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Temozolomide Is Explosive

blogs.sciencemag.org

31–40 of 128 posts

Re: Temozolomide Is Explosive

#31
post #17

Earlier quoted context omitted.

I think you're overlooking the most important scenario: mass production of it in a factory setting.

And just handling/storage. Things that are flammable or explosive have more-stringent requirements. A familiar example: one should take much greater care when storing rubbing alcohol (or Bacardi 151 or vodka) than wine. One will magnify a house-fire. The other will help to douse a flame.

At every people’s house, I see a cupboard with the chemicals. WD-40, 90° alcohol, acetone, white spirit, all in the same IKEA (=plywood) cupboard (although it would be hard to protect children if they were each in a different cupboard too). I wonder how many fires start from the chemicals cupboard. We know that a lot of artists had their rag pile spontaneously heating up then catching fire…

Re: Temozolomide Is Explosive

#33
post #25

Earlier quoted context omitted.

Nitrogen-Nitrogen bonds inside larger molecules are never quite stable because 1) nitrogen “wants” to form stable di-nitrogen (N2) molecules containing a very stable triple bond (an exothermic reaction) and 2) the result of such decompositions is nitrogen gas increasing the amount of entropy released (due to more molecules being created). Reactions are driven both by the amount of heat released (enthalpy) and the amo…

Does the same apply to oxygen? Since it also likes to be in a diatomic form.

The opposite, or oxygen wouldn't be such a strong oxidiser, which implies it readily and energetically leaves its double bond behind for either single bonds (H2O) or double bonds with non-oxygen atoms (CO2).

Re: Temozolomide Is Explosive

#35
Maybe helpful to note that the phrase "Class 1 Explosive" isn't denoting a certain type, or power of "Explosive". "Class 1" in Hazmat is all explosives. Class 2 is Gases. Class 3 is Flammable or Combustible liquid, and so on.

Re: Temozolomide Is Explosive

#36
post #24

I mean in fairness we still use nitroglycerine for some heart ailments, so chemo - a field filled with horrific chemicals - having an explosive shouldn't be too surprising.

The surprising part is that it’s been around since the 1970s and someone has only just gotten around to discovering this.

Re: Temozolomide Is Explosive

#37
post #7

"What they found was rapid onset of decomposition at 170 degrees" So this seems to be more about people in a lab situation rather than it being so unstable it reacting sitting in someone's hot car. Suspecting it to react at 212 and finding it reacting at 170 could ruin a lab tech's day to be sure. Those are the jobs that sound fun "for the science" lets see what happens when...

nb: Decomposition happens at 170 degrees Celsius - around 340 degrees Fahrenheit. A fair bit warmer than a hot car usually gets.

Re: Temozolomide Is Explosive

#38

Reminds me of how DNP, a chemical used for creating explosives, has been used as a weight-loss drug. It's surprisingly effective, but overdosing on it will result in a long, hot, agonizing death.

The fundamental reason why 2,4-Dinitrophenol (DNP) burns fat is surprisingly complicated. Basically, it intoxicates mitochondria in your cells being their power houses. These organelles create ATP, a universal metabolic energy carrier, by maintaining a proton gradient across its membrane. By means of chemical osmosis this gradient is what drives the ATP synthase enzyme under normal conditions. Now, DNP is capable of shuttling protons along the gradient and short-circuits this process catalyzing the conversion of fatty acids into worthless heat.

Interestingly, babies use a controlled variant of this mechanism to help maintain their body temperature thanks to their brown fat tissue. It makes babies look cute and keep warm. :)

Re: Temozolomide Is Explosive

#39
post #6

Chemotherapy is basically cave man medicine. That a therapeutic drug is explosive only adds to that sentiment. The idea that we'll basically poison you just up to a point that's nearly fatal in order to kill the cancer is such a terrible way to treat someone. Now I'm not saying don't ever do it -- unfortunately that's where we're at in 2021. It's just kind of unbelievable that cancer remains so elusive that we're sti…

A rather surprising number of chemo compounds trace directly to chemical warfare and compounds used during WWI, including several mustard-gas-related compounds.

Some years ago, a close friend died of a relatively rare and aggressive form of cancer. Among my roles was running interference against those who were pitching various miracle cures, with that tired old scam laetril playing a significant role.

In the decades since, I've watched developments in the science and development, as well as traced the history. It turns out that the treatment received a few decades ago was little changed from that of the 1960s, and has progressed little since. Genetic sequencing identified the affected chromosome of the triggering mutation in the 1980s, and we now know the specific codons involved. There remains no cure.

Five year survival remains about 20%. Laetril is still a fraud. And several of the other patients we came to know during the course of my friend's treatment have died since of conditions related to the treatment itself, though yes, they did buy another 10--20 years.

Cancer is brutal.

I will note: "cancer" is a symptom cluster manifested by malignant growth, and virtually always due to genetic mutation within the affected cells (I'd say "always" though I'm not completely sure of that). The specific triggers, and the possibilities for cure, vary tremendously. Some bladder cancers are virtually entirely treatable by, of all things, tuberculosis baccili. Skin cancers if caught early pose little risk. Others are tremendously aggressive, and an online friend's posts progressed from announcing their partner's diagnosis with liver cancer to the partner's death over the course of less than two months.

Broad-brush statements are virtually always false.

Re: Temozolomide Is Explosive

#40
post #6

Chemotherapy is basically cave man medicine. That a therapeutic drug is explosive only adds to that sentiment. The idea that we'll basically poison you just up to a point that's nearly fatal in order to kill the cancer is such a terrible way to treat someone. Now I'm not saying don't ever do it -- unfortunately that's where we're at in 2021. It's just kind of unbelievable that cancer remains so elusive that we're sti…

I am not surprised the a Class 1 HAZMAT is used as the chemo agent for glioblastoma, the most malignant form of brain tumor. My father in law just recently passed with glioblastoma stage 3, from admitted to hospital to passing in a couple of month.
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