dying in 10 years" is not conducive to messaging.

In this case I guess the message targets people in other cities than the doomed one. "This could happen to your city too".

you'd still have to wait a decade after the first attack to make threats on the second city.

Re: France issues moratorium on prion research after fatal brain disease strikes

#87
post #25

Earlier quoted context omitted.

That is an excellent way of thinking about them. For anyone unfamiliar, OP is referring to the Kurt Vonnegut novel which has a fictional state of water (ice-nine) that immediately freezes all other water it comes into contact with into more ice-nine. Edit: I committed a sin and didn't mention the title: Cat's Cradle.

There must be some kind of counter-agent, or life as we know it would not exist.

To prion diseases? Mainly in that they're not that common, more like a weird aberration than something that actively fights and adapts for its own survival like bacteria and viruses.

I mean cancer is not contagious, but it still kills millions a year.

Re: France issues moratorium on prion research after fatal brain disease strikes

#88

The study of rare, contagious diseases seems likely enough to result in an eventual outbreak that it should be treated like enriching uranium. Which is to say, with great caution- and not like regular science but rather like the kind of science with potentially very negative externalities.

Known prions can’t cause an outbreak without extraordinary methods of spread, such as cannibalism.

Re: France issues moratorium on prion research after fatal brain disease strikes

#89

Hm: "long period of uncertainty began on 31 May 2010, when she stabbed her left thumb with a curved forceps while cleaning a cryostat—a machine that can cut tissues at very low temperatures—that she used to slice brain sections from transgenic mice infected with a sheep-adapted form of BSE . She pierced two layers of latex gloves and drew blood" Later in the article: ""We conduct research only on mouse-adapted sheep…

Disclaimer: I know nothing about prions.

I think there's a mistake in the article, her website goes into more detail:

https://soutien-a-emilie0.webnode.fr/lhistoire/ (gtranslate)

> Emilie is therefore working that day on samples of mice infected with strains of human prions. It is important to stress here that these were human strains and not animal strains, the species barrier no longer protecting, the infectivity of the pathogens handled by Emilie was therefore total.

Re: France issues moratorium on prion research after fatal brain disease strikes

#90

Earlier quoted context omitted.

> Why does every lab have to be shut down for 3 months? Auditing everyone and their processes takes a while.

Why would you audit processes when the allegation is that someone got infected because she wasn't following the processes?

if we have some dangerous prion, and some person is bypassing procedure, that still is needing some evaluation. prion escape and becoming common in populations would be a large disaster.
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