11–20 of 33 posts
“Participants were then intentionally infected with malaria three months later to test the vaccine’s efficacy.” I did not know that purposely infecting people with a deadly parasite for research was a thing!
Do they screen enrollees based on scientific literacy? Seems like there could be significant moral hazards here.
Nice idea, but there's no way something like this would pass FDA. Even for the live VSV Ebola vaccine that contains no Ebola at all in it, except for the encoded spike, it's recommended for a doctor to do administration, and it's not commercially available, so you have to justify your need for it to the federal government. You are also supposed to avoid close contact with anyone else for quite a while after, to preve…
How do vaccines with live parasites work? Does attenuation somehow guarantee that the live parasites won't replicate to the point of becoming a full-on infection? Can these vaccines only be used on patients with healthy immune systems, and those with weakened immune systems have the potential for cascading replication and full infections?
So I guess they are monitoring the vaccinated closely. Honestly sounds a bit touchy.
How do vaccines with live parasites work? Does attenuation somehow guarantee that the live parasites won't replicate to the point of becoming a full-on infection? Can these vaccines only be used on patients with healthy immune systems, and those with weakened immune systems have the potential for cascading replication and full infections?
“Participants were then intentionally infected with malaria three months later to test the vaccine’s efficacy.” I did not know that purposely infecting people with a deadly parasite for research was a thing!
I wonder how disclosure works for the "field study testing the vaccine in adults is under way in Mali." Do they screen enrollees based on scientific literacy? Seems like there could be significant moral hazards here.
“Participants were then intentionally infected with malaria three months later to test the vaccine’s efficacy.” I did not know that purposely infecting people with a deadly parasite for research was a thing!
Parasite, not a virus. For some parts of the world, it's like getting the flu. You expect to get it every year.
How do vaccines with live parasites work? Does attenuation somehow guarantee that the live parasites won't replicate to the point of becoming a full-on infection? Can these vaccines only be used on patients with healthy immune systems, and those with weakened immune systems have the potential for cascading replication and full infections?
There are other vaccines such as the polio (the one which was swallowed) which had a similar mechanism. You could even infect others with it (which has benefits for herd immunity). But the chances of vaccine-associated paralytic poliomyelitis was extremely low 1:2.700.000 (it was not given to people with immunity defects).
Nice idea, but there's no way something like this would pass FDA. Even for the live VSV Ebola vaccine that contains no Ebola at all in it, except for the encoded spike, it's recommended for a doctor to do administration, and it's not commercially available, so you have to justify your need for it to the federal government. You are also supposed to avoid close contact with anyone else for quite a while after, to preve…
https://academictimes.com/first-vaccine-to-fully-immunize-ag...
[0] https://blogs.sciencemag.org/pipeline/archives/2021/04/23/gr... Previous HN Discussion: https://news.ycombinator.com/item?id=26916237